Leucyl Aminopeptidase (S, Peptidase)

A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.

Also Known As:

Networked: 288 relevant articles (2 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Walling, Linda L: 6 articles (06/2014 - 03/2002)
2.	Dalton, John P: 3 articles (01/2010 - 01/2006)
3.	Trenholme, Katharine R: 3 articles (01/2010 - 01/2006)
4.	Stack, Colin M: 3 articles (01/2010 - 01/2006)
5.	Gardiner, Donald L: 3 articles (01/2010 - 01/2006)
6.	Hattori, Akira: 3 articles (03/2006 - 08/2003)
7.	Tsujimoto, Masafumi: 3 articles (03/2006 - 08/2003)
8.	Kikkawa, Fumitaka: 3 articles (01/2005 - 08/2003)
9.	Ino, Kazuhiko: 3 articles (01/2005 - 08/2003)
10.	Shibata, Kiyosumi: 3 articles (01/2005 - 08/2003)

Related Diseases

1.	Infection 11/08/2011 - "The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep." 01/01/1982 - "[Significance of the study of leucine aminopeptidase activity of the blood serum in patients with suppurative surgical infections]." 04/01/2011 - "To investigate the antibody response to leucine aminopeptidase in the different stages of Schistosoma japonicum infection. " 04/01/2011 - "[Antibody responses to leucine aminopeptidase in Schistosoma japonicum infection]." 02/01/2001 - "Tomato plants constitutively express a neutral leucine aminopeptidase (LAP-N) and an acidic LAP (LAP-A) during floral development and in leaves in response to insect infestation, wounding, and Pseudomonas syringae pv. tomato infection. "
2.	Fascioliasis 04/01/1999 - "Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep." 04/01/1999 - "The potential of different parasite proteinases for use as vaccine candidates against fascioliasis in sheep was studied by vaccinating animals with the cathepsin L proteinases CL1 and CL2 and with leucine aminopeptidase (LAP) purified from adult flukes. "
3.	Neoplasms (Cancer) 06/25/1964 - "[STUDIES ON THE CAUSE OF INCREASED LEUCINE AMINOPEPTIDASE ACTIVITY IN THE URINE DURING TUMOR IRRADIATION]." 11/01/1985 - "Tumor cell reorganization was observed in the absence of formation of full junctional complexes or normally polarized membrane domains, although leucine aminopeptidase appeared to be excluded from regions of tumor cell surfaces that were in direct contact with BM. " 11/01/1985 - "Intermediate to these is line 168, which is nonmetastatic from the subcutaneous site but capable of colonizing the lung with an efficiency similar to 66 when injected IV. Tumor-associated macrophages (TAM) from lines 66, D2A1, and D2F2 contained the greatest amounts of leucine aminopeptidase (LAP) and those from line 67 the least, with TAM from 168 being intermediate. " 01/01/1985 - "Leucine aminopeptidase of neutrophils and lymphocytes in patients with cancer." 04/30/1967 - "[Biochemical evaluation of the leucine aminopeptidase content of malignant neoplasms of the female genital system]."
4.	Urologic Diseases (Urinary Tract Disease) 10/01/1969 - "[Studies on leucine aminopeptidase (LAP) in urological diseases. " 12/01/1968 - "[Studies on leucine aminopeptidase (LAP) in urological diseases. "
5.	Jaundice 03/01/1968 - "[Behavior of leucine aminopeptidase in jaundice of infancy]." 03/01/1964 - "SERUM LEUCINE AMINOPEPTIDASE IN ICTERUS OF THE NEWBORN." 10/12/1963 - "Leucine aminopeptidase and 5-nucleotidase activities were often increased by malignant infiltration of the liver and primary hepatic disease even in the absence of jaundice.Serum" 09/01/1962 - "[Serum leucine aminopeptidase (LAP) in the differential diagnosis of jaundice]." 09/01/1960 - "[Leucine aminopeptidase in the differential diagnosis of jaundice]."

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Cathepsin L
3.	Alkaline Phosphatase
4.	Acid Phosphatase
5.	Enzymes
6.	Oxidoreductases
7.	Isoenzymes
8.	beta 2-Microglobulin (beta 2 Microglobulin)
9.	Hexosaminidases (Hexosaminidase)
10.	Transferases

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
4.	Ligation
5.	Brachytherapy