HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Legg-Perthes Disease (Perthes Disease)

Subscribe to New Research on Legg-Perthes Disease

A particular type of FEMUR HEAD NECROSIS occurring in children, mainly male, with a course of four years or so.

Also Known As:

Perthes Disease; Coxa Plana; Legg-Calve-Perthes Disease; Legg-Calvé-Perthes Syndrome; Disease, Legg-Calve-Perthes; Disease, Legg-Perthes; Disease, Perthes; Legg Calve Perthes Disease; Legg Calvé Perthes Syndrome; Legg Perthes Disease; Syndrome, Legg-Calvé-Perthes

Networked: 429 relevant articles (13 outcomes, 47 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 179
- Bone Diseases: 3566
  - Osteonecrosis: 3149
    - Femur Head Necrosis: 55
      - Legg-Perthes Disease: 429
        Osteochondritis deformans: 8
        Garret Tripp syndrome

Related Diseases

1.	Osteonecrosis (Kienbock's Disease)
2.	Inflammation
3.	Necrosis
4.	Congenital Abnormalities (Deformity)
5.	Osteoarthritis

Experts

1.	Kim, Harry K W: 8 articles (06/2015 - 12/2006)
2.	Little, David G: 5 articles (07/2014 - 07/2005)
3.	Joseph, Benjamin: 5 articles (06/2013 - 09/2003)
4.	Bowen, J Richard: 4 articles (10/2012 - 07/2006)
5.	Oh, Chang-Wug: 4 articles (09/2011 - 12/2006)
6.	Castañeda, Pablo: 3 articles (10/2014 - 10/2008)
7.	Cho, Tae-Joon: 3 articles (09/2013 - 10/2008)
8.	Park, Moon Seok: 3 articles (09/2013 - 10/2008)
9.	Yoo, Won Joon: 3 articles (09/2013 - 10/2008)
10.	Choi, In Ho: 3 articles (09/2013 - 10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Legg-Perthes Disease:

