Lens Subluxation

Incomplete rupture of the zonule with the displaced lens remaining behind the pupil. In dislocation, or complete rupture, the lens is displaced forward into the anterior chamber or backward into the vitreous body. When congenital, this condition is known as ECTOPIA LENTIS.

Also Known As:

Networked: 197 relevant articles (7 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aphakia
2.	Cataract (Cataracts)
3.	Glaucoma
4.	Angle-Closure Glaucoma (Glaucoma, Angle Closure)
5.	Astigmatism

Experts

1.	Vvedenskiy, A S: 5 articles (01/2021 - 01/2020)
2.	Yusef, Yu N: 5 articles (01/2021 - 01/2020)
3.	Yusef, S N: 4 articles (01/2021 - 01/2020)
4.	Voronin, G V: 4 articles (01/2020 - 11/2012)
5.	Duma, Stefan M: 4 articles (04/2012 - 10/2005)
6.	Rastogi, Anju: 3 articles (01/2022 - 10/2018)
7.	Jiang, Yongxiang: 3 articles (11/2021 - 01/2021)
8.	Alkharki, L: 3 articles (01/2021 - 01/2020)
9.	Fokina, N D: 3 articles (01/2021 - 01/2020)
10.	Zheng, Danying: 3 articles (01/2021 - 04/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lens Subluxation:

