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Lincomycin (Lincocin)

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Also Known As:

Lincocin; Epilincomycin; Lincomycin A; Lincomycin Hydrochloride; Lincomycin Monohydrochloride; Lincomycin Monohydrochloride, (2S-cis)-Isomer; Lincomycin Monohydrochloride, (L-threo)-Isomer; Lincomycin Monohydrochloride, Hemihydrate; Lincomycin, (L-threo)-Isomer; Hemihydrate Lincomycin Monohydrochloride; Lincolnensin; Lincomycin, (2S-cis)-Isomer; D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-

Networked: 360 relevant articles (36 outcomes, 33 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Berry, Steven L: 2 articles (09/2012 - 09/2010)
2.	Famula, Thomas R: 2 articles (09/2012 - 09/2010)
3.	Read, Deryck H: 2 articles (09/2012 - 09/2010)
4.	Eskridge, Kent M: 1 article (01/2016)
5.	Hodges, Laurie: 1 article (01/2016)
6.	Zhang, Yuping: 1 article (01/2016)
7.	Bartelt-Hunt, Shannon L: 1 article (01/2016)
8.	Sallach, J Brett: 1 article (01/2016)
9.	Li, Xu: 1 article (01/2016)
10.	Snow, Daniel D: 1 article (01/2016)

Related Diseases

1.	Infection 03/01/1981 - "Therefore parenteral lincomycin in children appears to be a safe and effective antibiotic when used for infections due to Gram-positive cocci." 01/01/1972 - "Two chlorinated lincomycin analogues tested in this host-parasite system cured blood-induced infections. " 03/01/1972 - "[Experimental studies on lincomycin in anaerobic (gaseous) infection]." 09/01/2010 - "Lincomycin (LIN) is an antibiotic widely used in veterinary medicine to cure infections caused by Gram-positive pathogens. " 01/01/1993 - "[The clinical use of lincomycin in treating anaerobic infection in patients with surgical abdomen]."
2.	Dysentery 07/01/1978 - "All concentrations of lincomycin were effective for the treatment of swine dysentery by oral or by contact exposure. " 07/01/1978 - "Three experimental studies were conducted in 232 growing pigs (8 to 12 weeks old) to evaluate the therapeutic effects of various concentrations of lincomycin in drinking water, against swine dysentery experimentally transmitted, by oral inoculation or by contact-commingling exposure. " 02/01/1981 - "Therapeutic effects of parenteral administration of lincomycin on experimentally transmitted swine dysentery." 10/01/1979 - "Lincomycin levels for treatment of swine dysentery." 07/01/1978 - "The suggested optimal concentration was 33 mg of lincomycin/L of drinking water for the treatment of swine dysentery."
3.	Weight Gain 10/01/2001 - "Based on the results of clinical observations (respiratory signs, rectal temperature, body weight gain, and feed conversion efficiency), macroscopic and histologic lesions of the lungs, and microbiologic findings, the best results were obtained by treatment of pigs with Econor + chlortetracycline, followed by Tetramutin, Pulmotil, Cyfac, and lincomycin + chlortetracycline." 12/08/1984 - "A field trial was carried out on clinically affected pigs, using tiamulin at 10 mg and 15 mg/kg bodyweight given by injection for three consecutive days, by comparing their weight gains and reduction in lameness scores during a seven day trial period (days 0 to 7) with those of negative untreated controls and positive controls injected with lincomycin at 10 mg/kg bodyweight for three days. " 06/01/1982 - "Pigs on the chlortetracycline-sulfamethazine-penicillin diet on the average tended to grow at a faster rate, attained a higher percentage weight gain, and weighed slightly more than pigs on either the lincomycin sulfate or no antibiotic diets. " 02/01/1987 - "Avoparcin, bacitracin methylenedisalisylic acid, efrotomycin, lincomycin, penicillin G procaine, and virginiamycin improved rate of weight gain and feed conversion of chicks and decreased cholyltaurine hydrolase activity in ileal homogenates relative to those of nonmedicated control birds. " 10/01/1984 - "In other experiments bacitracin, penicillin, chlortetracycline, oxytetracycline, erythromycin, tylosin, virginiamycin, lincomycin, bambermycins, and carbadox, all at a level of 55 ppm, improved weight gain and feed efficiency and significantly reduced the weight of the ileum and the number of C. "
4.	Mastitis 01/01/1989 - "Lincomycin is very useful for treating dairy herds with galt mastitis." 01/01/1989 - "Lincomycin has a good influence on mastitis caused by gram positive bacteria especially streptococci and staphylococci. " 01/01/1989 - "[Lincomycin therapy of streptococcal and staphylococcal mastitis in cattle]." 07/01/2004 - "This work describes a novel plasmid encoding resistance to lincomycin in a staphylococcal isolate associated with mastitis infection from dairy cows. " 03/01/2010 - "From December 2005 to August 2007, a total of 157 clinical mastitis cases on 10 farms in northern Germany were enrolled in the study and randomly assigned (blocked by parity and body temperature) to one of two treatment groups (intrammammary lincomycin/neomycin 1.5-d (ALK) or 5-d (ALL)). "
5.	Sinusitis 12/01/1990 - "[Clinical test on the efficacy of lincomycin administered by aerosol in acute sinusitis]." 12/01/1990 - "Twenty-seven patients with acute sinusitis have been treated with lincomycin by aerosol 600 mg once a day for 6 days. " 09/01/1973 - "[Treatment of chronic sinusitis with lincomycin]." 08/01/2012 - "The study suggests that lincomycin hydrochloride capsules, a conventional antibiotic indicates effective treatment for relief from tonsillitis and sinusitis, as compared to new third generation antibiotic." 12/01/1995 - "Thirty patients with chronic sinusitis have been treated with triadic nose drops consisting of ephedrine, dexamethason and lincomycin. "

Related Drugs and Biologics

1.	Spectinomycin (Spectinomycin Hydrochloride)
2.	Chlortetracycline (Aureomycin)
3.	Clindamycin (Cleocin)
4.	Virginiamycin
5.	Lincomycin (Lincocin)
6.	Anti-Bacterial Agents (Antibiotics)
7.	Penicillins (Penicillin)
8.	Gentamicins (Gentamicin)
9.	Amoxicillin (Wymox)
10.	Bacitracin (Baci-Rx)

Related Therapies and Procedures

1.	Absorbable Gelatin Sponge
2.	Retreatment
3.	Ovariectomy (Oophorectomy)
4.	Aftercare (After-Treatment)
5.	Drug Therapy (Chemotherapy)