1.	alpha 1-Antitrypsin (alpha 1 Antitrypsin)IBA 03/01/1989 - "We confirmed a significantly greater level of alpha 1-antitrypsin in comparison with the control group, which may indicate a decrease in fibrinolytic activity and confirm the hypothesis that there is an intravascular pre-disposition towards the appearance of clots in the vascular system of the femoral head in patients with Perthes' disease."
2.	GadoliniumIBA 10/01/2014 - "Recent studies have suggested that perfusion magnetic resonance imaging (pMRI) using gadolinium contrast and a subtraction technique can provide useful prognostic information in Legg-Calvé-Perthes disease (LCPD) and allow earlier stratification for outcome. " 06/01/2011 - "The purpose of the present study was to evaluate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the detection of cartilage changes versus morphologic imaging in the long-term course of Legg-Calvé-Perthes disease (LCPD). " 03/01/2010 - "Diffusion-weighted imaging findings in Perthes disease with dynamic gadolinium-enhanced subtracted (DGS) MR correlation: a preliminary study." 06/01/2011 - "Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and morphologic MRI of cartilage in the long-term follow-up after Legg-Calvé-Perthes disease (LCPD)." 03/01/2010 - "Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in the long-term follow-up after Perthes disease."
3.	factor V LeidenIBA 01/01/2014 - "The factor V Leiden mutation is significantly related to Perthes disease, and its screening in at-risk children might be useful in the future." 11/01/2008 - "A systematic review of case-control studies suggested that there was a positive association between Perthes' disease and Factor V Leiden. " 10/01/2007 - "In a 4-generation kindred identified through a 12-year-old female proband with Legg-Calve-Perthes Disease (LCPD) who was found to be heterozygous for the G1691A factor V Leiden mutation (FV), our specific aim was to assess associations of FV with LCPD and with venous and arterial thrombotic events. " 10/01/2007 - "Legg-Calve-Perthes disease, venous and arterial thrombi, and the factor V Leiden mutation in a four-generation kindred." 07/01/2005 - "No association between factor V Leiden and Perthes' disease was observed. "
4.	Protein CIBA 05/01/2008 - "The inclusion criteria involved controlled studies, those that presented protein C as a continuous variable, and studies conducted in children with Perthes disease. " 03/01/2006 - "Protein C levels in patients with Legg-Calve-Perthes disease: is it a true deficiency?" 01/01/2000 - "Resistance to activated protein C (RPCA) and other congenital prethrombotic disorders have been recently reported to be strongly associated with Legg-Perthes disease. " 02/01/1999 - "From these data we conclude that in contrast to human, canine Morbus Perthes disease is most likely not caused by mutations within the protein C gene." 02/01/1999 - "We have cloned the canine protein C gene to investigate whether Morbus Perthes disease in dogs is also caused by mutations within this gene. "
5.	Insulin-Like Growth Factor I (IGF-1)IBA 07/01/1989 - "The purpose of this study was to examine plasma somatomedin-C activity in Perthes' disease using radioimmunoassay. " 08/01/1992 - "We studied Insulin-like Growth Factor I (IGF I) plasma levels, standing height, and weight in 59 consecutive children with Perthes' disease and 59 matched controls. " 08/01/1992 - "Low plasma levels of insulin-like growth factor I in Perthes' disease. " 01/01/1992 - "In this report for the first time sequential data are presented on plasma somatomedin-C (Sm-C/insulin-like growth factor I) levels in 21 boys with Perthes' disease. " 01/01/1992 - "No physiologic age-related increase of circulating somatomedin-C during early stage of Perthes' disease: a longitudinal study in 21 boys."
6.	Technetium Tc 99m MedronateIBA 02/01/1991 - "Thirty-two patients in whom Legg-Perthes disease apparently involved only one hip were examined with venography, measurement of intraosseous and intra-articular pressures, arthrography, and dynamic triphasic bone-imaging with 99mTc methylene diphosphonate. " 11/01/1992 - "Serial quantitative scintigraphic studies using 99mTc-methylene diphosphonate were performed on 25 hips with Legg-Perthes' disease to evaluate changes in local blood flow of the femoral head after subtrochanteric varizational and/or derotational osteotomy. " 01/01/1987 - "The 99mTc methylene diphosphonate (MDP) bone scan appearances in Perthes disease are well-known; in synovitis, the hip may show a diffuse increase in activity or may be normal. "
7.	Somatomedins (Somatomedin)IBA 08/01/1986 - "This paper reports a study of the serum somatomedin activity in 67 boys with Perthes' disease and in 43 control boys aged three to 11 years. " 07/01/1989 - "Therefore, caution is advisable before hypothesizing an etiology of Perthes' disease on the basis of results of plasma somatomedin concentration." 07/01/1989 - "In recent years, the association between somatomedin and Perthes' disease has been investigated. " 08/01/1986 - "Raised somatomedin activity in the serum of young boys with Perthes' disease revealed by bioassay. " 08/01/1986 - "These findings suggest a defect in the pituitary-somatomedin-target tissue axis in Perthes' disease."
8.	Prothrombin (Factor II)IBA 03/01/2001 - "For the presented group of children with Perthes' disease, we did not find an increased rate of factor V or prothrombin mutations compared to the natural incidence. " 03/01/2001 - "[Incidence of thrombophilic factor V Leiden and prothrombin G20210A mutation in Perthes disease--a pilot study]." 03/01/2001 - "We investigated whether children with Perthes' disease have an increased incidence of mutations of factor V (Leiden) and prothrombin (G2O210A), which predispose to thrombosis. " 01/01/2014 - "This study aimed to systematically review the association between genetic determinants of hypercoagulability (Factor V Leiden, prothrombin II, and methylenetetrahydrofolate reductase; MTHFR) and Perthes disease. " 01/01/2010 - "The incidence of Legg-Calvé-Perthes disease was increased in the presence of the factor V Leiden mutation (odds ratio, 3.3; 95% confidence interval, 1.6 to 6.7), in the presence of the prothrombin G20210A mutation (odds ratio, 2.6; 95% confidence interval, 1.0 to 6.3), in association with elevated levels of factor VIII (>150 IU/dL) (odds ratio, 7.5; 95% confidence interval, 2.2 to 25.2), and in association with protein S deficiency (<67 U/dL) (odds ratio, 2.8; 95% confidence interval, 0.7 to 10.8). "
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/01/2008 - "To make a rabbit model of Perthes disease and to explore the change and its significance of VEGF expression in the femoral head. " 07/01/2008 - "[An animal model of Perthes disease and an experimental research of VEGF expression]." 01/01/2014 - "Effects of circulating endothelial progenitor cells, serum vascular endothelial growth factor and hypogammaglobulinemia in Perthes disease." 01/01/2014 - "The aim of this study was to investigate Legg-Calvé-Perthes disease (PD) pathogenesis by comparing absolute circulating endothelial progenitor cell (EPC) counts, serum levels of vascular endothelial growth factor-A (VEGF-A) and immunoglobulins between PD patients and controls. "
10.	Interleukin-6 (Interleukin 6)IBA 07/01/2014 - "Association of gene variants in TLR4 and IL-6 genes with Perthes disease." 06/01/2015 - "Legg-Calvé-Perthes disease produces chronic hip synovitis and elevation of interleukin-6 in the synovial fluid." 07/01/2014 - "Since genetic studies related to inflammation have not been performed in Perthes disease so far, the aim of this study was to analyze the association of frequencies of genetic variants of immune response genes, toll-like receptor 4 (TLR4) and interleukin-6 (IL-6), with this disease. "