1.	FluorocarbonsIBA 04/01/1993 - "[Liquid perfluorocarbons in surgery for lens subluxation]." 01/01/1996 - "The purpose of this study is to review the benefits of perfluorocarbon liquids in the surgical treatment of retinal detachment with posterior lens dislocation. "
2.	PhysostigmineIBA 04/01/2012 - "The aim of this study was to investigate the usefulness of a long-acting miotic (physostigmine) after phacoemulsification in preventing peripheral anterior synechiae (PAS), lens dislocation, and high postoperative intraocular pressure. "
3.	Retinaldehyde (Retinal)IBA 03/01/2015 - "Lens subluxation and retinal dysfunction in a girl with homozygous VSX2 mutation." 10/01/1986 - "There was one retinal dialysis, and one lens dislocation requiring extraction. " 01/01/2008 - "A 37-year-old woman with spontaneous lens dislocation after vitrectomy for retinal reattachment." 12/01/2016 - "The following categories of related or possibly related adverse events have been identified: acute reduction in visual acuity, ERG changes, dyschromatopsia, retinal tear or detachment, lens subluxation or phacodonesis, abnormal pupillary reflex, retinal vascular changes, and OCT ellipsoid zone alterations. " 04/01/2012 - "Injury risk varied between 4.4%-27.8% for hyphema, 0.0%-3.0% for lens dislocation, and 0.1%-3.3% for retinal damage. "
4.	Capsules (Microcapsules)IBA 01/01/2022 - "The appearance of lamellar structures indicates fragility of the lens capsule, which may, in turn, lead to capsular delamination or lens dislocation in some cases." 05/11/2018 - "Conclusion: The surgical strategy of iris hooks combined with MCTRs in the treatment of serious lens subluxation could maintain long-term stability of the capsule. " 02/01/2013 - "Anterior capsule tears occurred in 4% and 0.31% of eyes, posterior capsule tears in 3.5% and 0.31% of eyes, and posterior lens dislocation in 2% and 0% of eyes in groups 1 group 2, respectively (P<0.001 for all comparisons). " 01/01/1994 - "Transformation of the secondary conformational structure of the human lens capsule after traumatic lens subluxation in a patient was investigated by Fourier transform infrared (FT-IR) microscopic spectrometry. " 01/01/1994 - "Transformation of IR spectra of the human lens capsule due to traumatic lens subluxation and correlation with the excised and dried lens capsule under different treatments."
5.	Fibrillin-1IBA 04/01/2014 - "Results of fibrillin-1 gene analysis in children from inbred families with lens subluxation." 04/01/2013 - "In humans, mutations in the gene for fibrillin 1 (FBN1) underlie Marfan syndrome (MS), a disorder characterized by lens dislocation and other ocular symptoms. " 08/28/2006 - "Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene." 01/01/2012 - "Marfan's syndrome (MFS) is a systemic disorder of the connective tissues caused by insufficient fibrillin-1 microfibril formation and can cause cardiac complications, emphysema, ocular lens dislocation and severe periodontal disease. " 11/04/2011 - "Marfan syndrome (MFS) is a systemic disorder of the connective tissues caused by insufficient fibrillin-1 microfibril formation and can cause cardiac complications, emphysema, ocular lens dislocation, and severe periodontal disease. "
6.	NeodymiumIBA 10/01/2009 - "Although crystalline lens extraction may be required to clear the visual axis in mild to moderate lens subluxations, we propose insertion of a primary anterior chamber IOL without lens extraction in severe subluxations when the eye is optically aphakic or can be made functionally aphakic following neodymium:YAG laser zonulysis. " 02/01/1989 - "Neodymium:YAG laser zonulysis for treatment of lens subluxation." 10/01/1986 - "Neodymium:YAG laser iridotomy as a possible contribution to lens dislocation." 02/01/1989 - "Nine eyes with lens subluxation in seven patients (6 patients with Marfan's syndrome, 1 with idiopathic lens subluxation) were treated by neodymium:YAG (Nd:YAG) laser zonulysis. "
7.	CystathionineIBA 01/01/2021 - "Cystathionine β-synthase (CBS) deficiency has a wide clinical spectrum, ranging from neurodevelopmental problems, lens dislocation and marfanoid features in early childhood to adult onset disease with predominantly thromboembolic complications. " 04/01/1998 - "Ocular complications and a new surgical approach to lens dislocation in homocystinuria due to cystathionine-beta-synthetase deficiency." 12/01/1984 - "Homocystinuria due to cystathionine synthase deficiency is an autosomal recessive error of sulphur amino acid metabolism characterized clinically by lens dislocation, mental retardation, skeletal abnormalities and thromboembolic phenomena. "
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/01/2014 - "After treatment, IVIs of VEGF were given and vitreous tap was performed three times, followed by clinical observation of lens subluxation and scanning electronic microscope evaluation of the zonular fibers. " 01/01/2012 - "The mean vitreous level of VEGF was 15.14 ± 5.22 pg/ml in eyes with grade B PVR, 99.15 ± 38.58 pg/ml in eyes with grade C PVR, 4,534.01 ± 1,193.28 pg/ml in eyes with vitreous hemorrhage secondary to PDR, 5,157.29 ± 969.44 pg/ml in eyes with vitreous hemorrhage and tractional retinal detachment secondary to PDR, and 16.19 ± 5.76 pg/ml in eyes of the control group with traumatic lens dislocation. " 01/01/2014 - "After IVIs of plasmin and SF6, and VEGF and vitreous tap had been performed one to three times, lens subluxation was noted in 0%, 43%, 71%, 71%, and 86% of the eyes in group 1. After IVIs of plasmin, VEGF, and vitreous tap had been performed one to three times, lens subluxation was noted in 11%, 22%, 44%, 44%, and 67% of the eyes in group 2. The eyes in group 3 and 4 did not show signs of lens subluxation after VEGF IVIs and vitreous tap. " 01/01/2014 - "The incidence of lens subluxation increased following plasmin injections in the eyes, and this was aggravated by the subsequent high VEGF level in the eyes and vitreous tapping. " 01/01/2014 - "To investigate the rate of lens subluxation following plasmin and/or SF6 injections in eyes, and whether a subsequent elevated level of vascular endothelial growth factor (VEGF) and vitreous tap would aggravate subluxation. "
9.	Matrix Metalloproteinases (MMPs)IBA 07/01/2019 - "The association between TGFβ and MMP levels and the degree of lens dislocation was analyzed using Spearman's correlation test. " 06/01/2002 - "Lens dislocation in Marfan syndrome: potential role of matrix metalloproteinases in fibrillin degradation."
10.	Polymethyl Methacrylate (Sol)IBA 07/01/2020 - "The following factors were compared between eyes with and without retinal detachment: signalment, operated eye, cataract stage at the time of surgery, and presence or absence of the following: lens-induced uveitis (LIU), glaucoma, anterior vitreous presentation, lens subluxation, history of prophylactic retinopexy, diabetes mellitus, operating surgeon, concurrent prophylactic retinopexy, posterior capsular tear, phacoemulsification duration, use of automated anterior vitrectomy, placement of an artificial intraocular lens, and intraocular lens type (polymethyl methacrylate or acrylic foldable). " 11/01/1987 - "A higher incidence of lens subluxation, lens repositioning, corneal edema, and elevated intraocular pressure was observed in the eyes receiving STAAR silicone implants than in the eyes receiving IOLAB PMMA implants. "

