HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)

An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
Also Known As:
Lecithin Cholesterol Acyltransferase; Acyltransferase, Lecithin Cholesterol; Cholesterol Ester Lysolecithin Acyltransferase; Lecithin Acyltransferase; Phosophatidylcholine-Sterol Acyltransferase; Acyltransferase, Lecithin; Acyltransferase, Phosophatidylcholine-Sterol; Cholesterol Acyltransferase, Lecithin; O-Acyltransferase, Phosphatidylcholine-Sterol; Phosophatidylcholine Sterol Acyltransferase; Phosphatidylcholine Sterol O Acyltransferase; Phosphatidylcholine:sterol O-acyltransferase
Networked: 497 relevant articles (12 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Calabresi, Laura: 12 articles (01/2021 - 06/2004)
2. Remaley, Alan T: 10 articles (01/2020 - 04/2009)
3. Kuroda, Masayuki: 7 articles (08/2022 - 02/2011)
4. Ossoli, Alice: 7 articles (01/2021 - 01/2016)
5. Freeman, Lita A: 7 articles (01/2020 - 01/2016)
6. Ng, Dominic S: 7 articles (12/2015 - 04/2002)
7. Franceschini, Guido: 6 articles (01/2019 - 06/2004)
8. Bujo, Hideaki: 6 articles (09/2018 - 02/2011)
9. Connelly, Philip W: 6 articles (06/2012 - 04/2002)
10. Karathanasis, Sotirios K: 5 articles (01/2022 - 01/2019)

Related Diseases

1. Atherosclerosis
2. Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)
3. Hyperlipidemias (Hyperlipidemia)
4. Nephrotic Syndrome (Syndrome, Nephrotic)
5. Cholesteryl Ester Transfer Protein Deficiency

Related Drugs and Biologics

1. Apolipoprotein A-I (Apolipoprotein A1)
2. Lipoproteins (Lipoprotein)
3. Proteins (Proteins, Gene)
4. Apolipoproteins E (ApoE)
5. Triglycerides (Triacylglycerol)
6. Cholesterol
7. Apolipoproteins
8. Cholesterol Ester Transfer Proteins
9. Phospholipid Transfer Proteins
10. Scavenger Receptors (Scavenger Receptor)

Related Therapies and Procedures

1. Therapeutics
2. Fat-Restricted Diet (Diet, Fat Restricted)
3. Ligation
4. Renal Dialysis (Hemodialysis)
5. Intravenous Administration