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Acute Monocytic Leukemia (Acute Monoblastic Leukemia)

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An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.

Also Known As:

Acute Monoblastic Leukemia; Monocytic Leukemia, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Schilling Type; Acute Monoblastic Leukemias; Acute Monocytic Leukemias; Leukemia, Acute Monoblastic; Leukemia, Acute Monocytic; Leukemia, Schilling-Type Myeloid; Leukemias, Acute Monoblastic; Leukemias, Acute Monocytic; Monoblastic Leukemias, Acute; Monocytic Leukemias, Acute; Myeloid Leukemia, Schilling Type; Schilling-Type Myeloid Leukemia; Leukemia, Monoblastic, Acute; Leukemia, Myeloid, Acute, M5; Leukemia, Myeloid, Schilling-Type; Monoblastic Leukemia, Acute; Myeloid Leukemia, Acute, M5; Myeloid Leukemia, Schilling-Type

Networked: 363 relevant articles (17 outcomes, 36 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Leukemia: 41436
    - Myeloid Leukemia: 2978
      - Acute Myeloid Leukemia: 14185
        Acute Monocytic Leukemia: 363

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
2.	Acute Myelomonocytic Leukemia
3.	Neuroblastoma
4.	Respiratory Insufficiency (Respiratory Failure)
5.	Quadriplegia (Locked In Syndrome)

Experts

1.	Zhang, Wang-Gang: 5 articles (02/2013 - 06/2008)
2.	Xie, Hongxiang: 4 articles (08/2014 - 10/2012)
3.	Zhou, Hong: 4 articles (08/2014 - 10/2012)
4.	Zhang, Peng-Yu: 4 articles (02/2013 - 02/2009)
5.	Wang, Yingchao: 3 articles (09/2015 - 01/2012)
6.	Sheng, Guangyao: 3 articles (09/2015 - 01/2012)
7.	Yan, Jinchuan: 3 articles (08/2014 - 10/2012)
8.	Wang, Ting: 3 articles (04/2014 - 10/2012)
9.	Chen, Yin-Xia: 3 articles (02/2013 - 10/2009)
10.	He, Ai-Li: 3 articles (02/2013 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Monocytic Leukemia:

