Linitis Plastica

A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a "leather bottle" shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach.

Networked: 59 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer)
2.	Fibrosis (Cirrhosis)
3.	Adenocarcinoma
4.	Neoplasms (Cancer)
5.	Non-Hodgkin Lymphoma (Lymphosarcoma)

Experts

1.	Saigenji, Katsunori: 2 articles (07/2007 - 06/2006)
2.	Tanabe, Satoshi: 2 articles (07/2007 - 06/2006)
3.	Higuchi, Katsuhiko: 2 articles (07/2007 - 06/2006)
4.	Koizumi, Wasaburo: 2 articles (07/2007 - 06/2006)
5.	Sasaki, Tohru: 2 articles (07/2007 - 06/2006)
6.	Sen, Rajeev: 1 article (04/2015)
7.	Dhull, Anil Kumar: 1 article (04/2015)
8.	Pal, Manoj: 1 article (04/2015)
9.	Dhankhar, Rakesh: 1 article (04/2015)
10.	Lathwal, Amit: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Linitis Plastica:

1.	Cisplatin (Platino)FDA LinkGeneric 06/01/2013 - "We conducted a phase II study to evaluate the safety and efficacy of preoperative chemotherapy with S-1 + cisplatin followed by gastrectomy in patients with linitis plastica (type 4) or large ulcero-invasive-type (type 3) gastric cancer. "
2.	BariumIBA 09/01/2010 - "Linitis plastica with lymph node involvement was suspected by gastroscopy, barium meal and endoscopic ultrasonography but was not confirmed by gastric biopsies. " 10/01/2006 - "Linitis plastica with lymph node involvement was suspected by gastroscopy, barium meal and endoscopic ultrasonography but was not confirmed by gastric biopsies. " 02/01/2005 - "Linitis plastica of the rectum is an uncommon entity that is difficult to diagnose due to the lack of mucosal lesions on endoscopy, the low diagnostic yield of biopsy and non-specific findings of barium radiology and computerized tomography. " 03/01/1988 - "Although the usual primary site is the stomach in case of linitis plastica, invasion of the large and small bowel is rarely seen, but must be searched with proctoscopic exam and barium enema. " 11/01/1996 - "Of 34 cases of non-Hodgkin lymphoma of the stomach in the radiologic archives of the Armed Forces Institute of Pathology, nine had a linitis plastica appearance at barium study. "
3.	Fluorouracil (Carac)FDA LinkGeneric 01/01/1996 - "We report herein the cases of four patients with primary linitis plastica of the rectum who underwent surgery, followed by intensive postoperative chemotherapy using 5-fluorouracil (5-FU) derivatives in our institution. " 07/01/2007 - "S-1 showed a higher response rate for undifferentiated-type adenocarcinoma, and S-1 alone or its combination regimens demonstrated greater anti-tumor effects and longer survival time for gastric linitis plastica compared with conventional 5-FU regimens in our historical control study (response rate: S-1/non S-1 57.9%/27.9%, p<0.01; MST: S-1/non S-1 402 days/213 days, p<0.01). "
4.	titanium silicide (TS-1)IBA 06/01/2006 - "TS-1 as first-line therapy for gastric linitis plastica: historical control study."
5.	tranilast (N 5')IBA 11/01/1996 - "Images from barium studies revealed a linitis plastica appearance with narrowing of the gastric antrum and/or body (n = 5), narrowing of the body and/or fundus (n = 3), and diffuse gastric narrowing (n = 1). "
6.	Transforming Growth Factor beta (TGF-beta)IBA 07/01/1991 - "These results suggest that the activated form of TGF-beta released from gastric scirrhous carcinoma cells stimulates fibroblasts to contract the collagenous stroma of the stomach wall, which leads to the so-called "linitis plastica" stomach condition." 06/01/1992 - "From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-beta in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer." 11/01/1990 - "From these findings, it was assumed that the immunological staining of EGF and TGF-beta in biopsy specimens might be useful in the diagnosis of the pen type of early gastric cancer and also in diagnosis of early lesion of linitis plastica type gastric cancer."
7.	N-Acetylneuraminic Acid (Sialic Acid)IBA 11/01/1991 - "Acid mucopolysaccharides (AMPS) and sialic acid were histochemically detected in the interstitial tissues of early gastric carcinomas and linitis plastica type gastric cancers. " 06/01/1991 - "Acid mucopolysaccharides (AMPS) and sialic acid were histochemically detected in the interstitial tissues of early gastric carcinomas and linitis plastica type gastric cancers. "
8.	GlycosaminoglycansIBA 11/01/1991 - "Acid mucopolysaccharides (AMPS) and sialic acid were histochemically detected in the interstitial tissues of early gastric carcinomas and linitis plastica type gastric cancers. " 06/01/1991 - "Acid mucopolysaccharides (AMPS) and sialic acid were histochemically detected in the interstitial tissues of early gastric carcinomas and linitis plastica type gastric cancers. "
9.	Epidermal Growth Factor (EGF)IBA 06/01/1992 - "From these findings, it was assumed that the immunohistochemical staining of EGF and TGF-beta in endoscopic biopsy specimens was useful for the diagnosis of the PEN type of gastric cancer and also for the diagnosis of the initial lesion of linitis plastica-type gastric cancer." 11/01/1990 - "From these findings, it was assumed that the immunological staining of EGF and TGF-beta in biopsy specimens might be useful in the diagnosis of the pen type of early gastric cancer and also in diagnosis of early lesion of linitis plastica type gastric cancer."
10.	Colloids (Colloid)IBA 05/26/1956 - "[Colloid cancer; its relation to linitis plastica]." 05/26/1956 - "[Two types of infiltrating cancer of the stomach; linitis plastica and gastric colloid epithelioma]."

