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Lipase (Acid Lipase)

An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.

Also Known As:

Acid Lipase; Triacylglycerol Lipase; Acid Lipase A; Acid Lipase B; Acid Lipase I; Acid Lipase II; Exolipase; Monoester Lipase; Triacylglycerol Hydrolase; Triglyceridase; Triolean Hydrolase; A, Acid Lipase; B, Acid Lipase; Hydrolase, Triacylglycerol; Hydrolase, Triolean; I, Acid Lipase; II, Acid Lipase; Lipase A, Acid; Lipase B, Acid; Lipase I, Acid; Lipase II, Acid; Lipase, Acid; Lipase, Monoester; Lipase, Triglyceride; Tributyrinase; Triglyceride Lipase; Triacylglycerol acylhydrolase

Networked: 3110 relevant articles (97 outcomes, 256 trials/studies)

Relationship Network

Drug Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Carboxylic Ester Hydrolases: 40
        Lipase: 3110
        Pancrelipase: 135
        vasoelastine: 15
        human hepatic lipase: 8
        Pankreon: 6
        Aeromonas hydrophilia lipase-acyltransferase: 5
        Nutrizym: 5
        Pancrex V: 4
        human gastric lipase: 3
        pancreatic lipase related protein 2: 3
        Novozyme 435: 2
        ALTU-135: 1
        Candida antarctica lipase B: 1
        lipase foldase: 1
        pancreatic lipase-related protein 1: 1
        solysime: 1
        Arabidopsis At2g31690 protein
        BCR 693
        BCR 694
        C elegans ATGL-1 protein
        Candida rugosa Lip4 protein
        Capra hircus BUSgp60 protein
        Chromobacterium viscosum lipase
        Clostridium novyi liposomase
        Geotrichum candidum lipase II
        Geotrichum candidum lipase III
        human adiponutrin
        human CEL protein
        human LIPG protein
        human LIPH protein
        human PNLIP protein
        human PNPLA1 protein
        human PNPLA2 protein
        human PNPLA4 protein
        human PNPLA5 protein
        lipase II
        Lipozyme
        Malassezia furfur LIP1 protein
        mouse Lipc protein
        mouse Lipg protein
        nortase
        novozyme 677BG
        pregastric esterase
        Pseudomonas chlororaphis pueA protein
        Pseudomonas lactonizing lipase protein
        Pseudomonas LipA protein
        Pseudomonas LipB protein
        rat hepatic lipase
        rat Lipg protein
        S cerevisiae TGL3 protein
        S cerevisiae Tgl4 protein
        S cerevisiae Tgl5 protein
        Staphylococcus warneri lipase 2
        thermostable lipase
        Vibrio cholerae HlyC lipase
        Yarrowia lipolytica LIP2 protein

Experts

1.	Park, Sung-Joo: 16 articles (05/2015 - 08/2005)
2.	Cuzzocrea, Salvatore: 16 articles (07/2012 - 05/2002)
3.	Song, Ho-Joon: 15 articles (05/2015 - 02/2006)
4.	Steiner, Jörg M: 15 articles (01/2015 - 09/2003)
5.	Mazzon, Emanuela: 13 articles (07/2012 - 05/2002)
6.	Di Paola, Rosanna: 13 articles (05/2012 - 09/2003)
7.	Tomaszewska, R: 13 articles (10/2010 - 10/2001)
8.	Cravatt, Benjamin F: 12 articles (07/2015 - 01/2010)
9.	Bae, Gi-Sang: 12 articles (05/2015 - 10/2008)
10.	Warzecha, Z: 12 articles (10/2010 - 10/2001)

