Lentigo (Lentiginosis)

Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).
Also Known As:
Lentiginosis; Lentiginoses; Lentigos
Networked: 144 relevant articles (6 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Melanosis (Freckles)
2. Cafe-au-Lait Spots (Spot, Cafe-au-Lait)
3. Seborrheic Keratosis
4. Erythema
5. Nevus of Ota


1. Imokawa, Genji: 5 articles (07/2013 - 04/2004)
2. Nakajima, Hiroaki: 3 articles (07/2013 - 07/2012)
3. Hachiya, Akira: 2 articles (01/2015 - 11/2006)
4. Ohuchi, Atsushi: 2 articles (01/2015 - 11/2006)
5. Kawashima, Makoto: 2 articles (07/2013 - 05/2004)
6. Wakabayashi, Yuki: 2 articles (03/2013 - 07/2012)
7. Lee, Jongsung: 2 articles (12/2011 - 06/2007)
8. Park, Deokhoon: 2 articles (12/2011 - 06/2007)
9. Tadokoro, Taketsugu: 2 articles (10/2011 - 06/2010)
10. Landthaler, Michael: 2 articles (11/2009 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lentigo:
1. CosmeticsIBA
2. Plant ExtractsIBA
3. Ascorbic Acid (Vitamin C)FDA LinkGeneric
4. Melanins (Melanin)IBA
5. glycolic acid (glycolate)IBA
6. styrene-methylmethacrylate copolymerIBA
7. Endothelin B ReceptorIBA
01/01/2015 - "Since our continuous studies using skin specimens from more than 30 subjects with ethnic skin diversity emphasized a consistent augmentation in the expression of endothelin-1 (ET-1) and its receptor (Endothelin B receptor, ET-B) in hyperpigmented lesions, including senile lentigos (SLs), the precise function of ET-1 signaling was investigated in the present study. "
05/01/2004 - "We previously reported that accentuated expression of the endothelin-1 (ET-1)/endothelin B receptor (ET(B)R) cascade is involved in the mechanism of hyperpigmentation in lentigo senilis (LS) lesions. "
04/01/2001 - "These findings suggest that an accentuation of the epidermal endothelin cascade, especially with respect to expression of endothelin and the endothelin B receptor, plays an important role in the mechanism involved in the hyperpigmentation of lentigo senilis."
04/01/2001 - "In this study, we have used immunohistochemistry and reverse transcriptase polymerase chain reaction analysis to clarify the role of the endothelin cascade, including endothelin production, processing by endothelin-converting enzyme, and expression of the endothelin B receptor, in the hyperpigmentary mechanism(s) involved in lentigo senilis. "
04/01/2001 - "Reverse transcriptase polymerase chain reaction analysis concomitantly demonstrated accentuated expression of transcripts for endothelin-1 and for the endothelin B receptor in lentigo senilis lesional skin, which was accompanied by a similar accentuated expression of tyrosinase mRNA compared with the perilesional control. "
8. Endothelin-1 (Endothelin 1)IBA
9. DNA (Deoxyribonucleic Acid)IBA
10. Endothelins (Endothelin)IBA

Therapies and Procedures

1. Solid-State Lasers
2. Lasers (Laser)
3. Cryotherapy (Therapy, Cold)
4. Dermabrasion
5. Cryosurgery