1.	trisomy Chromosome 8IBA 07/07/2013 - "[Spontaneous remission of bone marrow aplasia associated with chromosome 8 trisomy, with subsequent evolution to acute monoblastic leukemia and recurrence of the clonal abnormality]." 01/20/2007 - "Hematologic and cytogenetic spontaneous remission in acute monocytic leukemia (FAB M5b) with trisomy 8." 01/01/2010 - "A 57-year-old man was diagnosed as having acute monoblastic leukemia with t(9;11)(p22;q23) and trisomy 8. Ten months after achieving complete response (CR) with chemotherapy, masses developed in his left forearm and in the back of his thigh, preceded by enigmatic peripheral neurological symptoms. " 09/01/2001 - "Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia." 05/01/1994 - "This was most common in acute monocytic leukemia (15 of 18, 83%) and in patients with the cytogenetic abnormalities t(8;21) (seven of 13, 54%) and trisomy 8 (nine of 22, 41%). "
2.	Small Interfering RNA (siRNA)IBA 04/01/2008 - "This study was aimed to investigate the effect of small interfering RNA (siRNA) on the expression of mll-af9 oncogene and the proliferation of human acute monocytic leukemia cell line THP-1. " 08/01/2013 - "It is concluded that the shRNA targeting DOT1L can effectively inhibit the proliferation of acute monocytic leukemia cell line THP-1." 04/01/2008 - "It is concluded that the mll-af9-targeted siRNA can effectively inhibit the proliferation of human acute monocytic leukemia cell line THP-1." 08/01/2007 - "The aim of the present study was to investigate the efficacy of suppression of FLT3 induced by small hairpin interfering RNA (shRNA) on myeloproliferation and apoptosis in an acute monocytic leukemia (AMOL) cell line THP-1. " 04/01/2008 - "Then the obtained siRNA was transfected into cultured human acute monocytic leukemia cell line THP-1 by lipofectamine. "
3.	RNA (Ribonucleic Acid)IBA 08/01/2007 - "The aim of the present study was to investigate the efficacy of suppression of FLT3 induced by small hairpin interfering RNA (shRNA) on myeloproliferation and apoptosis in an acute monocytic leukemia (AMOL) cell line THP-1. " 09/01/2012 - "Significant elevations in Klk6 RNA were also induced in splenocytes stimulated with viral capsid proteins in vitro and in activated human acute monocytic leukemia cells. " 01/01/2001 - "In order to determine the full coding sequence of this novel mRNA, we isolated seven cDNA clones from a human cDNA library transcribed from RNA of the acute monocytic leukemia cell line THP1 by colony hybridization. "
4.	bryostatin 5IBA 10/15/2013 - "These novel findings provide mechanistic insight into the induction of apoptosis by bryostatin 5 and might facilitate the development of clinical strategies to enhance the therapeutic efficacy of treatments for acute monocytic leukemia. " 10/15/2013 - "In the current study, we examined the effects of bryostatin 5 on acute monocytic leukemia cells in vitro and in vivo. " 10/15/2013 - "We also explored the mechanisms and pathways underlying the increase in apoptosis induced by bryostatin 5. Bryostatin 5 inhibited the growth of primary acute monocytic leukemia cells and U937 cells in a dose- and time-dependent manners. " 10/15/2013 - "Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases."
5.	DNA (Deoxyribonucleic Acid)IBA 01/01/1990 - "We studied a novel restriction fragment length polymorphism (RFLP) of the proto-oncogenes ETS-1 that we detected in a patient with an acute monocytic leukemia by the presence of two, 3.7 and 10 kb, Xbal fragments on Southern blots of DNA from blast cells and remission blood samples. " 04/01/2011 - "Our work suggests a contribution of aberrant DNA methyltransferase activity to the pathogenesis of acute monocytic leukemia and provides a useful new biomarker for relevant cases." 04/01/2011 - "Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia." 01/01/1986 - "The chromosome localization of a 5.4 kb DNA genomic probe of proto-oncogene c-ets 1 has been analysed in an acute monocytic leukemia with t (1; 11) (q21; q23) translocation. " 05/01/2005 - "We have applied the method of serologic analysis of recombinant cDNA expression library (SEREX) on acute monocytic leukemia (FAB M5), followed by DNA sequencing and analyzing of positive clones. "
6.	IronIBA 05/01/1999 - "sennetsu, but not HGE agent, in the acute monocytic leukemia cell line THP-1 almost completely inhibited by treatment with deferoxamine, a cell-permeable iron chelator. " 05/01/2011 - "Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia." 05/01/2011 - "A patient with chemotherapy-resistant acute monocytic leukemia who achieved complete remission (CR) after iron chelation therapy (ICT) with deferasirox is reported for the first time. " 07/15/1980 - "The iron content of acute monocytic leukemia cell ferritin was extremely low, and this ferritin migrated slightly faster than normal adult liver ferritin on immunoelectrophoresis and polyacrylamide gel disc electrophoresis. "
