Lithium

06/01/2011 - "Bipolar Disorders are among the ten leading causes of morbity and lithium is considered first-line treatment and the most cost-effective. "
10/01/2008 - "Lithium has long been the first-line treatment for bipolar disorder, but it is not the most effective agent for treating bipolar depression. "
01/01/2008 - "Lithium, long considered a first-line treatment for bipolar disorder, is not the most effective agent for preventing bipolar depression. "
02/16/2006 - "The mood stabilizing drug lithium is a highly effective treatment for bipolar disorder. "
01/01/2005 - "Lithium is best described as the bench mark treatment for bipolar disorder, rather than the gold standard, because only a minority of patients show major clinical benefit. "

08/01/2015 - "Lithium is a widely used and highly effective treatment for mood disorders, but causes poorly characterised adverse effects in kidney and endocrine systems. "
07/01/2011 - "Lithium has been proved to be highly efficacious in the treatment of bipolar affective disorder, though a narrow therapeutic index and a high incidence of troublesome side effects often leads to poor compliance in patients. "
08/01/1999 - "Lithium remains the most widely used long-term treatment for bipolar affective disorder, but the molecular mechanisms underlying its therapeutic efficacy have not been fully elucidated. "
03/01/2004 - "Lithium has been found to be very effective in prophylactic treatment of affective disorders. "
08/23/2002 - "Various lithium (Li(+)) compounds have been proven to be effective in the therapy of bipolar affective disorder, but their mechanism of pharmacological action is not clearly defined. "

03/01/2002 - "Lithium also may be beneficial in recurrent unipolar depression and is an effective adjunct for treatment-resistant depression. "
11/01/1990 - "The results support the view that the everyday clinical use of lithium as prophylaxis is beneficial in unipolar depression."
08/01/1988 - "Lithium noncompliance is a significant barrier to effective treatment of manic-depressive disorders, yet the reasons for it are not well established. "
05/01/1985 - "A significant reduction was found on all indices during lithium management as compared to before lithium treatment, attesting to the efficacy of long-term prophylactic lithium in recurrent unipolar depression. "
06/01/1979 - "We concluded that ECT followed by either lithium or a tricyclic antidepressant is a more effective treatment for unipolar depression than ECT alone."

01/01/2015 - "There is no randomised trial-based evidence that lithium on its own is an effective treatment for people with schizophrenia. "
01/01/2007 - "There is no randomised trial-based evidence that lithium on its own is an effective treatment for people with schizophrenia. "
01/01/2003 - "There is no randomised trial based evidence that lithium on its own is an effective treatment for people with schizophrenia. "
01/01/1984 - "The present study investigated which symptoms of schizophrenia improved quickly during lithium treatment. "
05/01/1989 - "The authors review all double-blind studies assessing the efficacy of lithium treatment in schizophrenia. "

04/01/1987 - "Of the patients with schizoaffective disorder, manic type, 87.5% who received ECT showed "marked improvement"; almost 70% of patients who failed to respond to adequate lithium had "marked improvement" with ECT. "
03/01/1988 - "The study confirmed the efficacy of lithium prophylaxis in broadly defined schizoaffective disorders, but showed that this treatment is relatively ineffective in schizoaffective patients with a prominent schizophrenic-like component in their clinical picture and in those diagnosed cross-sectionally as schizodepressive. "
08/01/1989 - "The efficacy of lithium treatment in preventing relapse in phasal psychoses was tested by the re-examination of 99 patients at a Dresden clinic whose treatment had on average exceeded ten years. "
05/01/1984 - "Lithium-associated remission of psychosis has been described in schizophreniform disorders and in psychotic patients with variants of the red blood cell (RBC)/lithium ratio. "
11/01/2003 - "The major objective of this study was to examine if abnormalities of 5HT2A receptors are associated with bipolar or schizoaffective disorders and if treatment with lithium would cause changes in the 5HT2A receptors. "