Related Diseases

1.	Pancreatitis 09/01/2012 - "As there is currently no gold standard for antemortem diagnosis of pancreatitis in dogs and cats, the combination of a complete history and physical examination, measurement of pancreatic lipase immunoreactivity, and ultrasonographic examination of the pancreas is the best approach for an accurate noninvasive diagnosis of pancreatitis." 11/01/1981 - "The results of this study also showed that low serum lipase values almost always eliminated the possibility of pancreatitis and that high values were often, but not always, diagnostic for pancreatitis." 04/01/1984 - "The turbidimetric test was helpful for rapid quantitative determination of serum lipase and thus for the early and accurate diagnosis of acute pancreatitis." 05/01/2014 - "Development of a feline-specific pancreatic lipase immunoassay has improved our diagnostic ability in the past decade, but may have more limited application for mild and chronic forms of pancreatitis. " 08/01/2015 - "Serum lipase is now the preferred test due to its improved sensitivity, particularly in alcohol-induced pancreatitis. "
2.	Body Weight (Weight, Body) 07/01/2015 - "Whereas, the administration of CA to HFD-fed rats improved the body weight gain and serum lipid profile and reverted back near to normal the activities of lipase and ACE. " 12/01/2015 - "This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. " 11/12/2009 - "Taken together, the results of the present study suggest that long-term, daily administration of PF-W successfully suppressed body weight gain-apparently due to accelerated intestinal transit and not to interference with pancreatic lipase activity. " 11/12/2009 - "PF-W was used in following experiments: 10-week-long measurement of body weight and food intake, in vitro pancreatic lipase activity assay, in vivo triglyceride concentration study, and measurement of intestinal transit rate. " 12/01/2015 - "The administration of CNSP decreases the body weight and inhibits lipase activity of obese rats in serum and intestine as compared with untreated HDF-rats. "
3.	Hypertriglyceridemia 05/01/2012 - "Previous studies demonstrated that loss-of-function mutations of Lmf1 result in diminished lipase activity and severe hypertriglyceridemia in mice and human subjects. " 06/01/2010 - "Recent studies identified mutations in LMF1 that cause combined lipase deficiency and hypertriglyceridemia in humans. " 03/01/2015 - "Refeeding intolerance occurs in 12.4% patients with mild AP and appears more often in those with hypertriglyceridemia-induced AP, elevated serum lipase (>2-fold of the upper limit of normal) before refeeding, and immediate feeding." 03/01/2015 - "In the final regression model, hypertriglyceridemia-induced AP (odds ratio, 7.72; 95% CI: 2.50-23.82, P < 0.001), elevated serum lipase (>2-fold of the upper limit of normal) before refeeding (odds ratio, 2.13; 95% CI: 1.2-3.77, P = 0.009), and immediate feeding (odds ratio, 1.75; 95% CI: 1.31-2.33, P < 0.001) were critical risk factors of refeeding intolerance. " 03/01/2015 - "Further investigation revealed severe hypertriglyceridemia (4,009 mg/dL) and elevated lipase (1,714 U/L). "
4.	Obesity 02/15/2013 - "Inhibition of pancreatic lipase is effective for a prevention of obesity. " 01/01/2014 - "Along with HTS based screening, detailed structure-activity relationship studies on semi-synthetic and synthetic derivatives might also provide a direction for the development of potential lead(s) or pharmacophore for pancreatic lipase inhibition in order to treat and/or prevent obesity and related disorders. " 08/09/2010 - "This study evaluated anti-obesity effect of the ethanolic extract of Morus bombycis root on lipase activity and lipolysis in adipocytes and adipose tissues. " 01/01/2008 - "In this study the inhibitory activities of dandelion (Taraxacum officinale) against pancreatic lipase in vitro and in vivo were measured to determine its possible use as a natural anti-obesity agent. " 10/01/2001 - "Based on the inhibitory effects of teasaponin on pancreatic lipase activity in vitro, this study was performed to clarify whether teasaponin prevented obesity induced in mice by a high-fat diet for 11 weeks. "
5.	Cystic Fibrosis (Mucoviscidosis) 08/01/2004 - "Among indirect tests, faecal elastase-1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis." 08/01/2004 - "Faecal elastase-1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis." 01/01/1992 - "Therapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis." 04/01/1998 - "The study evaluates faecal immunoreactive lipase (IRL) measurement in spot stool samples as an index of exocrine pancreatic function in patients with cystic fibrosis (CF). " 05/28/1983 - "A study was undertaken to discover whether activity of pancreatic lipase is also altered in cystic fibrosis. "

Related Drugs and Biologics

1.	Amylases
2.	Lipoprotein Lipase (Diacylglycerol Lipase)
3.	Lipoproteins (Lipoprotein)
4.	orlistat (Xenical)
5.	Caerulein (Ceruletide)
6.	Enzymes
7.	Cholesterol
8.	Proteins (Proteins, Gene)
9.	Pancrelipase (Creon)
10.	Creatinine

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Total Parenteral Nutrition
3.	Injections
4.	Fat-Restricted Diet (Diet, Fat Restricted)
5.	Plasma Exchange