Mast-Cell Leukemia (Leukemia, Mast Cell)

A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival.

Also Known As:

Networked: 70 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
2.	Mastocytosis (Mast-Cell Disease)
3.	Myeloid Leukemia (Leukemia, Myelocytic)
4.	Testicular Neoplasms (Testicular Cancer)
5.	Systemic Mastocytosis

Experts

1.	Valent, Peter: 6 articles (10/2013 - 01/2002)
2.	Pardanani, Animesh: 5 articles (03/2015 - 01/2002)
3.	Sperr, Wolfgang R: 4 articles (10/2007 - 01/2002)
4.	Horny, Hans-Peter: 3 articles (10/2013 - 01/2002)
5.	Neckers, Len: 3 articles (05/2008 - 02/2004)
6.	Pan, Jingxuan: 2 articles (05/2014 - 01/2010)
7.	Reiter, Andreas: 2 articles (10/2013 - 09/2013)
8.	Sotlar, Karl: 2 articles (10/2013 - 10/2005)
9.	Kajiguchi, Tomohiro: 2 articles (05/2008 - 10/2005)
10.	Lechner, Klaus: 2 articles (03/2004 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mast-Cell Leukemia:

1.	masitinibIBA 07/01/2012 - "It also indicates that masitinib may be safe and effective for the treatment for some mast cell leukemia." 07/01/2012 - "Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor."
2.	17-(allylamino)-17-demethoxygeldanamycin (17AAG)IBA 02/01/2004 - "These data provide compelling evidence that 17-AAG may be effective in the treatment of c-kit-related diseases including mastocytosis, GISTs, mast cell leukemia, subtypes of acute myelogenous leukemia, and testicular cancer."
3.	Immunoglobulin E (IgE)IBA 06/01/2012 - "Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor β chain and KIT V654A." 03/01/2014 - "The increased avidity for IgE made HBI a potent inhibitor of mast cell degranulation in the rat basophilic leukemia mast cell model, in the passive cutaneous anaphylaxis mouse model of allergy, and in mice sensitized to the model allergen. " 12/01/2006 - "A rat basophilic leukemia mast cell line (RBL-2H3) was activated via IgE/anti-IgE. " 04/30/2014 - "In the present study, the effects of ARE and its active compounds, quercetin and kaempferol, on IgE-mediated rat basophilic leukemia mast cell activation and passive cutaneous anaphylaxis (PCA) were investigated. "
4.	Chemokine CCL5IBA 03/01/2002 - "RANTES and CCR1 were expressed on T cells and mast cells in OLP, while OLP lesional T cell supernatants stimulated CCR1 mRNA expression in a human leukemia mast cell line (HMC-1). " 05/13/1994 - "In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interleukin-8. "
5.	Macrophage Inflammatory ProteinsIBA 05/13/1994 - "In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interleukin-8. "
6.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 05/13/1994 - "In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interleukin-8. "
7.	ChemokinesIBA 05/13/1994 - "In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interleukin-8. "
8.	Interleukin-8 (Interleukin 8)IBA 05/13/1994 - "In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interleukin-8. "
9.	CytokinesIBA 07/01/1995 - "In vitro studies have implicated both cytokines in the autocrine growth of human myeloid or murine mast cell leukemias. "
10.	QuercetinIBA 04/30/2014 - "In the present study, the effects of ARE and its active compounds, quercetin and kaempferol, on IgE-mediated rat basophilic leukemia mast cell activation and passive cutaneous anaphylaxis (PCA) were investigated. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 07/01/1971 - "Chemotherapy in reticulum-cell sarcoma in five dogs and a cat and in mast-cell leukemia in a cat." 07/01/2003 - "We report a case of acute myeloid leukemia (AML) with t(8;21) and mast cell leukemia (MCL) in which the mastocytosis persisted after standard chemotherapy and allogeneic stem cell transplantation, although the myeloid leukemia achieved molecular complete remission soon after induction chemotherapy. " 07/01/2004 - "Whereas indolent forms of systemic mastocytosis are mainly treated with antihistamines, glucocorticosteroids and PUVA therapy, the more aggressive forms, including mast cell leukemia, often require cytostatic chemotherapy. "
2.	Stem Cell Transplantation 07/01/2003 - "Rapid engraftment of mast cells of donor origin in a case of acute myeloid leukemia with mast cell leukemia after allogeneic stem cell transplantation." 07/01/2003 - "We report a case of acute myeloid leukemia (AML) with t(8;21) and mast cell leukemia (MCL) in which the mastocytosis persisted after standard chemotherapy and allogeneic stem cell transplantation, although the myeloid leukemia achieved molecular complete remission soon after induction chemotherapy. "
3.	Hematopoietic Stem Cell Transplantation 03/01/2013 - "After allogeneic hematopoietic stem cell transplantation (HSCT), leukemic myeloblasts were not observed; however, neoplastic metachromatic blasts strikingly proliferated during the state of bone marrow aplasia, and finally, aleukemic mast cell leukemia developed. " 03/01/2013 - "A case of systemic mastocytosis associated with acute myeloid leukemia terminating as aleukemic mast cell leukemia after allogeneic hematopoietic stem cell transplantation."
4.	Liver Transplantation 02/22/1999 - "Case 1 documents the first successful orthotopic liver transplantation in a patient with mastocytosis; case 2 depicts a potential hereditary component of mastocytosis; and case 3 documents the progression of mastocytosis with hematologic abnormality to mast cell leukemia. "
5.	PUVA Therapy 07/01/2004 - "Whereas indolent forms of systemic mastocytosis are mainly treated with antihistamines, glucocorticosteroids and PUVA therapy, the more aggressive forms, including mast cell leukemia, often require cytostatic chemotherapy. "