Lipoprotein Lipase (Diacylglycerol Lipase)

An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.

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Networked: 1645 relevant articles (48 outcomes, 190 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shirai, Kohji: 14 articles (01/2014 - 01/2002)
2.	Goldberg, Ira J: 13 articles (05/2015 - 06/2002)
3.	Olivecrona, Gunilla: 10 articles (07/2013 - 02/2003)
4.	Tsutsumi, Kazuhiko: 9 articles (10/2011 - 01/2002)
5.	Kastelein, John J P: 9 articles (12/2008 - 07/2002)
6.	Eckel, Robert H: 8 articles (08/2014 - 08/2004)
7.	Havekes, Louis M: 8 articles (12/2009 - 08/2003)
8.	Hayden, Michael R: 8 articles (08/2009 - 09/2004)
9.	Rodrigues, Brian: 7 articles (01/2016 - 02/2006)
10.	Gaudet, Daniel: 7 articles (01/2015 - 06/2002)

Related Diseases

1.	Hypertriglyceridemia 01/01/2007 - "Differential diagnosis of hypertriglyceridemia and medical practice involved in their prevention and treatment may be improved by knowing the frequency of lipoprotein lipase gene variants as well as their influence on lipid profile." 01/01/2006 - "We conclude that RTV causes hypertriglyceridemia via decreased lipoprotein lipase-mediated clearance of VLDL-TG. " 01/01/1992 - "Patients with diabetes commonly manifest hypertriglyceridemia along with decreased adipose tissue lipoprotein lipase (LPL) activity, and improved diabetes control tends to reverse these abnormalities. " 01/01/1993 - "Previous studies have demonstrated that endotoxin/lipopolysaccharide treatment causes a decrease in adipose tissue and heart lipoprotein lipase (LPL) activities in rats, producing hypertriglyceridemia in these animals. " 02/01/1988 - "Six patients with severe hypertriglyceridemia (2 type IV and 4 type V) and low lipoprotein lipase (LPL) activity took part in a second, open study, lasting for 9 months. "
2.	Obesity 06/01/2010 - "The aim of this study was to examine regional variation in adipose tissue lipoprotein lipase (AT-LPL) activity and expression in pre-and postmenopausal women, before and after training, once differences in chronological age or obesity degree are taken into account. " 06/01/2009 - "In fact, studies with genetically engineered mice have revealed that the activity of lipoprotein lipase (LPL) is a major determinant for the development of obesity. " 08/01/2006 - "Influence of lipoprotein lipase gene Ser447Stop and beta1-adrenergic receptor gene Arg389Gly polymorphisms and their interaction on obesity from childhood to adulthood: the Bogalusa Heart Study." 05/01/2003 - "Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study." 09/01/1978 - "Few systematic studies of triglyceride removal or postheparin lipoprotein lipase activity (LPLA) in obesity have appeared. "
3.	Hyperlipidemias (Hyperlipidemia) 07/01/2001 - "The purpose of the present study was to examine the influence of moderate intensity exercise on postprandial lipemia and muscle lipoprotein lipase (LPL) activity. " 10/01/2014 - "We present a 4.8-year-old female with grade 3 lipemia retinalis due to lipoprotein lipase deficiency, an abnormal electroretinogram, and bilateral decreased visual acuity. " 02/15/2014 - "Familial chylomicronemia (type I hyperlipidemia) is a rare autosomal recessive disease due mainly to rare variants in the lipoprotein lipase (LPL) gene sequence. " 01/01/2012 - "Physical activity and postprandial lipidemia: are energy expenditure and lipoprotein lipase activity the real modulators of the positive effect?" 11/01/2010 - "Hyperlipidemia resulting in abnormal density and signal intensity of blood in a neonate with lipoprotein lipase deficiency."
4.	Coronary Artery Disease (Coronary Atherosclerosis) 04/01/2001 - "Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile." 01/01/2007 - "Our aim was to determine whether lipoprotein lipase gene PvuII polymorphism can be considered as an independent risk factor for coronary artery disease (CAD) by conducting a meta-analysis of all available published trials, including our own study. " 03/01/2006 - "Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study." 07/01/2003 - "To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease. " 05/01/2003 - "Previous studies reported an association of certain polymorphisms in the lipoprotein lipase (LPL) gene with the risk of coronary artery disease (CAD); however, these studies were small and inconsistent. "
5.	Pancreatitis 01/01/2014 - "The data from this study showed that compound heterozygote mutations of A98T and L279V inactivate lipoprotein lipase enzymatic activity and contribute to severe HTG and acute pancreatitis in two Chinese patients. " 08/01/2012 - "Lipoprotein lipase deficiency is a rare inherited disease characterized by severe hypertriglyceridaemia, chylomicronaemia and risk of recurrent pancreatitis or other complications. " 10/04/2010 - "In the case of lipoprotein-lipase mutations, lipid levels may rise to extreme levels during acute pancreatitis. " 02/01/2009 - "Acute hypertriglyceridemic pancreatitis during pregnancy due to homozygous lipoprotein lipase gene mutation." 01/01/2009 - "Recurrent pancreatitis is a common complication of severe hypertriglyceridaemia (HTG) often seen in patients carrying various gene mutations in lipoprotein lipase (LPL). "

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Lipase (Acid Lipase)
3.	Triglycerides (Triacylglycerol)
4.	LDL Receptors (LDL Receptor)
5.	Chylomicrons
6.	Cholesterol
7.	Messenger RNA (mRNA)
8.	Apolipoproteins
9.	Heparin (Liquaemin)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)
2.	Transplants (Transplant)
3.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4.	Thyroidectomy
5.	Renal Dialysis (Hemodialysis)