Lithocholic Acid

A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

Also Known As:

Networked: 316 relevant articles (7 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Min: 6 articles (03/2020 - 05/2014)
2.	Bi, Huichang: 5 articles (12/2019 - 05/2014)
3.	Chen, Pan: 4 articles (01/2017 - 05/2014)
4.	Fan, Xiaomei: 4 articles (01/2017 - 05/2014)
5.	Zeng, Hang: 4 articles (01/2017 - 05/2014)
6.	Fickert, Peter: 4 articles (07/2014 - 02/2006)
7.	Trauner, Michael: 4 articles (07/2014 - 02/2006)
8.	Kato, Norihisa: 4 articles (06/2013 - 09/2009)
9.	Okazaki, Yukako: 4 articles (06/2013 - 09/2009)
10.	Tomotake, Hiroyuki: 4 articles (06/2013 - 09/2009)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2010 - "In this study, a novel ST inhibitor AL10 derived from the lead compound lithocholic acid identified in our previous study is synthesized and the anti-cancer effect of this compound is studied. " 09/18/2014 - "The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. " 01/01/2008 - "Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. " 12/01/2003 - "The selective binding of lithocholic acid to AR supports the hypothesis that diet-related endoluminal substances may play a role in cancer development model where molecular alterations such as DNA damage or mutation is the 1st event." 04/11/2013 - "We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a template to design a new generation of improved EphA2 antagonists. "
2.	Cholestasis 05/01/2014 - "In this study, we characterized the protective effect of OA at low doses against lithocholic acid (LCA)-induced cholestasis in mice and explored further mechanisms. " 09/15/1994 - "In the present study, lithocholic acid (LCA) metabolism was assessed by radiochromatography and gas-liquid chromatography-mass spectrometry, and its relationship to cholestasis was investigated. " 06/01/1992 - "The aim of this study was to elucidate the mechanism of this potentiation using the lithocholate-induced cholestasis model. " 04/01/2023 - "Animal experiments in C57BL/6J and transgenic mice with IL32β/γ overexpression were also conducted to confirm the effect of IL-32 on necroptosis in cholestasis, which was induced by α-naphthylisothiocyanate (ANIT) and 1% lithocholic acid (LCA). " 01/01/2019 - "Cholestasis is a condition wherein bile flow is interrupted and lithocholic acid is known to play a key role in causing severe liver injury. "
3.	Inflammation (Inflammations) 06/01/2017 - "We identify a new role for the primary metabolite of UDCA, lithocholic acid, as a potent inhibitor of intestinal inflammatory responses, and we present data to suggest that microbial metabolism of UDCA is necessary for the full expression of its protective effects against colonic inflammation." 10/01/2021 - "We describe here the in silico design, synthesis, structural analysis and biological evaluation of two novel active lithocholic acid derivatives hydroxylated at the side chain as highly potent inhibitors of atopic dermatitis-relevant keratinocyte inflammation of potential therapeutic interest." 02/02/2018 - "Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis." 01/01/1979 - "Slight dose-related mean body weight depression was observed in male rats and female mice and high incidences of chronic kidney inflammation were observed in female rats, indicating that the dosages of lithocholic acid administered to these animals in this bioassay may have approximated the maximum tolerated dosages. " 12/01/2023 - "Notably, targeted metabolomic analysis identified elevated productions of fecal chenodeoxycholic acid and its microbial transformation product lithocholic acid, which might contribute to relieving canine intestinal inflammation. "
4.	Necrosis 10/30/2018 - "Histopathological investigations of the hepatic tissues showed that lithocholic acid exhibited severe hepatotoxicity, with areas of irregularly distributed necrosis with inflammatory infiltration. " 09/15/1994 - "Phase I and phase II metabolism of lithocholic acid in hepatic acinar zone 3 necrosis. " 02/01/1994 - "The mean glyco/tauro ratio was significantly higher than in the control group, reaching values > 1 for individual bile acids, except for lithocholic acid values which remained < 1. Under light microscopy, the livers of the hamsters showed damage which was dose/time related, namely portal inflammatory infiltrate, bile duct proliferation, cholestasis, fat infiltration and necrosis. " 04/01/1982 - "Light microscopy of the liver revealed fibrosis, inflammation, and bile duct proliferation in the portal regions in the three experimental groups; however, the lesions in the lithocholate and chenodeoxycholate groups were more severe and often associated with periportal extension of fibrosis and focal necrosis of the parenchyma. " 05/01/2013 - "We also showed that a TGR5 agonist and two types of BAs, deoxycholic acid and lithocholic acid, could inhibit tumour necrosis factor-α production in Mγ-Mϕs stimulated by commensal bacterial antigen or lipopolysaccharide. "
5.	Dermatitis 01/01/2022 - "Using an IL-23 minicircle DNA-based murine model of psoriasiform dermatitis, we showed that oral administration of secondary BAs, including lithocholic acid (LCA), deoxycholic acid, and 3-oxoLCA, significantly improved psoriasiform dermatitis without inducing apparent hepatotoxicity. "

Related Drugs and Biologics

1.	Bile Acids and Salts (Bile Acids)
2.	Deoxycholic Acid (Sodium Deoxycholate)
3.	Acids
4.	yangonin
5.	Tryptophan (L-Tryptophan)
6.	DNA (Deoxyribonucleic Acid)
7.	Salts
8.	Interleukin-23 (Interleukin 23)
9.	Interleukin-12 (IL 12)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Ligation
4.	Total Parenteral Nutrition
5.	Cholecystectomy