Therapies and Procedures

1.	Gastrectomy 03/01/1989 - "Seventeen percent of cases were linitis plastica and required total gastrectomy in 77% of resections; only 13% of patients had curative operations; none were cured. " 10/01/1989 - "Total gastrectomy for linitis plastica should be performed in those patients who have disease limited to the stomach or regional lymph nodes. " 03/24/1956 - "[Gastrectomy in a case of linitis plastica]." 04/01/1955 - "[A case of linitis plastica; subtotal gastrectomy]." 03/01/1955 - "Total gastrectomy for linitis plastica."
2.	Drug Therapy (Chemotherapy) 03/28/2015 - "The 12 gastric linitis plastica and 6 lymphoma patients received chemotherapy and avoided surgery. " 12/01/2013 - "In contrast, older patients (70-79 years: ORadj 0.3, P < 0.001; 80+ years: ORadj 0.02, P < 0.001), patients with comorbidity (ORadj 0.6, P = 0.03), linitis plastica (ORadj 0.5, P = 0.03) and multiple distant metastases (ORadj 0.5, P = 0.01) were less often treated with chemotherapy. " 06/01/1996 - "Signet-ring cell adenocarcinoma or linitis plastica of the bladder has a highly malignant course despite neoadjuvant chemotherapy and total cystectomy." 01/01/1987 - "[A case report of patient with advanced stomach carcinoma of linitis plastica type responding to multi-immunotherapy and chemotherapy]." 01/01/1996 - "We report herein the cases of four patients with primary linitis plastica of the rectum who underwent surgery, followed by intensive postoperative chemotherapy using 5-fluorouracil (5-FU) derivatives in our institution. "
3.	Jejunostomy 11/01/1911 - "VIII. Linitis Plastica (Cirrhosis of Stomach): With a Report of a Case Cured by Gastro-Jejunostomy."
4.	Laparotomy 09/01/2004 - "Peritoneal washings were obtained during laparotomy from 47 consecutive linitis plastica patients who preoperatively were considered candidates for curative resection. " 01/01/1997 - "On exploratory laparotomy, the whole of the stomach was found to be grossly shrunken with thickening of the walls suggesting a "linitis plastica" stomach. " 10/01/1989 - "Finally, laparotomy with full-thickness biopsies of the stomach and colon revealed linitis plastica. "
5.	Esophagectomy 12/01/1988 - "Esophagectomy and esophagogastrostomy revealed a diffusely infiltrating adenocarcinoma ("linitis plastica") of the distal esophagus, sparing the gastroesophageal junction and stomach. "