Lipidoses

Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.

Also Known As:

Networked: 479 relevant articles (13 outcomes, 45 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Ketosis
2.	Mucopolysaccharidoses
3.	Atherosclerosis
4.	Weight Loss (Weight Reduction)
5.	Lysosomal Storage Diseases (Lysosomal Storage Disease)

Experts

1.	Ioannou, Yiannis A: 4 articles (03/2009 - 02/2003)
2.	Ding, Xinxin: 3 articles (01/2013 - 01/2005)
3.	Oikawa, Shin: 3 articles (10/2010 - 01/2002)
4.	Nieminen, Petteri: 3 articles (09/2010 - 03/2009)
5.	Mustonen, Anne-Mari: 3 articles (09/2010 - 03/2009)
6.	Rouvinen-Watt, Kirsti: 3 articles (09/2010 - 03/2009)
7.	Saito, Takao: 2 articles (02/2014 - 02/2006)
8.	Matsunaga, Akira: 2 articles (02/2014 - 02/2006)
9.	Porter, Todd D: 2 articles (01/2013 - 06/2011)
10.	Gu, Jun: 2 articles (01/2013 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lipidoses:

1.	Carnitine (L-Carnitine)FDA LinkGeneric 09/01/1990 - "These data suggest that carnitine deficiency does not contribute to the pathogenesis of feline idiopathic hepatic lipidosis." 09/01/1990 - "The mean for the ratio of free/total carnitine in plasma and liver was lower (P less than 0.05) in cats with idiopathic hepatic lipidosis than in control cats. " 09/01/1990 - "The mean concentrations of plasma, liver, and skeletal muscle total carnitine; plasma and skeletal muscle free carnitine; and plasma and liver esterified carnitine were greater (P less than 0.05) in cats with idiopathic hepatic lipidosis than in control cats. " 09/01/1990 - "Concentrations of total, free, and esterified carnitine were determined in plasma, liver, and skeletal muscle from cats with idiopathic hepatic lipidosis and compared with values from healthy cats. " 09/01/1990 - "Comparison of plasma, liver, and skeletal muscle carnitine concentrations in cats with idiopathic hepatic lipidosis and in healthy cats."
2.	Fatty Acids (Saturated Fatty Acids)IBA 01/01/2009 - "The content of all these fatty acids increased significantly in the diabetic retina, reflecting lipidosis. " 01/01/2004 - "Results indicate that hepatic lipidosis markedly alters the proportions of the various fatty acids in the liver of dairy cows." 01/01/1987 - "Heart organelles appear to incorporate uncommon fatty acids like 22:1 and trans- 18:1. Diets enriched with 22:1 induce myocardial lipidosis. " 05/16/1983 - "8. These findings are discussed in relation to the transient nature of the cardiac lipidosis observed with animals fed on diets rich in C22:1 fatty acids. " 02/01/1982 - "Upon continued feeding of diets with 22:1 fatty acids, an adaptation takes place and the lipidosis disappears. "
3.	CholesterolIBA 01/01/2013 - "9-fold and 35-fold enrichment in cholesterol, consistent with alveolar lipidosis. " 09/01/2005 - "However, recent data indicate that cholesterol is not the primary culprit in this human lipidosis. " 06/01/2004 - "A low-fat and energy-restricted diet did not reduce either total cholesterol or the corneal lipidosis. " 08/21/2001 - "Niemann-Pick type C (NPC) disease is a cholesterol lipidosis caused by mutations in NPC1 and NPC2 gene loci. " 09/01/1999 - "Niemann-Pick type C (NPC) disease is a severe cell lipidosis characterized by the accumulation of unesterified cholesterol in the endosomal/lysosomal system. "
4.	erucic acidIBA 01/01/1978 - "Preliminary studies at our institute indicate lipidosis in the heart both in rats fed RSO and HMO, containing equivalent amounts of erucic acid and erucic acid isomers respectively. " 06/15/2014 - "Foodstuff with a high content of erucic acid is considered undesirable for human consumption because it has been linked to myocardial lipidosis and heart lesions in laboratory rats. " 08/01/1992 - "Effects of dietary saturated fat on erucic acid induced myocardial lipidosis in rats." 07/01/1983 - "The acute lipidosis was reversible with either continued feeding of erucic acid for several weeks or conversion to a normal diet. " 07/01/1983 - "Induction of a reversible cardiac lipidosis by a dietary long-chain fatty acid (erucic acid). "
5.	EnzymesIBA 01/01/2013 - "Lipid storage diseases, also known as the lipidoses, are a group of inherited metabolic disorders in which there is lipid accumulation in various cell types, including the central nervous system, because of the deficiency of a variety of enzymes. " 05/01/1995 - "Enzymes utilizing fat in the macrophages were not revealed at early stages of lipoidosis. " 11/01/1994 - "From 1975 to 1993, the activity of various lysosomal enzymes was determined in the leukocytes, cultured skin fibroblasts, or hair roots from 5,594 patients, mainly children, in whom the diagnosis of a lipidosis was suspected. " 01/01/1967 - "[On the problem of the relationship between the activity of lipolytic enzymes and lipoidosis of the aortic wall]." 02/01/1958 - "Cerebrospinal fluid enzymes in central nervous system lipidoses (with particular reference to amaurotic family idiocy)."
