Lincomycin (Lincocin)

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Also Known As:

Lincocin; Epilincomycin; Lincomycin A; Lincomycin Hydrochloride; Lincomycin Monohydrochloride; Lincomycin Monohydrochloride, (2S-cis)-Isomer; Lincomycin Monohydrochloride, (L-threo)-Isomer; Lincomycin Monohydrochloride, Hemihydrate; Lincomycin, (L-threo)-Isomer; Hemihydrate Lincomycin Monohydrochloride; Lincolnensin; Lincomycin, (2S-cis)-Isomer; D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-

Networked: 452 relevant articles (47 outcomes, 44 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Chen, Liang: 3 articles (05/2022 - 12/2020)
2.	Zhang, Hongfu: 3 articles (05/2022 - 12/2020)
3.	Zhang, Shunfen: 3 articles (05/2022 - 12/2020)
4.	Zhong, Ruqing: 3 articles (05/2022 - 12/2020)
5.	Han, Hui: 2 articles (05/2022 - 12/2020)
6.	Tang, Shanlong: 2 articles (05/2022 - 11/2021)
7.	Ajito, Keiichi: 2 articles (01/2021 - 01/2017)
8.	Hirai, Yoko: 2 articles (01/2021 - 01/2017)
9.	Kumura, Ko: 2 articles (01/2021 - 01/2017)
10.	Umemura, Eijiro: 2 articles (01/2021 - 01/2017)

Related Diseases

1.	Infections 01/01/1972 - "Two chlorinated lincomycin analogues tested in this host-parasite system cured blood-induced infections. " 03/01/1972 - "[Experimental studies on lincomycin in anaerobic (gaseous) infection]." 03/02/2023 - "Lincomycin is widely used in respiratory and gastrointestinal infection in veterinary medicine and food animal production. " 01/01/2021 - "In order to overcome MRSA infection, we synthesized compound A, a lincomycin derivative, and evaluated the biological properties. " 01/01/1993 - "[The clinical use of lincomycin in treating anaerobic infection in patients with surgical abdomen]."
2.	Dysentery 07/01/1978 - "All concentrations of lincomycin were effective for the treatment of swine dysentery by oral or by contact exposure. " 10/01/1979 - "Lincomycin levels for treatment of swine dysentery." 06/01/1976 - "Effect of lincomycin on swine dysentery." 02/01/1981 - "Also, these pigs treated with the larger lincomycin dose had better treatment responses tha did the pigs treated wih the smaller dose of lincomycin, 4.4 mg/kg, as evidenced by dysentery, fecal consistency, physically active and intermediately active pig days, body weight gain, and feed intake." 01/01/1974 - " lincomycin-spectinomycin water medication was effective for the treatment of swine dysentery. "
3.	Weight Gain 09/28/2023 - "Combined dietary supplementation with SB and lincomycin (T4 and T5) significantly enhanced body weights, weight gains, feed conversion ratio, and profitability index. " 10/01/2001 - "Based on the results of clinical observations (respiratory signs, rectal temperature, body weight gain, and feed conversion efficiency), macroscopic and histologic lesions of the lungs, and microbiologic findings, the best results were obtained by treatment of pigs with Econor + chlortetracycline, followed by Tetramutin, Pulmotil, Cyfac, and lincomycin + chlortetracycline." 12/08/1984 - "A field trial was carried out on clinically affected pigs, using tiamulin at 10 mg and 15 mg/kg bodyweight given by injection for three consecutive days, by comparing their weight gains and reduction in lameness scores during a seven day trial period (days 0 to 7) with those of negative untreated controls and positive controls injected with lincomycin at 10 mg/kg bodyweight for three days. " 06/01/1982 - "Pigs on the chlortetracycline-sulfamethazine-penicillin diet on the average tended to grow at a faster rate, attained a higher percentage weight gain, and weighed slightly more than pigs on either the lincomycin sulfate or no antibiotic diets. " 02/01/1987 - "Avoparcin, bacitracin methylenedisalisylic acid, efrotomycin, lincomycin, penicillin G procaine, and virginiamycin improved rate of weight gain and feed conversion of chicks and decreased cholyltaurine hydrolase activity in ileal homogenates relative to those of nonmedicated control birds. "
4.	Enteritis 11/01/1977 - "Birds receiving lincomycin at a concentration of 2 g./ton, or higher, showed a significant reduction in mortality from necrotic enteritis when compared to birds in coccidiostat-control pens not receiving lincomycin medication. " 11/01/1977 - "Efficacy of lincomycin feed medication for the control of necrotic enteritis in broiler-type chickens." 01/01/2023 - "Only two water-soluble administrations were recorded during the entire study period, both involving lincomycin to pullet flocks for the treatment of necrotic enteritis. " 11/01/1977 - "In each trial, various concentrations of lincomycin in feed were evaluated for effectiveness in controlling necrotic enteritis. " 04/01/1983 - "Lincomycin dose response for treatment of necrotic enteritis in broilers."
5.	Mastitis 01/01/1989 - "Lincomycin is very useful for treating dairy herds with galt mastitis." 01/01/1989 - "Lincomycin has a good influence on mastitis caused by gram positive bacteria especially streptococci and staphylococci. " 01/01/1989 - "[Lincomycin therapy of streptococcal and staphylococcal mastitis in cattle]." 07/01/2004 - "This work describes a novel plasmid encoding resistance to lincomycin in a staphylococcal isolate associated with mastitis infection from dairy cows. " 03/01/2010 - "From December 2005 to August 2007, a total of 157 clinical mastitis cases on 10 farms in northern Germany were enrolled in the study and randomly assigned (blocked by parity and body temperature) to one of two treatment groups (intrammammary lincomycin/neomycin 1.5-d (ALK) or 5-d (ALL)). "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Clindamycin (Cleocin)
3.	Spectinomycin (Spectinomycin Hydrochloride)
4.	Chlortetracycline (Aureomycin)
5.	Penicillins (Penicillin)
6.	Gentamicins (Gentamicin)
7.	Virginiamycin
8.	Lincomycin (Lincocin)
9.	Ampicillin (Omnipen)
10.	Drinking Water

Related Therapies and Procedures

1.	Therapeutics
2.	Absorbable Gelatin Sponge
3.	Retreatment
4.	Ovariectomy (Oophorectomy)
5.	Aftercare (After-Treatment)