Lead Poisoning (Poisoning, Lead)

02/01/1996 - "To determine whether succimer (meso-2,3-dimercaptosuccinic acid) would be effective in reducing blood lead concentration in dogs with naturally acquired lead poisoning and whether treated dogs would develop clinically important adverse effects. "
11/30/2022 - "The RBCM-DMSA-NP treatment significantly extended the cycle time of the drug in the body and improved the survival rate of mice with chronic lead poisoning. "
08/01/1994 - "Renal clearance of total DMSA was greater in healthy adults (77.0 +/- 13.2 ml/min per square meter) than in either adults (24.7 +/- 3.3 ml/min per square meter) or children with lead poisoning (16.6 ml/min per square meter); renal clearance of the metabolites of DMSA was also greater in healthy adults (64.6 +/- 10.1 ml/min per square meter) than in either adults (35.4 +/- 8.4 ml/min per square meter) or children with lead poisoning (19.5 ml/min per square meter). "
01/01/1992 - "We conclude that a 5-day oral course of DMSA is effective in the treatment of children with severe lead poisoning. "
08/01/2009 - "This article reviews data on the efficacy of succimer (dimercaptosuccinic acid, DMSA) in the treatment of human inorganic lead poisoning, the adverse effects associated with its use, and summarizes current understanding of the pharmacokinetic and pharmacodynamic aspects. "

11/01/1977 - "Diagnosis of lead poisoning was confirmed on the basis of blood lead concentrations ranging from 146 microgram/100 ml to 378 microgram/100 ml. These 4 cranes were treated successfully with calcium disodium edetate intramuscularly. "
09/01/1996 - "Treatment with EDTA lead mobilization is effective for acute lead poisoning while avoidance of further lead exposure prevents recurrence of lead intoxication. "
04/01/1992 - "Published recommendations (1985) for the management of childhood lead poisoning suggest the use of ethylenediaminetetraacetic acid (EDTA) provocation testing and chelation as the mainstay of treatment for blood lead levels between 25 and 55 micrograms/dL. "
11/01/1961 - "[The efficacy of Ca-EDTA treatment for the prevention of lead poisoning]."
03/01/1963 - "[Study of the effectiveness and persistence of the therapeutic action of CaNa2 EDTA in lead poisoning]."

09/01/2009 - "The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning."
07/01/2019 - "d-Penicillamine was effective in the treatment of lead poisoning among children. "
01/01/2019 - "Background The aim of the current study was to evaluate the efficacy of D-penicillamine in the treatment of lead poisoning mainly in the outpatient setting. "
01/01/2019 - "Methods In a case series study performed during the recent epidemic of lead poisoning in Iran, lead-poisoned patients referring to our outpatient clinic were treated with 250-mg D-penicillamine capsules administered every 6 h for 5 or 10 days based on availability of the medication. "
01/01/2019 - "Conclusions D-penicillamine may be an acceptable substitute treatment in adult lead poisoning. "

04/01/2023 - "Furthermore, it also focuses on synthetic chelators used in the treatment of lead poisoning and the advantage of using bioactive compounds with an emphasis on the ameliorative effect of garlic."
10/15/2021 - "Our results suggest that treatment with chelating agents combined with the prevention of environmental exposure may be an excellent strategy to reduce the rate of lead poisoning. "
10/01/2019 - "He had been treated with lead chelators for lead poisoning. "
01/01/2016 - "Because our repeated evaluations were negative, we decided to re-treat lead poisoning by intravenous and intramuscular chelators. "
07/01/2014 - "The treatment of choice for lead poisoning is the administration of chelating agents and removal of the lead source by surgical intervention."

