Radiation-Induced Leukemia (Leukemia, Radiation Induced)

Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.

Also Known As:

Leukemia, Radiation Induced; Leukemia, Radiation-Induced; Leukemias, Radiation-Induced; Radiation Induced Leukemia; Radiation-Induced Leukemias

Networked: 31 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 1324753
- Radiation-Induced Neoplasms: 162
  - Radiation-Induced Leukemia: 31
- Neoplasms by Histologic Type: 2
  - Leukemia: 58722
    - Radiation-Induced Leukemia: 31
Hemic and Lymphatic Diseases: 6
- Hematologic Diseases: 3366
  - Leukemia: 58722
    - Radiation-Induced Leukemia: 31
Wounds and Injuries: 176426
- Radiation Injuries: 2684
  - Radiation-Induced Leukemia: 31
Physical Phenomena
- Radiation
  - Radiation Exposure
    - Radiation Injuries: 2684
      - Radiation-Induced Leukemia: 31

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Leukemia
3.	Neoplasms (Cancer)
4.	Lymphoma (Lymphomas)
5.	T-Cell Lymphoma (Lymphoma, T Cell)

Experts

1.	Akkoyunlu, Ramis Ufuk: 1 article (03/2016)
2.	Gluzman, Daniil F: 1 article (03/2016)
3.	Koval, Stella V: 1 article (03/2016)
4.	Savlı, Hakan: 1 article (03/2016)
5.	Sklyarenko, Lilia M: 1 article (03/2016)
6.	Sünnetçi, Deniz: 1 article (03/2016)
7.	Zavelevich, Michael P: 1 article (03/2016)
8.	Çine, Naci: 1 article (03/2016)
9.	Bacher, Jeffery W: 1 article (09/2014)
10.	Bielefeldt-Ohmann, Helle: 1 article (09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radiation-Induced Leukemia:

1.	tetrachlorodecaoxide (Oxoferin)IBA 11/01/1994 - "The effect of tetrachlorodecaoxide (TCDO) treatment after total-body irradiation (TBI) with gamma-rays (single dose, about LD 50) on the development of radiation-induced leukemia was tested in rats. " 08/01/1994 - "In particular, there was a highly significant prevention of radiation-induced leukemia [P (one-sided) < 0.001] by TCDO, and a significantly reduced incidence of malignant epithelial tumors [P (one-sided) < 0.05]. "
2.	AntigensIBA 01/01/1988 - "Early studies of the resistance and susceptibility of mouse strains to radiation-induced leukemia virus have demonstrated the important role of altered histocompatibility (H-2) antigen expression in the effectiveness of the immune response of the host to virus-infected and transformed cells. " 12/01/1979 - "Rabbit antiserum against mouse brain tissue (anti-brain-associated T cell antigen, anti-BAT) was capable of killing splenic natural killer (NK) cells of CBA/J, BALB/c, C 57 Bl/6J, C 3 H/He and nude mice, which were detected with Molony virus-induced lymphoma (YAC-1) and radiation-induced leukemia (RL male 1) cells as targets. " 04/01/1979 - "A role for elevated H-2 antigen expression in resistance to neoplasia caused by radiation-induced leukemia virus. " 12/01/1999 - "The unique antigen peptide pRL1 on BALB/c radiation-induced leukemia RL(male symbol)1 cells is derived from the normally untranslated 5' region of the mouse c-akt gene. "
3.	Biomarkers (Surrogate Marker)IBA 03/05/2016 - "These results could be accepted as specific gene traces to radiation-induced leukemia or as potential candidates for new diagnostic biomarker studies. "
4.	Isoantigens (Alloantigen)IBA 01/01/1967 - "[Study on the isoantigens of 2 radiation-induced leukemias]."
5.	Radioisotopes (Radionuclides)IBA 08/01/1988 - "Although there is some uncertainty about the releases from the plant and concentrations of radionuclides in environmental materials in the Sellafield area, particularly for the early years of its operation, the possibility that the doses calculated and the risk coefficients used for radiation-induced leukemia could be so substantially wrong is very unlikely. " 11/01/2002 - "This complex of tags is typical for induced leukemias, and in a combination with definition of a level of stable aberrations in peripheral blood lymphocytes, can be utilised for abjection of radiation-induced leukemias from common mass of cases detected in regions, polluted by radionuclides. "
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/01/1984 - "In a previous paper we described the induction by x-irradiation or radiation-induced leukemia virus-inoculation of two classes of lymphoid T-cell neoplasms: The first class, designated T-cell lymphoblastoma (TCLB), consists of growth-factor-dependent eudiploid cells that home to the spleen and give rise to splenic tumors on injection into syngeneic mice; the second class, designated T-cell lymphoma (TCL), consists of growth-factor-independent aneuploid or pseudodiploid cells that give rise to local tumors at the site of subcutaneous injection. "
7.	Peanut AgglutininIBA 04/01/1980 - "Preleukemic bone marrow and spleen cells of irradiated C57BL/6 mice that were inoculated with the radiation-induced leukemia virus variant D-RadLV differ from autonomous end-stage leukemia cells in the expression of the receptor for peanut agglutinin. "
8.	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 10/01/1993 - "In the mice with radiation-induced leukemia, those receiving G-CSF had a mean survival time of 357 days, whereas those not receiving the factor survived for 349 days. "
9.	Urethane (Ethyl Carbamate)IBA 01/01/1973 - "Radiation-induced leukemia in rats: synergistic effect of urethan."
10.	Protons (Proton)IBA 10/09/2023 - "In view of healthy tissue damage and the increased risk of secondary cancers, we investigated DNA damage induction and repair of radiosensitive hematopoietic stem and progenitor cells (HSPCs) exposed to therapeutic proton and photon irradiation due to their role in radiation-induced leukemia. "

