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Leukocyte Disorders

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Disordered formation of various types of leukocytes or an abnormal accumulation or deficiency of these cells.

Also Known As:

Disorder, Leukocyte; Disorders, Leukocyte; Leukocyte Disorder

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases
- Hematologic Diseases: 1962
  - Leukocyte Disorders: 9

Related Diseases

1.	Infection
2.	Myocardial Infarction
3.	Polycystic Kidney Diseases (Polycystic Kidney Disease)
4.	Heart Failure
5.	Glaucoma

Experts

1.	Lek, Hwee San: 1 article (01/2014)
2.	Morrison, Vicky L: 1 article (01/2014)
3.	Fagerholm, Susanna C: 1 article (01/2014)
4.	Feng, Xing: 1 article (12/2013)
5.	Yu, Lun: 1 article (12/2013)
6.	Miao, Po: 1 article (12/2013)
7.	Sun, Bin: 1 article (12/2013)
8.	Melzig, M F: 1 article (01/2012)
9.	Alasbahi, R H: 1 article (01/2012)
10.	Sabnis, Himalee: 1 article (06/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Leukocyte Disorders:

1.	Acute malariaIBA 01/01/2012 - "thyroid autoimmune disorders, leukocyte signal transduction defect in depression, acute malaria infection, secretory dysfunction in inflammatory diseases) as well as its possibly beneficial role for curing diseases such as the regulation of coronary microvascular NO production after heart failure, the attenuation of the development or progression of fibrosis in the heart and lungs, the augmentation of myo-protective effects of ischemic preconditioning especially in the failing hearts after myocardial infarction, the stimulation of the regeneration of injured retinal ganglion cells, the curing of glaucoma and inflammatory diseases, the reducing of cyst formation early in the polycystic kidney disease, and the management of autoimmune disorders by enhancing Fas-mediated apoptosis. "
2.	Integrin beta3 (GPIIIa)IBA 01/01/2014 - "Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. "
3.	Losartan (Cozaar)FDA LinkGeneric 03/01/2000 - "Conversely, AT1 receptor inhibition with losartan proved to be ineffective at attenuating postischemic microcirculatory disorders (leukocyte-endothelial interactions, microvascular perfusion failure) and aggravated cellular injury. "
4.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/01/1992 - "Levels of serum granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with various leukocyte disorders were estimated by enzyme-linked immunosorbent assay (ELISA). "
5.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/01/1992 - "Levels of serum granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with various leukocyte disorders were estimated by enzyme-linked immunosorbent assay (ELISA). "
6.	IntegrinsIBA 06/10/2010 - "In the disorder leukocyte adhesion deficiency III (LAD-III), integrins on platelets and leukocytes are expressed but fail to function and this leads to severe bleeding and infections at an early age. "
7.	Superoxides (Superoxide)IBA 07/01/2001 - "A novel, multifaceted leukocyte disorder-distinguished by defects in shape change, chemotaxis, ingestion, degranulation, superoxide anion production, and bactericidal activity-was established secondary to a defect in Rac2."
8.	Retinaldehyde (Retinal)IBA 11/01/1988 - "Retinal blood velocity in patients with leukocyte disorders."
9.	Proteins (Proteins, Gene)IBA 06/01/1989 - "A rare disorder, leukocyte adhesion deficiency, has provided a model for establishing the relationship between the several distinct alpha subunits and the shared common beta subunit of leukocyte adhesion proteins. "
10.	C-Reactive ProteinIBA 12/01/2013 - "The univariate analysis showed that the prognosis of NEC was related to the factors such as sepsis, congenital heart disease, scleredema, peritonitis, metabolic acidosis, hyponatremia, leukocyte disorder, thrombocytopenia, elevated C-reactive protein, and severe abdominal X-ray abnormalities (P<0.05), and the further logistic regression analysis revealed that congenital heart disease, scleredema, and metabolic acidosis were main risk factors for the clinical outcome of NEC (P<0.05). "