beta-Lipotropin (Lipotropin)

A 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.

Also Known As:

Networked: 192 relevant articles (3 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matejec, Reginald: 6 articles (09/2013 - 01/2005)
2.	Bödeker, Rolf-Hasso: 4 articles (09/2013 - 02/2006)
3.	Hempelmann, Gunter: 4 articles (06/2009 - 01/2005)
4.	Mühling, Jörg: 3 articles (06/2009 - 01/2005)
5.	Teschemacher, Hansjörg: 3 articles (02/2006 - 01/2005)
6.	Kayser, Friederike: 2 articles (09/2013 - 01/2011)
7.	Löcke, Gudrun: 2 articles (01/2011 - 06/2009)
8.	Bödeker, Rolf-H: 2 articles (02/2006 - 01/2005)
9.	Uhlich, Holger: 2 articles (02/2006 - 01/2005)
10.	Harbach, Heinz-W: 2 articles (02/2006 - 01/2005)

Related Diseases

1.	Pain (Aches) 01/01/2005 - "Neither beta-END nor beta-LPH IRM nor beta-END(1-31) levels correlated with heat or pressure pain tolerance thresholds. " 01/01/1990 - "of 12 visits or 4 being made at the health care centre; despite the intensity of the dynamic training-program employed with RA patients, no increase in pain experience or disease activity was found during the training-period; during short-term high-intensity training a significant increase in circulating beta-EP was found between the 3rd and 6th weeks of training, no increase in CRF and beta-LPH being present; following a long-term low-intensity training period, a significant increase of CRF and beta-LPH was found, no similar increase being noted for beta-EP." 01/01/2005 - "We conclude that CRH does not modulate heat, but pressure pain; POMC derivatives like beta-END IRM, beta-END(1-31) or beta-LPH do not mediate this effect." 01/01/1988 - "A 50% increase of cerebrospinal beta-endorphin and beta-lipotropin levels occurred in 6 out of 16 patients, namely those where SCS gave the major pain relief. " 05/01/1985 - "Endorphins and beta-lipotropin have been implicated as the modulators of pain during the labor process. "
2.	Neoplasms (Cancer) 10/25/1979 - "Characterization of mouse tumor cell beta-lipotropin." 04/01/1979 - "Ectopic production of lipotropin by cancer." 07/01/1978 - "Except in the plasma and tumors of occasional patients with ectopic ACTH syndrome, the smallest IR-LPH appears to be lambda-lipotropin (lambdaLPH), which is often the predominant and occasionally the only IR-LPH present. " 04/01/1988 - "Initial plasma disappearance t1/2 values of IR-ACTH and lipotropin were 22-27 min. In summary, responses in normal and Cushing's dogs were generally what would be predicted from previous human and animal studies, but some of those in animals with pars intermedia tumors and even in normal dogs were different from what had been anticipated. " 07/01/1985 - "In 3 patients with adrenal tumors, beta LPH concentrations were low, and cortisol concentrations did not decline during the Dex infusion. "
3.	Neoplasm Metastasis (Metastasis) 05/01/1980 - "Four months later lymph node and mediastinal metastases of an anaplastic small cell carcinoma, with the presence of argyrophil granulation, as well as immunoreactive 19-39ACTH, beta-LPH and alpha-endorphin, were found. " 08/01/1986 - "The primary tumour and its metastases showed immunocytochemical staining for ACTH, beta-lipotrophin, and variably for beta-endorphin and alpha-melanocyte stimulating hormone (alpha-MSH). " 08/01/1981 - "The effects of neuroadenolysis on plasma titres of beta-endorphin, beta-lipotropin, ACTH, TSH and prolactin have been investigated in five patients with metastatic cancer who responded to the treatment and have been in remission for more than four years and in five others who were undergoing the treatment for the first time for pain due to cancer metastases. "
4.	Renal Insufficiency (Renal Failure) 08/01/1990 - "The data indicate that the carbohydrate intolerance in experimental renal failure may be partly due to an increase in pancreatic islet opioidergic tone, because an improvement in insulin secretion was demonstrated in the absence of any change in circulating beta-endorphin/beta-lipotropin concentrations after naloxone. " 08/01/1990 - "Plasma concentrations of glucose, insulin, and beta-endorphin/beta-lipotropin were measured in male Sprague-Dawley rats with experimental renal failure after intravenous glucose challenge in the presence and absence of opioid blockade with intravenously administered naloxone. "
5.	Uremia 10/01/1981 - "Impaired clearance of beta-lipotropin in uremia."

Related Drugs and Biologics

1.	beta-Endorphin (Endorphin, beta)
2.	Adrenocorticotropic Hormone (ACTH)
3.	Insulin (Novolin)
4.	Prolactin
5.	Naloxone (Narcan)
6.	beta-Lipotropin (Lipotropin)
7.	Corticotropin-Releasing Hormone
8.	Hydrocortisone (Cortisol)
9.	Pro-Opiomelanocortin (Proopiomelanocortin)
10.	alpha-MSH

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Cesarean Section (Caesarean Section)
3.	Aftercare (After-Treatment)
4.	Arthroplasty
5.	Spinal Anesthesia