HDL Lipoproteins

A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.

Also Known As:

Networked: 1104 relevant articles (37 outcomes, 89 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gursky, Olga: 13 articles (06/2014 - 08/2005)
2.	Rye, Kerry-Anne: 12 articles (03/2015 - 11/2005)
3.	Barter, Philip J: 11 articles (03/2015 - 11/2005)
4.	Jayaraman, Shobini: 10 articles (06/2014 - 08/2005)
5.	Rader, Daniel J: 7 articles (12/2012 - 01/2002)
6.	Ozerova, I N: 7 articles (03/2007 - 10/2000)
7.	Perova, N V: 7 articles (03/2007 - 10/2000)
8.	Calabresi, Laura: 7 articles (12/2006 - 02/2003)
9.	Franceschini, Guido: 7 articles (12/2006 - 02/2003)
10.	Nicholls, Stephen J: 6 articles (07/2009 - 11/2005)

Related Diseases

1.	Atherosclerosis 07/01/2008 - "Administration of synthetic high-density lipoproteins has proven to be effective in promoting atherosclerosis regression not only in animal models, but also in humans. " 06/01/1988 - "In spite of having very high levels of high-density-lipoproteins, which are known to be protective against atherosclerosis, this animal develops a severe atheromatous disease especially in the abdominal aorta, where the cellular growth has also been proven to be in vitro more pronounced than in the thoracic tract. " 01/01/2015 - "High-density lipoproteins (HDLs) exert many beneficial effects which may help to protect against the development or progression of atherosclerosis or even facilitate lesion regression. " 10/15/1998 - "Epidemiological, clinical, and experimental studies have demonstrated that high density lipoproteins (HDL) are protective against atherosclerosis. " 05/01/2014 - "Athero-protective effects of High Density Lipoproteins (HDL): An ODE model of the early stages of atherosclerosis."
2.	Cardiovascular Diseases (Cardiovascular Disease) 12/01/2014 - "This article reconciles the classic view of high-density lipoproteins (HDL) associated with low risk for cardiovascular disease (CVD) with recent data (genetics studies and randomized clinical trials) casting doubt over the widely accepted beneficial role of HDL regarding CVD risk. " 02/01/2003 - "In addition, most studies also indicate that significant declines in high-density lipoproteins occur leading to an increased cardiovascular disease risk. " 07/01/2014 - "High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm." 12/01/2013 - "High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease." 09/01/2013 - "High-density lipoproteins (HDL) are known to protect against cardiovascular disease (CVD). "
3.	Coronary Disease (Coronary Heart Disease) 10/01/2009 - "Impaired protection against diabetes and coronary heart disease by high-density lipoproteins in Turks." 12/01/1990 - "Data from epidemiological studies have consistently shown that elevated levels of high density lipoproteins (HDL) are an index of increased protection against coronary heart disease. " 08/01/2009 - "Although controversial, a few studies have suggested a protective role for Se in coronary heart disease on the basis of modulation of high-density lipoproteins (HDL). " 01/01/1978 - "The accurate quantitation of high density lipoproteins has recently assumed greater importance in view of studies suggesting their negative correlation with coronary heart disease. " 04/01/2015 - "Accordingly, lower HDL seems to contribute more to the development of coronary heart disease (CHD) than an increase in non-HDL lipoproteins at a population level in Japan. "
4.	Body Weight (Weight, Body) 01/01/2013 - "ZTO also showed similar effects to those of ZPTO with additional merits being more effective in reducing AI, body weight and more importantly raising high-density lipoproteins. " 01/01/2014 - "Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice." 01/01/2007 - "This decrease was also accompanied by an increase in high density lipoproteins (HDL) by 9% and an increased HDL-C/TC ratio of 52% at the dose of 250 mg/kg of body weight." 04/01/1998 - "In vitro oxidizability of non-HDL lipoproteins is significantly increased in obese, non-diabetic subjects and related to increased body weight and triglyceride levels. " 01/01/1984 - "Changes in plasma high-density lipoproteins after body weight reduction in obese women."
5.	Hypertriglyceridemia 01/01/2014 - "The patient also developed hepatic nonalcoholic steatosis, mild hypertriglyceridemia, and reduced levels of high-density lipoproteins. " 11/01/2012 - "Such disorders of lipid metabolism as hypertriglyceridemia and decrease of concentration of high density lipoproteins are established. " 07/01/1990 - "from a great decrease at initially high LDLC levels to a small increase at initially low LDLC in patients with hypertriglyceridemia and low levels of high density lipoproteins. " 07/01/1987 - "Characterization of high density lipoproteins from patients with severe hypertriglyceridemia." 02/01/1985 - "On the other hand, high density lipoproteins (HDL) are decreased, so that we can ask the question: Is HDL decrease due to diabetes or as a result of hypertriglyceridemia?"

Related Drugs and Biologics

1.	Cholesterol
2.	LDL Lipoproteins (beta Lipoproteins)
3.	Lipoproteins (Lipoprotein)
4.	HDL Cholesterol
5.	Lipids
6.	Glucose (Dextrose)
7.	LDL Cholesterol
8.	Fibric Acids (Fibrates)
9.	Triglycerides (Triacylglycerol)
10.	Apolipoprotein A-I (Apolipoprotein A1)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Drug Therapy (Chemotherapy)
3.	Transplants (Transplant)
4.	Transplantation (Transplant Recipients)
5.	Ketogenic Diet