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Amebic Liver Abscess

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Single or multiple areas of PUS due to infection by any ameboid protozoa (AMEBIASIS). A common form is caused by the ingestion of ENTAMOEBA HISTOLYTICA.

Also Known As:

Liver Abscess, Amebic; Amoebiasis, Hepatic; Hepatic Abscess, Amoebic; Hepatic Amoebiasis; Liver Abscess, Amoebic; Abscess, Amebic Liver; Abscess, Amoebic Hepatic; Abscess, Amoebic Liver; Abscesses, Amebic Liver; Abscesses, Amoebic Hepatic; Abscesses, Amoebic Liver; Amebic Liver Abscesses; Amoebic Hepatic Abscess; Amoebic Hepatic Abscesses; Amoebic Liver Abscess; Amoebic Liver Abscesses; Entamoebiases, Hepatic; Hepatic Abscesses, Amoebic; Hepatic Entamoebiases; Liver Abscesses, Amebic; Liver Abscesses, Amoebic; Abscess, Amebic, Hepatic; Abscess, Hepatic, Amebic; Abscess, Liver, Amebic; Amebiasis, Hepatic; Entamoebiasis, Hepatic; Hepatic Amebiasis; Hepatic Entamoebiasis

Networked: 491 relevant articles (30 outcomes, 45 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Amebiasis (Amoebiasis)
2.	Amebic Dysentery (Amoebic Dysentery)
3.	Abscess
4.	Suppuration
5.	Infection

Experts

1.	Morán, Patricia: 6 articles (01/2014 - 12/2002)
2.	Shibayama, M: 6 articles (12/2011 - 07/2000)
3.	Lotter, Hannelore: 5 articles (10/2015 - 12/2004)
4.	Valadez, Alicia: 5 articles (01/2014 - 01/2009)
5.	Shibayama, Mineko: 5 articles (01/2014 - 03/2005)
6.	González, Enrique: 5 articles (01/2014 - 12/2002)
7.	Ximénez, Cecilia: 5 articles (01/2014 - 12/2002)
8.	Tannich, Egbert: 5 articles (01/2013 - 11/2003)
9.	Pacheco-Yépez, J: 5 articles (01/2011 - 07/2000)
10.	Tsutsumi, V: 5 articles (01/2011 - 07/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Amebic Liver Abscess:

1.	Metronidazole (Metric)FDA LinkGeneric 03/01/1985 - "Therefore, early diagnosis of amebic liver abscess in patients from endemic areas and treatment with metronidazole will result in successful therapy in 85% of cases. " 01/01/1980 - "[Delayed relapses of hepatic amoebiasis initially cured by metronidazole: 2 cases (author's transl)]." 01/01/2009 - "Randomised or quasi-randomised trials comparing an image-guided percutaneous procedure plus metronidazole versus metronidazole alone in patients with uncomplicated amoebic liver abscess. " 06/01/2005 - "This study shows that almost 50% of the patients with amebic liver abscess failed to respond to metronidazole and required aspiration." 11/01/2003 - "Treatment of amoebic liver abscess with metronidazole alone or in combination with ultrasound-guided needle aspiration: a comparative, prospective and randomized study."
2.	AntigensIBA 01/01/1980 - "The detection of amoebic antigen by counterimmunoelectrophoresis is very useful and important in the immunodiagnosis of invasive hepatic amoebiasis. " 01/01/2008 - "Oral vaccination with recombinant Yersinia conferred significant protection against amoebic liver abscess formation when the antigen was expressed as a fusion molecule with the translocation domain of Yersinia outer protein E. " 12/01/1990 - "histolytica antigen and may have contributed to the lack of development of effective in vivo cell-mediated immune responses following the onset of amebic liver abscesses." 09/01/1980 - "Protection against amebic liver abscess in hamsters by means of immunization with amebic antigen and some of its fractions." 12/01/2008 - "A study on the usefulness of Techlab Entamoeba histolytica II antigen detection ELISA in the diagnosis of amoebic liver abscess (ALA) at Hospital Universiti Sains Malaysia (HUSM), Kelantan, Malaysia."
3.	Proteins (Proteins, Gene)IBA 01/01/1990 - "The amoebic proteins most frequently recognised by sera from patients with cured amoebic liver abscess had molecular masses of 8, 13, 18, 22, 29, 38, 45, 67 and 94 kDa. Six plasma membrane-associated amoebic proteins of molecular mass 29, 38, 45-67 complex, 85 and 94 kDa were strongly recognised by such sera. " 09/01/1998 - "Parenteral and oral vaccine preparations containing recombinant amebic proteins have been effective in preventing disease in a gerbil model of amebic liver abscess. " 12/01/2004 - "Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess." 01/01/1992 - "Plasma concentrations of these two proteins are discussed in relation to their possible implications in the immunopathogenesis of amoebic liver abscess." 07/01/1991 - "One of these proteins is the first protective immunogen identified in the animal model of amebic liver abscess. "
4.	Galactose (Galactopyranose)FDA LinkGeneric 08/01/2000 - "histolytica galactose-binding adhesin is sufficient to confer substantial protection against experimentally induced amebic liver abscesses. " 12/01/2004 - "Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). " 12/01/2003 - "We followed 93 subjects with amebic liver abscess (ALA) and 963 close associate controls at 3-month intervals for 36 months to characterize intestinal and humoral antibody responses to the amebic galactose-inhibitable lectin and to determine whether immunity developed to Entamoeba histolytica or Entamoeba dispar infection following cure of ALA. " 07/01/2006 - "We monitored 93 subjects cured of amebic liver abscess (ALA) and 963 close associate controls in Durban, South Africa, and determined by enzyme-linked immunosorbent assay that the intestinal immunoglobulin A (IgA) antibody response to the Entamoeba histolytica galactose-inhibitable adherence lectin is most accurately represented by a complex pattern of transitory peaks. " 08/01/2000 - "Protection of gerbils from amebic liver abscess by vaccination with a 25-mer peptide derived from the cysteine-rich region of Entamoeba histolytica galactose-specific adherence lectin."
5.	Tinidazole FDA Link 05/01/1978 - "A study of tinidazole in hepatic amoebiasis." 01/01/1991 - "A short recovery by tinidazole is proposed as tentative treatment against hepatic amoebiasis in rural area's medicine." 01/01/1991 - "[Short treatment of hepatic amebiasis by tinidazole. " 06/01/1985 - "Low dose tinidazole in the treatment of amoebic liver abscess." 01/01/1978 - "Amoebic liver abscess and clinical experiences with tinidazole in Bangladesh."
6.	secnidazoleIBA 04/01/1996 - "Patients with hepatic amoebiasis appears to respond well to 5- to 7-day therapy with secnidazole, but the efficacy of this drug regimen requires further evaluation in larger numbers of patients. " 04/01/1998 - "Secnidazole is as effective in the treatment of amebic liver abscess as metronidazole; it is equally well tolerated." 04/01/1998 - "To compare the efficacy of secnidazole with metronidazole in the treatment of amebic liver abscess. " 04/01/1998 - "Randomized double-blind trial of metronidazole versus secnidazole in amebic liver abscess."
7.	Immune Sera (Antisera)IBA 12/01/1990 - "The suppressive activity of immune sera diminished as the time between therapy for amebic liver abscesses and serum collection increased (P less than 0.05). " 01/01/1990 - "Immune sera from 15 patients with cured amoebic liver abscess were used to recognise the antigens of Entamoeba histolytica (HMI) by immunoblotting. " 01/01/1988 - "Immune sera from 11 patients cured of amebic liver abscess was used to identify antigens of Entamoeba histolytica. " 01/01/2005 - "It is a major cell surface antigen which is universally recognized by the immune sera of patients with amoebic liver abscess (ALA). " 06/01/2004 - "Gal/GalNAc lectin is universally recognized by the immune sera of patients with amoebic liver abscess. "
8.	AntibodiesIBA 09/01/1996 - "Protection against amebic liver abscess formation in the severe combined immunodeficient mouse by human anti-amebic antibodies." 07/01/2000 - "Interaction of antibodies with Entamoeba histolytica trophozoites from experimental amebic liver abscess: an immunocytochemical study." 05/01/1994 - "Our study demonstrates that antibodies to a recombinant version of the amoebic SREHP molecule can protect against amoebic liver abscess, and suggest the recombinant SREHP molecule should be considered as a possible vaccine candidate to prevent amoebic liver abscess." 03/01/2013 - "We report two cases of amebic liver abscess illustrating the inequal sensitivity of serologic tests detecting anti-amebic antibodies." 08/01/2005 - "In addition, anti-Entamoeba histolytica antibodies from amoebic liver abscess patients recognized a richer antigenic Western blot pattern in the IC:MC fraction than in crude extract alone or with inhibitor. "
9.	EmetineIBA 06/01/1948 - "On the relative efficacy of emetine in intestinal and hepatic amebiasis." 04/01/1979 - "From 1974 to 1976 Acute Amoebic Hepatic Abscess treatment was viewed retrospectively with a random double blind prospective study administering metronidazol emetine, or a combination of both to three groups of 20 patients per group. " 03/01/1967 - "In two cases of amoebic liver abscess, which were treated by aspiration and emetine, there was a remarkable drop in the E.H. " 03/22/1963 - "[The place of emetine in the treatment of acute hepatic amebiasis]." 01/01/1963 - "[A case of autochthonous, emetine-resistant, recurrent and spontaneously regressive hepatic amebiasis]."
10.	DNA (Deoxyribonucleic Acid)IBA 12/10/1999 - "Our study indicates that DNA vaccination with SREHP can provide high levels of protection against amebic liver abscess in animal models of disease." 08/01/2010 - "histolytica DNA in saliva and urine could be used as a diagnostic tool for amebic liver abscess." 08/01/2010 - "histolytica DNA in 49%, 77%, and 69% of blood, urine, and saliva specimens from the amebic liver abscess patients. " 06/24/2009 - "We conclude that a refinement of this DNA vaccine could be a good choice to control hepatic amoebiasis." 12/01/2008 - "An attempt was made to detect Entamoeba histolytica DNA released in the saliva of amoebic liver abscess (ALA) patients by applying 16S-like rRNA gene-based nested multiplex polymerase chain reaction (NM-PCR). "

