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Thioctic Acid (Lipoic Acid)

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An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Also Known As:

Lipoic Acid; Aliud Brand of Thioctic Acid; Alpha-Lipogamma; Alpha-Lipon Stada; Alpha-Liponsaure Sofotec; Alpha-Lippon AL; Alphaflam; Azulipont; Azupharma Brand of Thioctic Acid; Fenint; Generosan Brand of Thioctic Acid; Heumann Brand of Thioctic Acid; Hexal Brand of Thioctic Acid; Illa Brand of Thioctic Acid; Illa Brand of Thioctic Acid Tromethamine; Juta Brand of Thioctic Acid; Juthiac; Lichtenstein Brand of Thioctic Acid; Liponsaure-ratiopharm; MTW Brand of Thioctic Acid; MTW-Alphaliponsaure; Merck dura Brand of Thioctic Acid; Neurium; Pharmacia Brand of Thioctic Acid; Pleomix-Alpha; Pleomix-Alpha N; Q-Pharm Brand of Thioctic Acid; Rosen Brand of Thioctic Acid; Sofotec Brand of Thioctic Acid; Stadapharm Brand of Thioctic Acid; Thioctacid; Thioctacide T; Thiogamma Injekt; Thiogamma oral; Tromlipon; Trommsdorgg Brand of Thioctic Acid; Verla Brand of Thioctic Acid; Verla-Lipon; Viatris Brand of Thioctic Acid; Viatris Brand of Thioctic Acid Tromethamine; Worwag Brand of Thioctic Acid; Worwag Brand of Thioctic Acid Meglumine; alpha-Lipoic Acid; alpha-Liponaure Heumann; alpha-Liponsaure von ct; alpha-Vibolex; biomo Brand of Thioctic Acid; biomo-lipon; ct-Arzneimittel Brand of Thioctic Acid; duralipon; espa-lipon; esparma Brand of Thioctic Acid; ratiopharm Brand of Thioctic Acid; Acid, alpha-Lipoic; Alpha Lipogamma; Alpha Lipon Stada; Alpha Liponsaure Sofotec; Alpha Lippon AL; AlphaLipogamma; AlphaLipon Stada; AlphaLiponsaure Sofotec; AlphaLippon AL; Injekt, Thiogamma; Liponsaure ratiopharm; Liponsaureratiopharm; MTW Alphaliponsaure; MTWAlphaliponsaure; Pleomix Alpha; Pleomix Alpha N; PleomixAlpha; PleomixAlpha N; Q Pharm Brand of Thioctic Acid; Verla Lipon; VerlaLipon; alpha Lipoic Acid; alpha Liponaure Heumann; alpha Liponsaure von ct; alpha Vibolex; alphaLiponaure Heumann; alphaLiponsaure von ct; alphaVibolex; biomo lipon; biomolipon; ct Arzneimittel Brand of Thioctic Acid; espa lipon; espalipon; 1,2-Dithiolane-3-pentanoic acid

Networked: 1111 relevant articles (152 outcomes, 268 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Varalakshmi, Palaninathan: 13 articles (10/2007 - 04/2004)
2.	Lee, Ki-Up: 12 articles (01/2012 - 07/2004)
3.	Selvakumar, Elangovan: 11 articles (01/2008 - 12/2004)
4.	Prahalathan, Chidambaram: 10 articles (05/2006 - 12/2004)
5.	Rassokhina, L M: 9 articles (03/2015 - 01/2008)
6.	Bourdette, Dennis N: 9 articles (07/2011 - 10/2002)
7.	Lee, In-Kyu: 8 articles (12/2014 - 07/2004)
8.	Khan, Bobby V: 8 articles (02/2014 - 01/2005)
9.	Moreno-Aliaga, María J: 7 articles (03/2015 - 06/2011)
10.	Pérez-Matute, Patricia: 7 articles (03/2015 - 06/2011)