6.	mustard oilIBA 09/01/1981 - "The inclusion of fish oil or fish oil plus carnitine in a mustard oil diet, especially the latter, eliminated the histopathologically detectable lipidosis in heart and skeletal muscles. " 09/01/1979 - "Effect of mustard oil, rapeseed oil & groundnut oil feeding on development of myocardial lipidosis & fibrosis in rats." 09/01/1981 - "The effects of short-term feeding of a 20% mustard oil (containing 47% erucic acid) diet with 0.1% carnitine and/or fish oil on the activity of enzymes of lipid metabolism in mitochondrial and post-mitochondrial fractions of heart, liver, and skeletal muscles of rats were determined to study the reversal of erucic acid-induced lipidosis. "
7.	Amantadine (Aman)FDA LinkGeneric 04/01/1987 - "It is suggested that the cage-like structure of the amantadine molecule hinders an effective intercalation of the drug into phospholipid aggregates, and that this is an essential factor responsible for the low inherent efficacy of amantadine with respect to lipidosis induction." 04/01/1987 - "Amantadine-induced lipidosis. " 04/01/1987 - "The present study has revealed a parallel between the comparatively low lipidosis-inducing efficacy inherent to amantadine and the comparatively low tendency to interact with phospholipids. " 04/01/1987 - "The purpose of this study was to test whether or not the antiviral drug amantadine induces the structural features of lipidosis in intact animals (rats) and cultured cells, and to investigate the interactions between amantadine and phospholipids. " 04/01/1987 - "This was paralleled by the findings on cell cultures (rat peritoneal macrophages), where the lipidosis-inducing potency of amantadine was approximately 10-fold lower than that of chlorphentermine. "
8.	Lipoproteins (Lipoprotein)IBA 02/01/2014 - "Lipoprotein glomerulopathy may provide a key to unlock the puzzles of renal lipidosis." 12/01/2011 - "Based on these results, we diagnosed the glomerular lesion as glomerular lipidosis caused by uptake of low-density lipoprotein in mesangial cells. " 05/01/2011 - "Lipoprotein glomerulopathy (LG), briefly described in a patient of Koitabashi in 1987 in a review on renal lipidoses authored by Faraggiana and Churg, represents an emerging novel storage renal disease. " 10/01/2010 - "Changes of very low-density lipoprotein concentration in hepatic blood from cows with fasting-induced hepatic lipidosis." 12/01/1998 - "Characterization of serum lipoprotein profiles of healthy, adult cats and idiopathic feline hepatic lipidosis patients."
9.	Insulin (Novolin)FDA Link 08/01/2008 - "Despite hepatic lipidosis, treatment resulted in improved insulin signaling in the liver, muscle, and adipose tissue. " 08/01/2006 - "Decreased insulin response may be an important complication of negative energy balance and hepatic lipidosis." 08/01/2006 - "Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis." 03/01/2002 - "However, in terms of preventing hepatic lipidosis, the anti-lipolytic effect of insulin on adipose tissue, which results in decreased mobilization of and hence hepatic load with LCFA, appears more important." 10/01/2006 - "Cows with hepatic lipidosis and ketosis have low tissue responsiveness to insulin owing to ketoacidosis. "
10.	Glucose (Dextrose)FDA LinkGeneric 07/01/1997 - "Serum glucose and total carbon dioxide concentrations were significantly lower in cattle with severe lipidosis than in those with mild or moderate lipidosis, and low serum glucose or total carbon dioxide concentrations were rare in cattle without severe lipidosis. " 10/01/2003 - "Carnitine improved fatty acid oxidation and glucose utilization during weight loss without correcting hepatic lipidosis. " 11/01/2012 - "These findings do not necessarily imply that olanzapine is directly associated with a risk of impairment of weight gain, glucose metabolism disturbances and lipidosis. " 11/01/2012 - "On the other hand, olanzapine has many reports of causing weight gain, glucose metabolism disturbances and lipidosis. " 10/01/2006 - "In addition to the major replacement therapy to alleviate severity of negative energy balance, administration of insulin with concomitant delivery of dextrose increases efficiency of treatment for hepatic lipidosis and ketosis. "

Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 12/01/1995 - "Since a successful bone marrow transplantation (BMT) for Hurler's disease reported in 1981, BMT has been established as an effective treatment for lysosomal storage diseases such as mucopolysaccharidosis or lipidosis. " 07/01/1999 - "Niemann-Pick disease type C (a cellular cholesterol lipidosis) treated by bone marrow transplantation."
2.	Surgical Portasystemic Shunt (Portosystemic Shunt) 11/01/2014 - "This preliminary study suggests that the presence of hepatic lipidosis and LG has no demonstrable effect on development of acquired shunts or the magnitude of increase in liver volume after attenuation of congenital extrahepatic portosystemic shunts in dogs."
3.	Nutritional Support (Artificial Feeding) 08/01/2012 - "Therapy is similar to that used in dogs, with added emphasis on early nutritional support to prevent hepatic lipidosis. " 11/15/2000 - "Nutritional support for treatment of hepatic lipidosis in a llama." 09/01/2014 - "As cats are intolerant of prolonged periods of inadequate nutritional intake, especially given their propensity to develop hepatic lipidosis, their increased requirements for amino acids, and inability to slow their rate of gluconeogenesis, symptomatic therapy and nutritional support is often required during diagnostic investigations. "
4.	Transplants (Transplant) 11/01/2009 - "Early complications occurred in 8/14 eyes and included anterior uveitis (7/14), corneal ulceration (5/14), marked corneal granulation tissue at the graft margin (2/14), dyscoria (2/14), corneal lipidosis (1/14) and corneal oedema (1/14). " 02/01/2012 - "Furthermore, GPCS/DNA complexes showed higher levels of GFP expression in the liver in model mice after intravenous injection than naked DNA and metoxy-poly(ethylene glycol)-chitosan-graft-spermine as controls without remarkable fibrosis, inflammation, lipidosis, or necrosis. "
5.	Protein-Restricted Diet (Diet, Protein Restricted) 01/01/1989 - "The liver lipidosis observed during lactation, in contrast to that observed during growth with a low protein diet, was not due to a threonine deficiency." 01/01/1989 - "Inositol supplementation, but not choline supplementation, strongly reduced, in the case of a low protein diet, and suppressed, in the case of a sufficient protein diet, this lipidosis." 01/01/1989 - "During lactation a methionine supplemented low protein diet or a sufficient protein diet containing 40% of fructose induced an important hepatic lipidosis. "