7.	Acute erythroleukemiaIBA 11/01/1981 - "Acute monocytic leukemia (M5) and acute erythroleukemia (M6) accounted for 12% of the cases accessioned and had the worst median survival with no patients surviving 2 years. " 06/01/1986 - "Among 10 cases (3, acute myelocytic leukemia; 4, acute myelomonocytic leukemia; 2, acute monocytic leukemia; and one, acute erythroleukemia) in which an evaluation was possible, 5 cases (3, acute myelomonocytic leukemia; and 2, acute monocytic leukemia) obtained complete remission (CR). " 07/01/2006 - "The most common types of acute myeloid leukemia arising in this setting are acute myeloid leukemia with maturation, and lesser numbers of acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroleukemia, or acute megakaryocytic leukemia. "
8.	Macrophage Colony-Stimulating FactorIBA 01/01/1995 - "A 93-year-old patient with hypoplastic acute monocytic leukemia (AMoL) achieved a complete remission after macrophage colony-stimulating factor (M-CSF) therapy. " 01/01/1995 - "Successful treatment of a 93-year-old patient with hypoplastic acute monocytic leukemia using macrophage colony-stimulating factor." 06/01/2000 - "In cases of acute monocytic leukemia, M-CSF showed a higher stimulating index than that observed for non-monocytic leukemia. "
9.	deferasirox FDA Link 05/01/2011 - "Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia." 05/01/2011 - "A patient with chemotherapy-resistant acute monocytic leukemia who achieved complete remission (CR) after iron chelation therapy (ICT) with deferasirox is reported for the first time. "
10.	DCMP protocolIBA 06/01/1989 - "A complete remission (CR) was obtained by DCMP regimen, but he relapsed as acute monocytic leukemia (M 5 b in FAB classification) and died 5 months after diagnosis. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/2009 - "Of the 6 patients with MDS, one achieved partial remission, four no remission, and one transformed into acute monocytic leukemia, then refused chemotherapy and was lost follow-up. " 01/01/2015 - "Therefore, manipulation of NO production could be viewed as a potential strategy to increase efficacy of chemotherapy in acute monocytic leukemia. " 05/01/2015 - "We have used a hypomethylating agent instead of conventional chemotherapy to induce remission in a young Jehovah's Witness with acute monocytic leukemia to avoid severe myelosuppression and blood product support. " 07/15/2006 - "After chemotherapy, this patient developed an acute monoblastic leukemia (M5b) with retention of the t(11;16)(q23;p13.3), indicating that this is a lineage switch of the original leukemic clone. " 05/15/2003 - "Leukemic pulmonary infiltration as the first manifestation of acute monocytic leukemia should be recognized, and intensive management should be provided in anticipation of the respiratory function deterioration seen consistently after chemotherapy initiation."
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 07/01/1983 - "[Case of acute monocytic leukemia brought to the second remission by allogeneic bone marrow transplantation but eventually developing subcutaneous blastoma]." 01/01/1999 - "IL-2/LAK therapy for refractory acute monoblastic leukemia relapsing after unrelated allogeneic bone marrow transplantation." 09/01/1984 - "The clinical course, serial pulmonary function studies, lung histopathologic findings, and treatment in two patients after bone marrow transplantation for acute monoblastic leukemia or aplastic anemia are presented. " 01/01/1991 - "Autologous bone marrow transplantation in secondary acute monoblastic leukemia following Hodgkin's disease." 01/01/1986 - "Bone marrow transplantation for acute monocytic leukemia following the treatment of Hodgkin's disease."
3.	Transplantation (Transplant Recipients) 01/01/2012 - "Eight weeks after transplantation, all the recipient mice had developed acute monoblastic leukemia (the M5 phenotype in French-American-British classification). " 01/01/2008 - "Donor cell-derived acute monoblastic leukemia involving MLL gene translocation in an adult patient who received umbilical cord blood transplantation." 10/01/2001 - "We report a successful transplantation with CD34+ blood cells selected from a 2-loci HLA-mismatched mother to a child with acute monocytic leukemia after engraftment failure of the primary CBT. " 04/01/2005 - "[Long-term remission in an acute monoblastic leukemia patient with down syndrome after cord blood transplantation]." 01/01/2011 - "The paper describes a case of evolving acute myeloid leukemia of a graft in a patient with resistant acute monoblastic leukemia after related allogeneic peripheral BSC transplantation. "
4.	Chelation Therapy (Therapy, Chelation) 05/01/2011 - "Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia." 05/01/2011 - "A patient with chemotherapy-resistant acute monocytic leukemia who achieved complete remission (CR) after iron chelation therapy (ICT) with deferasirox is reported for the first time. "
5.	Liver Transplantation 12/28/2005 - "To study the clinical features and molecular genetics of acute monocytic leukemia (AML) after orthotopic liver transplantation and significance thereof. " 12/28/2005 - "[Acute monocytic leukemia after orthotopic liver transplantation: clinical features, molecular genetics, and significance thereof]." 07/01/2006 - "A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. " 07/01/2006 - "Myelodysplastic syndrome with transformation to acute monocytic leukemia with FLT3-ITD mutation following orthotopic liver transplantation."