Therapies and Procedures

1.	Nuclear Power Plants 05/01/2012 - "The second large cohort that would allow to study radiation-induced leukemia is comprised of individuals who were exposed due to the accident of the Chernobyl nuclear power plant in 1986. "
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/01/1994 - "The intensity of graft-versus-leukemia (GVL) effect was studied using several radiation-induced leukemia cell lines (designated 8027, 8313, 9107, 7929) in MHC-compatible and -incompatible allogeneic bone marrow transplantation (BMT) of leukemia-bearing C3H mice. " 02/01/1994 - "Graft-versus-leukemia effect in allogeneic bone marrow transplantation in mice against several radiation-induced leukemias." 11/01/1991 - "Manifestation of graft-versus-leukemia (GVL) effect in MHC-compatible and -incompatible, allogeneic bone marrow transplantation and the roles of T cell subsets contaminated in the donor bone marrow were studied using radiation-induced leukemia-bearing C3H mice maintained under specific-pathogen-free (SPF) condition. " 11/01/1991 - "Graft-versus-leukemia effect in MHC-compatible and -incompatible allogeneic bone marrow transplantation of radiation-induced, leukemia-bearing mice."
3.	Radiotherapy 12/20/2006 - "Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks." 01/01/2002 - "Epidemiological data indicate a small but significant risk of radiation-induced leukemia after radiotherapy which might be related to the high mean bone marrow dose associated with radiotherapy of prostate cancer. "
4.	Subcutaneous Injections 03/01/1984 - "In a previous paper we described the induction by x-irradiation or radiation-induced leukemia virus-inoculation of two classes of lymphoid T-cell neoplasms: The first class, designated T-cell lymphoblastoma (TCLB), consists of growth-factor-dependent eudiploid cells that home to the spleen and give rise to splenic tumors on injection into syngeneic mice; the second class, designated T-cell lymphoma (TCL), consists of growth-factor-independent aneuploid or pseudodiploid cells that give rise to local tumors at the site of subcutaneous injection. "