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Mast-Cell Leukemia (Leukemia, Mast Cell)

A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival.
Also Known As:
Leukemia, Mast Cell; Leukemia, Mast-Cell; Leukemias, Mast-Cell; Mast Cell Leukemia; Mast-Cell Leukemias
Networked: 99 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Mastocytosis
2. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
3. Systemic Mastocytosis
4. Hematologic Neoplasms (Hematological Malignancy)
5. Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)

Experts

1. Valent, Peter: 9 articles (01/2021 - 01/2002)
2. Horny, Hans-Peter: 6 articles (01/2020 - 01/2002)
3. Reiter, Andreas: 4 articles (01/2021 - 09/2013)
4. Sotlar, Karl: 4 articles (06/2016 - 10/2005)
5. Sperr, Wolfgang R: 4 articles (10/2007 - 01/2002)
6. Pardanani, Animesh: 3 articles (01/2022 - 01/2002)
7. Tefferi, Ayalew: 3 articles (01/2022 - 01/2002)
8. Valent, P: 3 articles (01/2018 - 05/2001)
9. Akin, Cem: 3 articles (06/2016 - 08/2003)
10. Neckers, Len: 3 articles (05/2008 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mast-Cell Leukemia:
1. midostaurinIBA
2. Tyrosine Kinase InhibitorsIBA
3. masitinibIBA
4. tanespimycin (17AAG)IBA
5. avapritinibIBA
6. CytokinesIBA
7. Immunoglobulin E (IgE)IBA
8. Chemokine CCL5IBA
9. Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA
10. Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Induction Chemotherapy
3. Stem Cell Transplantation
4. Therapeutics
5. Hematopoietic Stem Cell Transplantation