Lipopolysaccharides

Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)

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Networked: 957 relevant articles (19 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	David, Sunil A: 13 articles (01/2013 - 05/2004)
2.	Wood, Stewart J: 8 articles (02/2006 - 05/2004)
3.	Miller, Kelly A: 7 articles (09/2007 - 05/2004)
4.	Burns, Mark R: 5 articles (02/2007 - 04/2005)
5.	Brandtzaeg, Petter: 4 articles (03/2014 - 06/2002)
6.	Delzenne, Nathalie M: 4 articles (01/2013 - 04/2002)
7.	Yang, Yi: 4 articles (11/2006 - 02/2002)
8.	Ren, Chunhua: 3 articles (11/2015 - 12/2014)
9.	Chen, Ting: 3 articles (11/2015 - 12/2014)
10.	Jiang, Xiao: 3 articles (11/2015 - 12/2014)

Related Diseases

1.	Inflammation 01/01/2015 - "Many studies have shown that lipopolysaccharides cause functional and structural changes in the inner ear similar to that of inflammation. " 07/01/2014 - "In this study, we hypothesize that this stem cell niche is also affected during inflammation and therefore investigated lipopolysaccharides (LPS) effects on enteric neural stem/progenitor cells (NSPCs). " 01/01/2014 - "In this study, we investigated the role of LXRs agonist TO901317 (TO) on lipopolysaccharides (LPS)-induced myocardial inflammation and autophagy. " 07/01/2013 - "In the present study, we examined the anti-inflammatory effects of C. obtusa essential oil in vivo and in vitro following the induction of inflammation by lipopolysaccharides (LPS) in rats. " 11/01/2008 - "The present study aimed to investigate the effects of endotoxin-induced inflammation (LPS, lipopolysaccharides) on the behavior of healthy conspecifics to verify a possible active social isolation of the immune-challenged animal. "
2.	Infection 12/01/2015 - "In the present study, we found that miR-137 expression was slightly attenuated and miR-2008 was significantly enhanced after Vibrio splendidus infection or Lipopolysaccharides application. " 09/29/2015 - "Functional studies in mice demonstrated that Batf2 has a central role in macrophage activation by regulating inflammatory responses during lipopolysaccharides stimulation and mycobacterial infection. " 08/02/2002 - "This study examined whether an infection with porcine reproductive and respiratory syndrome virus (PRRSV) potentiates respiratory signs upon exposure to bacterial lipopolysaccharides (LPS). " 06/15/2015 - "Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection." 01/01/2015 - "Taking this assumption into account, we experimentally induced sickness behavior in rats using lipopolysaccharides (LPS), an endotoxin that mimics infection by gram-negative bacteria, and then exposed these rats to a restraint stress challenge. "
3.	Sepsis (Septicemia) 04/01/1985 - "Protection against fatal Pseudomonas aeruginosa sepsis by immunization with smooth and rough lipopolysaccharides." 05/01/1996 - "Lipopolysaccharides (LPS), widely used to study the mechanisms of gram-negative sepsis, increase airway resistance by constriction of terminal bronchioles. " 01/01/2015 - "Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice. " 08/01/2014 - "We investigated the role of IL-32γ in a mouse model of experimental sepsis by using lipopolysaccharides (LPS). " 05/01/2014 - "Lf can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages. "
4.	Shock 04/01/1987 - "The biphasic behaviour observed in endotoxin-induced shock attributed to a direct interaction of bacterial lipopolysaccharides with the cell membrane and an indirect activation of multiple homeostatic regulatory mechanisms, cannot be completely elucidated with in vivo studies. " 05/07/1996 - "Lipopolysaccharides from Gram-negative bacteria interact with the mammalian immune system to trigger a cascade of physiological events leading to a shock syndrome which results in the death in over 70% of cases of severe shock. " 07/01/1978 - "In endotoxin shock, a primary mixed coagulopathy develops as an event directly related to the presence of bacterial lipopolysaccharides. " 01/01/1978 - "Contamination by bacterial lipopolysaccharides, however, resulted in endotoxin shock in 32 out of 35 vaccinees with one vaccine lot. " 01/01/2011 - "Endotoxin shock was induced by intravenous injection of Klebsiella pneumoniae lipopolysaccharides (LPSs; 10 mg/kg) in conscious rats. "
5.	Uveitis 01/01/2008 - "The uveitis is severer if the lipopolysaccharides are injected intraocularly. " 04/01/2001 - "Escherichia coli lipopolysaccharides were injected to induce uveitis. " 01/01/2015 - "Endotoxin-induced uveitis (EIU) in rats was induced by a subcutaneous injection of lipopolysaccharides (LPS, 200 μg) in 0.1 ml of sterile saline. " 03/01/2015 - "Endotoxin induced uveitis is another useful model for anterior uveitis, which is not an autoimmune process and is triggered by injection of bacterial endotoxin (lipopolysaccharides) resulting in a rapid short lasting uveitis. " 01/01/2011 - "This study investigates the protective effects and mechanisms of lutein on lipopolysaccharides (LPS)-induced uveitis in mice. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Antibodies
4.	Immunoglobulin G (IgG)
5.	Rifampin (Rifampicin)
6.	Lutein
7.	BCG lipopolysaccharide
8.	Nitric Oxide (Nitrogen Monoxide)
9.	Monoclonal Antibodies
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Transplantation (Transplant Recipients)
3.	Intravitreal Injections
4.	Intraperitoneal Injections
5.	Injections