Therapies and Procedures

1.	Intraocular Lenses (Intraocular Lens) 03/01/2010 - "The evaluated surgical treatment provided good intraocular lens and endocapsular ring position, with VA improvement Thus, this technique is a viable, effective and safe option for the visual rehabilitation of patients with congenital lens subluxation." 10/01/2018 - "To evaluate whether retropupillary fixation of the iris-claw intraocular lens (IOL) is a safe and effective treatment option in children with large lens subluxations. " 10/01/2018 - "Assessment of the safety and efficacy of primary retropupillary fixation of iris-claw intraocular lenses in children with large lens subluxations." 06/01/2022 - "32.3% had a lens dislocation and 67.7% had an intraocular lens dislocation. " 01/01/2022 - "Retropupillary iris claw lens versus Gore-Tex assisted scleral fixated intraocular lens in children with large lens subluxations."
2.	Vitrectomy 07/01/2001 - "As vitrectomy with PFCL simplifies surgical technique with good results and modern sulcus fixated IOL may be used during the same surgery offering visual restoration, we believe this combined technique must be recommended always after posterior lens dislocation, to prevent complications and to preserve visual acuity." 01/01/2020 - "A prospective interventional study was conducted consisting of 45 eyes of 44 children in age group 6-18y having >7 clock hours of lens subluxation who underwent lensectomy-vitrectomy followed by SSTIOL implantation. " 06/01/2004 - "The aim of this study is to determine the relationship between the cause of lens dislocation and visual outcomes with complications in patients undergoing trans pars plana vitrectomy (TPPV) and trans pars plana lensectomy (TPPL) for lens dislocation. " 11/08/2023 - "Visual Outcomes of Traumatic Lens Dislocations and Subluxations Managed by Pars Plana Vitrectomy and Lensectomy." 03/01/2020 - "Patients who underwent pars plana vitrectomy to treat traumatic lens subluxation and dislocation were retrospectively reviewed. "
3.	Phacoemulsification 01/01/2022 - "The study included 70 patients (73 eyes) after complicated phacoemulsification in combination with grade 2 lens subluxation. " 01/01/2022 - "Implantation of an iris-claw lens in the course of complicated phacoemulsification in lens subluxation significantly improves refractive outcomes of the implantation in comparison with transscleral IOL fixation. " 01/01/2020 - "Prevention of the anterior capsular contraction syndrome (ACCS) in the late postoperative period in patients with lens subluxation is a current problem of phacoemulsification (PE). " 01/01/2019 - "The right eye subsequently developed a ventral lens subluxation, and phacoemulsification and irrigation/aspiration were performed six months after the first procedure. " 01/01/2007 - "(1) CTR facilitates phacoemulsification with PC IOL implantation in lens subluxation. "
4.	Lasers (Laser) 01/01/2022 - "The combined use of a femtosecond laser, MCTR, and iris hooks is an effective and safe method for treating patients with lens subluxation and elevated IOP." 01/01/2022 - "To evaluate the outcomes of femtosecond laser, modified capsular tension ring, and iris hook-assisted surgical treatment of lens subluxation in patients with elevated intraocular pressure (IOP). " 01/01/2022 - "Two-Year Follow-Up of Clinical Efficacy of Femtosecond Laser, Modified Capsular Tension Ring, and Iris Hook-Assisted Surgical Treatment of Lens Subluxation in Patients with Elevated Intraocular Pressure." 03/01/2017 - "Occult lens subluxation related to laser peripheral iridotomy: A case report and literature review." 01/01/2012 - "We suspect that laser iridotomy may induce localized zonular dialysis that results in progressive zonular weakness, leading to lens dislocation."
5.	Intraocular Lens Implantation 11/01/2012 - "Scleral fixation of standard capsular tension ring and in-the-bag intraocular lens implantation in patients with severe lens subluxation." 03/01/2010 - "Intraocular lens implantation with one loop haptic amputated and supported above the endocapsular ring is an option for the congenital lens subluxation surgical treatment, promoting lens centralization and postoperative visual acuity improvement." 03/01/2010 - "[Intraocular lens implantation with one loop haptic amputated: a new propose to the subluxation lens surgical treatment]." 01/01/2021 - "The patient had a history of coconut hit into his left eye which resulted in traumatic anterior lens subluxation, for which he had undergone phacoemulsification and scleral-fixated intraocular lens implantation in the left eye. " 11/01/2021 - "Sutureless Scleral-Fixated Intraocular Lens Implantation in the Treatment of Congenital Lens Subluxation Related to Marfan Syndrome."