Therapies and Procedures

1.	Osteotomy 07/01/1980 - "A group of children with Legg-Calvé-Perthes disease (LCPD) who underwent femoral osteotomy were analyzed to define further those most likely to respond favorably to this procedure. " 08/01/2008 - "There is not always a good outcome after a femoral varus osteotomy (FVO) in those with Legg-Calvé-Perthes disease (LCPD), even when the severity warrants surgical treatment. " 11/01/2004 - "Good results are obtained as a result of varus-derotation subtrochanteric osteotomy in patients with Perthes' disease type III and IV according to Catterall, and lead to improvement in the congruency of the joint." 05/01/1999 - "The surgical treatment of Perthes' disease by femoral or innominate osteotomy is not as effective in those over the age of eight years as it is in the younger child. " 10/01/2012 - "According to the results reported here, the combined osteotomy is safe and effective procedure for patients with severe Perthes disease in whom the femoral head cannot be contained by conventional forms of treatment."
2.	Traction 10/30/2004 - "Treatment of Perthes' disease by using crutches to relieve limb load, and by applying kinesitherapy and traction, allows for good results, comparable to those achieved with other conservative methods. " 03/01/2006 - "The purpose of this study was to review radiological changes in LP grade in older patients with Perthes disease during 20 months of treatment with skin traction and ROM exercises. " 03/01/2006 - "Lateral and posterior pillar grade changes during the treatment of Perthes disease in older patients using skin traction and range of motion exercises." 01/01/1995 - "Evaluation of a home-based traction program for children with congenital dislocated hips and Legg Perthes disease." 01/01/1994 - "Home-based traction is an alternative treatment to conventional hospital-based traction for children with orthopedic conditions such as congenital dislocated hip and Legg-Perthes disease. "
3.	Decompression 02/01/1990 - "The results obtained have allowed to make a substantial contribution into the characteristics of the functional state of the hip joint in Perthes' disease and to make an objective evaluation of the efficacy of the surgical treatment consisting in using new methods with the aim of decompression and distraction on the basis of not only anatomic but also functional and biomechanical criteria of evaluation." 07/01/2011 - "Core decompression may be used as adjunct for treatment in some cases of Legg-Calvé-Perthes disease (LCPD). " 10/01/1989 - "The authors evaluate the results of 90 decompression operations in 68 patients with Perthes' disease at stages I-IV; the mean age of the children was 8.3 +/- 1.2 years and the follow-up period after the surgery was from 6 months to 10 years. " 10/01/1989 - "[Outcome of decompression operations in the treatment of Legg-Perthes disease]." 10/01/1986 - "[Decompression operation in the treatment of Perthes disease in children]."
4.	Debridement 09/01/2005 - "By diagnosis, significant improvement in HHS was seen for patients with isolated labral tears undergoing labral debridement (before surgery 57.6; after surgery 89.2; P < 0.001), for patients with Perthes disease undergoing chondroplasty and loose body excision (before surgery 49.5; after surgery 80.1; P < 0.001), and for patients with hip dysplasia after prior periacetabular osteotomy undergoing labral debridement (before surgery 51.8; after surgery 79.8; P < 0.001). "
5.	Splints 05/01/2012 - "The study comprised 143 patients with Legg-Calvé-Perthes disease, treated using a Thomas splint. " 09/01/2011 - "The study consisted of 74 patients with Legg-Calvé-Perthes disease treated using a Thomas splint. " 03/01/1997 - "A double-blind trial of the use of pulsed electro-magnetic frequency (PEMF) in the treatment of Perthes' disease was constructed by using this therapy to supplement a long-practised non-weight-bearing orthotic treatment, the Birmingham Containment Splint. " 07/01/1990 - "[Splint treatment of Perthes disease]." 01/01/1967 - "The results of treatment in Legg-Calve-Perthes disease using a Thomas splint."