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Leucyl Aminopeptidase (Peptidase S)

A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Also Known As:
Peptidase S; Leucine Aminopeptidase; L-Leucylnaphthylamidase; Methoxyleucine Aminopeptidase; Zinc-Manganese-Leucine Aminopeptidase; Aminopeptidase, Cytosol; Aminopeptidase, Leucine; Aminopeptidase, Leucyl; Aminopeptidase, Methoxyleucine; Aminopeptidase, Zinc-Manganese-Leucine; Zinc Manganese Leucine Aminopeptidase; Cytosol Aminopeptidase
Networked: 356 relevant articles (2 outcomes, 26 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Walling, Linda L: 6 articles (06/2014 - 03/2002)
2. Fang, Chunyan: 5 articles (10/2020 - 12/2015)
3. Wang, Xuejian: 4 articles (10/2020 - 12/2015)
4. Wang, Sensen: 3 articles (10/2020 - 01/2019)
5. Yang, Hanlin: 3 articles (01/2020 - 01/2019)
6. Zhao, Xin: 3 articles (01/2020 - 01/2019)
7. Chen, Zuxing: 3 articles (11/2019 - 11/2017)
8. Lu, Cuifen: 3 articles (11/2019 - 11/2017)
9. Nie, Junqi: 3 articles (11/2019 - 11/2017)
10. Ren, Jun: 3 articles (11/2019 - 11/2017)

Related Diseases

1. Infections
2. Fascioliasis
3. Neoplasms (Cancer)
4. Urologic Diseases (Urinary Tract Disease)
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. Peptide Hydrolases (Proteases)
2. Cathepsin L
3. Enzymes
4. Alkaline Phosphatase
5. Acid Phosphatase
6. Isoenzymes
7. Oxidoreductases (Dehydrogenase)
8. beta 2-Microglobulin (beta 2 Microglobulin)
9. Hexosaminidases (Hexosaminidase)
10. Transferases

Related Therapies and Procedures

1. Transplantation
2. Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3. Drug Therapy (Chemotherapy)
4. Precision Medicine
5. Therapeutics