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Lipoxygenase (Lipoxygenase-1)

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An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.

Also Known As:

Lipoxygenase-1; Linoleate-Oxygen Oxidoreductase; Lipoxygenase-2; Linoleate Oxygen Oxidoreductase; Lipoxygenase 1; Lipoxygenase 2; Oxidoreductase, Linoleate-Oxygen; Lipoxidase; Linoleate:oxygen 13-oxidoreductase

Networked: 1093 relevant articles (29 outcomes, 82 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kuhn, Hartmut: 7 articles (10/2015 - 02/2003)
2.	Yoshimura, Rikio: 7 articles (07/2008 - 11/2003)
3.	Matsuyama, Masahide: 7 articles (07/2008 - 11/2003)
4.	Sano, Hajime: 7 articles (07/2008 - 11/2003)
5.	Nakatani, Tatsuya: 7 articles (07/2008 - 11/2003)
6.	Kawahito, Yutaka: 7 articles (07/2008 - 11/2003)
7.	Tsuchida, Kenji: 6 articles (07/2005 - 11/2003)
8.	Rao, Chinthalapally V: 5 articles (07/2014 - 01/2007)
9.	Hadjipavlou-Litina, Dimitra: 4 articles (01/2015 - 07/2006)
10.	Holman, Theodore R: 4 articles (01/2014 - 06/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2013 - "Previous studies have demonstrated that the lipoxygenase is considered as a potential therapeutic target and have important influence on human cancers. " 01/01/2012 - "In previous studies, extracts of Morus alba demonstrated favorable biological properties, such as antioxidant activity, suppression of lipoxygenase (LOX)-1, cytotoxicity against cancer cells, and inhibition of the invasion and migration of cancer cells. " 06/01/2005 - "In the present study, we investigated whether the lipoxygenase pathway in resident murine peritoneal macrophages is affected by contact with tumor cells of a different origin, e.g. " 02/21/2005 - "The goal of this study was to determine whether CLA altered mouse mammary tumor cell growth and whether specific metabolites of the lipoxygenase pathway were involved in CLA action. " 05/01/2004 - "Recent studies have demonstrated that lipoxygenase (LOX) inhibitor induces growth arrest of cancer cells through apoptosis. "
2.	Ischemia 10/01/1991 - "This study was designed to determine the effect of thromboxane and lipoxygenase derivatives on the local and systemic response to ischemia and reperfusion of skeletal muscle. " 04/01/1990 - "This study tests the role of ischemia-induced lipoxygenase activity in mediating PMN activation and diapedesis. " 01/01/2013 - "This drug inhibits both nonenzymatic lipid peroxidation and the lipoxygenase pathway, in addition to having potent antioxidant effects against ischemia reperfusion. " 08/01/1996 - "The synthesis of the lipoxygenase product 12-hydroxyeicosatetraenoic acid (12-HETE) was not altered by hypothermic ischemia or reperfusion, but this arachidonate metabolite was produced by small intestinal mucosa in the greatest quantities. " 12/01/1994 - "These findings suggest that the site of action of MCl-186 as an anti-ischemic agent may be closely associated with the cerebral AA cascade, especially the lipoxygenase system, activated by ischemia-reperfusion."
3.	Inflammation 04/01/1991 - "Other studies have indicated a role for macrophage-derived lipoxygenase products in production of experimental pulmonary granulomatous inflammation. " 08/25/2010 - "Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation." 11/15/2009 - "Comment on "Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation"." 06/01/2009 - "However, the role of lipoxygenase (LO) metabolites in the development of Th1 inflammation is poorly understood. " 05/01/2009 - "Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation."
4.	Atherosclerosis 01/01/2010 - "Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study." 06/01/2006 - "Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis." 07/01/2004 - "Lipoxygenase pathways in atherogenesis." 02/04/2003 - "Here, we studied both lipoxygenase pathways in human atherosclerosis. " 01/01/2002 - "Because the lipoxygenase (LO) pathway has been associated with oxidant stress and the pathogenesis of atherosclerosis, we now examined 12-LO activation in vivo in a pig model of diabetes-induced accelerated atherosclerosis which displays human characteristics. "
5.	Asthma (Bronchial Asthma) 01/01/2015 - "Till now, asthma consists of the only pathological case in which improvement has been shown by lipoxygenase LO inhibitors. " 03/01/1995 - "Plasma from bronchial asthma patients and healthy controls was investigated for the content of lipoxygenase products. " 11/01/1994 - "Five-lipoxygenase (5-LOX) inhibition is gaining increasing importance as a novel approach to therapy of allergic asthma and other inflammatory diseases. " 01/01/1989 - "If this hypothesis can be substantiated in patients with bronchial asthma then pharmacologic modification of the lipoxygenase pathway and/or products may be important in the treatment of asthma." 01/01/1988 - "If the same mechanisms that are active in sheep are proven active in humans, then pharmacologic modification of the lipoxygenase pathway or its products (or both) may be important for the treatment of some forms of asthma."

Related Drugs and Biologics

1.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2.	Nordihydroguaiaretic Acid (Masoprocol)
3.	4,5- Dihydro- 1- (3- (trifluoromethyl)phenyl)- 1H- pyrazol- 3- amine
4.	Cyclooxygenase Inhibitors
5.	Arachidonic Acid (Vitamin F)
6.	phenidone
7.	Lipoxygenase Inhibitors
8.	Thromboxane-A Synthase
9.	Indomethacin (Indometacin)
10.	Leukotriene C4

Related Therapies and Procedures

1.	Surgical Instruments (Clip)
2.	Pancreas Transplantation
3.	Drug Therapy (Chemotherapy)
4.	Chemoprevention
5.	Ligation