Related Diseases

1.	Diabetic Neuropathies (Diabetic Neuropathy) 06/01/2008 - "Alpha-lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously. " 07/01/2005 - "Moreover, given the potential role of oxidative stress in the pathogenesis of secondary complications in diabetes, alpha-lipoic acid might be beneficial in the prevention/treatment of these complications as was recently shown for diabetic neuropathy." 12/01/2000 - "Lipoic acid supplementation has been found to be beneficial in preventing neurovascular abnormalities in diabetic neuropathy. " 06/01/2005 - "The results of our study demonstrate that alpha-lipoic acid appears to be an effective drug in the treatment for not only peripheral and autonomic diabetic neuropathy, but also diabetic mononeuropathy of the cranial nerves leading to full recovery of the patients." 01/01/1999 - "Here we review the current evidence from the clinical trials that assessed the therapeutic efficacy and safety of thioctic acid in diabetic polyneuropathy. "
2.	Burning Mouth Syndrome (Syndrome, Burning Mouth) 05/01/2009 - "Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: a double-blind, randomized, placebo-controlled study." 01/01/2009 - "To study the efficacy of alpha lipoic acid (ALA) in a group of patients with burning mouth syndrome (BMS). " 01/01/2009 - "Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study." 11/01/2004 - "Burning mouth syndrome: the efficacy of lipoic acid on subgroups." 03/01/2009 - "Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial."
3.	Reperfusion Injury 05/15/2012 - "New α-lipoic acid derivative, DHL-HisZn, ameliorates renal ischemia-reperfusion injury in rats." 10/30/2012 - "Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling." 01/01/1992 - "These results show that dietary supplementation with thioctic acid in vivo provides protection against ischemia/reperfusion injury in the Langendorff heart model." 11/01/2014 - "Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury." 06/01/2007 - "The aim of this study was to characterize the in vivo action of lipoic acid (LA) in hepatic ischemia/reperfusion injury (IRI) and its effects on liver regeneration involving the investigation of mechanisms of action and effects on animal survival. "
4.	Body Weight (Weight, Body) 12/01/1993 - "alpha-Lipoic acid (alpha-LA) improved longer-term memory of aged female NMRI mice in the habituation in the open field test at a dose of 100 mg/kg body weight for 15 days. " 06/01/2012 - "The purpose of this study was to investigate the effects of α-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). " 01/01/2011 - "The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects. " 03/01/2009 - "Therefore, the aim of the present study was to investigate the effects of supplementation of a standard or high fat diet with the antioxidant lipoic acid (LA) during 56 days, on body weight gain, adiposity, feed efficiency and intestinal sugar absorption, in male Wistar rats. " 02/01/2015 - "Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. "
5.	Ischemia 01/01/2007 - "Since lipoic acid administration alleviated the I/R-induced liver injury and improved the hepatic structure and function, it seems likely that lipoic acid with its antioxidant and oxidant-scavenging properties may be of potential therapeutic value in protecting the liver against oxidative injury due to ischemia-reperfusion." 07/21/2007 - "Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model." 04/01/2015 - "Protective effect of alpha lipoic acid (ALA) on sciatic nerve following ischemia-reperfusion in rats was investigated by using light microscopy and biochemical methods. " 06/01/2014 - "Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts." 05/01/2014 - "The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model."

Related Drugs and Biologics

1.	Thioctic Acid (Lipoic Acid)
2.	Antioxidants
3.	Glucose (Dextrose)
4.	Insulin (Novolin)
5.	Vitamin E
6.	Ascorbic Acid (Vitamin C)
7.	coenzyme Q10 (CoQ10)
8.	NAD (NADH)
9.	Curcumin
10.	Glutathione (Reduced Glutathione)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Fat-Restricted Diet (Diet, Fat Restricted)
3.	Trabeculectomy (Trabeculoplasty)
4.	Therapeutics
5.	Immunotherapy