Lipid Peroxides

Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.

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Networked: 2090 relevant articles (75 outcomes, 221 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nadeem, Ahmed: 9 articles (02/2021 - 02/2005)
2.	Ahmad, Sheikh F: 8 articles (02/2021 - 05/2015)
3.	Al-Harbi, Naif O: 8 articles (02/2021 - 05/2015)
4.	Celik, Hakim: 8 articles (05/2014 - 04/2007)
5.	Das, Undurti N: 7 articles (01/2019 - 01/2007)
6.	Devaki, Thiruvengadam: 7 articles (04/2016 - 06/2006)
7.	Lankin, V Z: 7 articles (01/2009 - 07/2000)
8.	Aksoy, Nurten: 6 articles (11/2014 - 01/2008)
9.	Erel, Ozcan: 6 articles (05/2014 - 03/2007)
10.	Harangi, Mariann: 6 articles (10/2011 - 04/2002)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2015 - "Oral preadministration of extracts of Salacia leaves and stems at doses of 100, 200 and 400 mg/kg body weight prevented the elevations of lipid peroxides and injury markers in a dose-dependent manner. " 09/01/2009 - "On the other hand, LA decreased food intake, body weight gain and induced oxidative stress as indicated by the significant changes in serum biochemical parameters and histological picture of liver and kidney and increased lipid peroxide and reduces GSH levels in liver tissues. " 03/01/2006 - "ETS presented smaller cardiac output (0.087 +/- 0.001 vs. 0.105 +/- 0.004 l/min; p = 0.007), higher left ventricular diastolic diameter (19.6 +/- 0.5 vs. 18.0 +/- 0.5 mm/kg; p = 0.024), higher left ventricular (2.02 +/- 0.05 vs. 1.70 +/- 0.03 g/kg; p < 0.001) and atrium (0.24 +/- 0.01 vs. 0.19 +/- 0.01 g/kg; p = 0.003) weight, adjusted to body weight of animals, and higher values of hepatic lipid hydroperoxide (5.32 +/- 0.1 vs. 4.84 +/- 0.1 nmol/g tissue; p = 0.031) than Air. " 03/01/2002 - "Body weight, blood pressure, serum NO2-/NO3-, lipid peroxides, blood viscosity, erythrocyte deformability and endothelium-dependent/-independent relaxation were measured. " 03/01/2000 - "Homozygous mutant Gpx1(tm1Mgr) mice have 20% less body weight than normal animals and increased levels of lipid peroxides in the liver. "
2.	Inflammation (Inflammations) 10/01/2011 - "The purpose of the present study was to investigate whether the generation of lipid peroxide in periodontal inflammation could induce tissue injury in the liver, heart, kidney and brain using a rat model. " 01/01/2019 - "MS1:3-H alleviated oxidative stress with lower hepatic lipid peroxide compared to MS1:5-H whereas MS1:5-H ameliorated inflammation and hepatocyte damage better than MS1:3-H. " 11/20/2018 - "The results showed that Mat-treated mice were more resistant to steatosis in the liver than vehicle-treated mice and that Mat significantly reduced hepatic inflammation, lipid peroxides. " 10/01/2011 - "The results reveal that excessive production of lipid peroxide following periodontal inflammation is involved in oxidative DNA damage of the brain, heart, liver and kidney." 10/01/2011 - "Gingival response to periodontal inflammation generates excessive lipid peroxide and such a condition may augment systemic health through increased circulating lipid peroxide. "
3.	Neoplasms (Cancer) 01/01/2022 - "STATEMENT OF SIGNIFICANCE: The therapeutic efficacy of ferroptosis has been far from satisfactory due to high GSH level and insufficient lipid peroxide production in cancer cells. " 07/01/2023 - "Importantly, SOR@TF-Fe3+ NVs were more effective in promoting the accumulation of lipid peroxides (LPO), inhibiting tumor proliferation, and prolonging survival rates in HCC mouse model than SOR and TF- Fe3+ NVs alone. " 04/01/2023 - "In this study, we proposed a novel method of inducing lipid peroxide (LPO) of the cancer cell membrane, whose performance is not limited by the pH value and H2O2 in the TME. " 01/01/1993 - "These studies indicate that a linear relationship exists between the increasing number of esophageal tumors and increasing levels of lipid peroxide products that are formed during FR activity. " 09/12/2023 - "The results showed that MWA combined with PFP-Apa-MOF clearly enhanced the ablation efficiency, leading to apparent tumor inhibition, and increased tumor apoptosis and lipid peroxide. "
4.	Necrosis 01/01/2021 - "Ferroptosis is a type of oxidative stress-dependent regulated necrosis characterized by excessive lipid peroxide accumulation. " 07/01/2004 - "A dose (100-1000 mg kg(-1)) dependent reduction in percent left ventricle necrosis (PLVN) as well as in lipid peroxide levels was observed in rats treated with alcoholic extract of Hydrocotyle asiatica L. " 01/01/1981 - "Of these heavy drinkers, cases with a remarkably high level of liver lipoperoxide showed a high incidence of hepatic cell necrosis. " 10/01/2023 - "Ferroptosis is a programmed cell death (different from apoptosis and necrosis) mainly caused by an imbalance in the generation and degradation of intracellular lipid peroxides due to iron overload. " 12/01/1996 - "The effect of lipid peroxide on osteoblasts and vascular endothelial cells--the possible role of ischemia-reperfusion in the progression of avascular necrosis of the femoral head."
5.	Reperfusion Injury 04/01/1999 - "After 1 hour of reperfusion, gas exchange function (p < 0.01), tissue lipid peroxide levels (p < 0.05) and histologic damage in reperfused lung allografts (p< 0.05) were significantly improved in lazaroid-treated group IV compared with control group I. These findings suggest that lazaroid U74389G ameliorates ischemia-reperfusion injury in rat lung transplants by inhibiting lipid peroxidation." 12/01/2002 - "In the pathogenesis of intestinal ischemia-reperfusion injury, the measurement of lipid peroxides needs to be established. " 08/01/2000 - "IP can attenuate ischemia/reperfusion injury by alleviating lipid peroxide and decreasing apoptosis of hepatocytes." 04/01/1992 - "These results suggest that postoperative increases in lipid peroxide concentrations can be of multifactorial origin and may be an indication of reperfusion injury to the myocardium. " 06/01/1994 - "An experimental study was conducted to investigate the prevention of reperfusion injury after testicular torsion through changes in the lipid peroxide content of the testis. "

Related Drugs and Biologics

1.	Antioxidants
2.	Free Radicals
3.	Enzymes
4.	Superoxide Dismutase
5.	Glutathione (Reduced Glutathione)
6.	Messenger RNA (mRNA)
7.	alpha-Tocopherol
8.	Catalase
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Ligation
4.	Intravenous Injections
5.	Aftercare (After-Treatment)