Therapies and Procedures

1.	Catheters 01/01/2012 - "It is concluded that percutaneous catheter drainage is more effective in management of large amoebic liver abscess than needle aspiration." 01/01/2012 - "This study was carried out to compare the efficacy, safety and outcome of needle aspiration comparing with percutaneous catheter drainage of large (> or = 5cm diameter) amoebic liver abscesses. " 04/01/1998 - "In a randomized study, 50 patients (38 males and 12 females; age range, 2-72 years; average age, 35 years) with liver abscesses (amebic, 20; pyogenic, 11; indeterminate, 19) underwent either percutaneous needle aspiration (n = 25) or catheter drainage (n = 25) along with appropriate antimicrobial therapy. " 09/01/2015 - "We report a case of a large amoebic liver abscess that presented with complications related to per-cutaneously inserted catheter drainage. " 09/01/2015 - "Per-cutaneously inserted catheter drainage is an accepted treatment modality for a large amoebic liver abscess. "
2.	Drug Therapy (Chemotherapy) 07/01/1989 - "Fifty patients with 56 amebic liver abscesses found to be resistant to drug therapy were included in the study. " 08/01/2000 - "We conclude that PCD is a most useful adjunct to drug therapy and recommend its routine use in the management of drug-resistant amoebic liver abscesses." 12/01/1990 - "Among them, development of a culture method applying diphasic medium, studies on virulence of the strains collected in Korea, and a combination of aspiration method and chemotherapy to treat amebic liver abscess are seen to have been contributing to the eventual goal of reducing this protozoa infection from the land." 08/01/2014 - "The majority of patients with amoebic liver abscesses were treated with drug therapy alone, whereas all pyogenic liver abscesses required some form of drainage." 11/25/1989 - "Chemotherapy with potent tissue amoebicidal drugs such as metronidazole is optimally effective in treating amoebic liver abscess, and in uncomplicated cases routine aspiration is not required."
3.	Intravenous Injections 12/01/1959 - "Induction of hepatic amoebiasis with two strains of Entamoeba histolytica has been attempted by direct inoculation of trophozoites into the livers of rats, hamsters, and guinea-pigs, and by intravenous injection into guinea-pigs. " 01/10/2004 - "[Amebic liver abscess with panperitonitis treated successfully with intravenous injection of metronidazole]."
4.	Intramuscular Injections 09/01/1980 - "Immunization of hamsters by intramuscular injections of an amebic extract and of two of its fractions, emulsified with complete Freund's adjuvant, resulted in protection against the development of amebic liver abscess, following intrahepatic inoculation of axenic trophozoites of Entamoeba histolytica such that Fraction I, Fraction II, and the whole antigen conferred protection to 18 out of 18, 4 out of 18, and 11 out of 18 hamsters, respectively. "
5.	Aftercare (After-Treatment) 03/01/2011 - "Relapse of intestinal and hepatic amebiasis after treatment." 12/01/2009 - "All were discharged well after treatment except for one case of death in a 69-year-old Chinese male with amebic liver abscess." 12/01/1987 - "Magnetic resonance images were obtained before and after treatment in 17 patients with 29 amebic liver abscesses. " 07/01/1992 - "We performed a prospective, controlled study of the T lymphocyte subpopulations in 17 patients with amoebic liver abscess before, and at 4 and 8 weeks after treatment with metronidazole (30 mg/kg/day). " 11/01/1999 - "The role of cytokines--tumour necrosis factor-alpha (TNF-alpha) and interleukin 2 (IL-2) in blood and pus aspirate was studied in 20 patients of amoebic liver abscess (ALA), before and after treatment and 10 controls. "