01/01/2004 - "A randomized trial of calcium supplementation for childhood lead poisoning."
12/01/1990 - "[Experimental study of the protective role of calcium in lead poisoning]."
05/01/1968 - "Studies with calcium ethylenediaminetetraacetate in calves; toxicity and use in bovine lead poisoning."
08/13/2015 - "Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload."
06/01/1992 - "Twenty-seven wild geese (Anser albifrons) suffering from lead poisoning caused by ingestion of lead shot were treated with disodium calcium ethylenediaminetetraacetate. "

01/15/2022 - "This study demonstrated the success of control policies for lead-acid battery manufacturers in promoting the prevention and control of childhood lead poisoning in China. "
01/01/2021 - "We collected 10 562 data sets on Pb-B, ALA-U, age, and smoking habits from 808 workers (771 males and 37 females) who underwent multiple lead poisoning medical examinations at a lead-acid battery and lead smelting plant in Japan between 1995 and 2018. "
11/19/2018 - "Lead poisoning is a common disease in lead-acid battery manufacturing industries. "
01/01/2018 - "The village's population had been subject to severe lead poisoning for at least a decade as a result of informal Used Lead Acid Battery (ULAB) recycling. "
06/01/2008 - "This article describes an entire family manufacturing lead acid batteries who all suffered from lead poisoning. "

07/01/2007 - "Lead poisoning was diagnosed in three cattle along with increased mercury levels in the liver and kidney tissues of two of these animals. "
02/15/1974 - "[Mercury and lead poisonings in the light of the 16th to 18th century literature]."
01/01/1954 - "[Olfactometry in mercury and lead poisonings]."
05/15/1979 - "[Renal failure caused by mercury and lead poisoning in the calf (author's transl)]."
05/01/1980 - "Mercapto steroids in protection against mercury and lead poisoning."

12/01/2021 - "Although some of the intervention programs of counteracting lead poisoning by iron supplementation proved to be effective in the Pb-exposed population, the exact mechanisms of this interaction still require further studies. "
01/01/2022 - "The purpose of this article was to summarize the current understanding of cellular mechanisms of lead toxicity and present a comprehensive review of existing clinical trials related to associations of lead poisoning and iron status. "
09/01/2004 - "Future clinical trials are necessary to assess the effect of iron supplementation in the public health prevention of lead poisoning and the kinetics of lead in the body."
09/01/2004 - "Recent human studies suggest that high iron intake and sufficient iron stores may reduce the risk of lead poisoning. "
06/01/1999 - "Improvements in developmental assessment scores and decreases in blood lead in iron-replete children with lead poisoning secondary to iron supplements have not been demonstrated in clinical studies. "

11/15/2000 - "Can antioxidants be beneficial in the treatment of lead poisoning?"
11/15/2000 - "To explain the importance of using antioxidants in treating lead poisoning the following topics are addressed: (i) Oxidative damage caused by lead poisoning; (ii) conventional treatment of lead poisoning and its side effects; and (iii) possible protective effects of antioxidants in lead toxicity."
01/01/2014 - "This suggests that some antioxidants may play a role in the treatment of lead poisoning. "
04/01/2012 - "Using antioxidants is an important means of treating lead poisoning. "
10/30/2002 - "Lead-induced oxidative stress contributes to the pathogenesis of lead poisoning for disrupting the delicate prooxidant/antioxidant balance that exists within mammalian cells. "

10/27/1995 - "Erythrocyte protoporphyrin was eliminated as a method of lead screening in February 1993; since then, all children in the state have been screened for lead poisoning by testing capillary or venous blood samples for lead. "
09/01/2021 - "Suspicion of lead poisoning is confirmed by its concentration in blood and protoporphyrin red blood cells. "
12/01/2015 - "The discrepant earlier reports, which sometimes caused the diagnosis to be missed initially, were from laboratories that measure protoporphyrin only by hematofluorometry, which is intended primarily to screen for lead poisoning. "
03/01/1993 - "The third factor correlated the frequency of previous lead poisonings with the renal blood flow, erythrocytic protoporphyrin and age. "
01/01/1993 - "In 1973, erythrocyte protoporphyrin screening transformed testing for lead poisoning. "

03/01/1997 - "In summary, LXRF estimates of Pb in tibial cortical bone have yielded highly relevant clinical data relating to the efficacy of chelation therapy with CaNa2EDTA in lead poisoned children; diagnostic approach(es) to childhood lead poisoning; and evaluations of exposure in children, teenagers, and adults in lead-exposed and non-lead-exposed suburban communities. "
01/01/1988 - "Two children with lead poisoning had delayed conduction in the peripheral pathways only and in these there was good correlation between the degree of delay and the ulnar nerve conduction velocity; both improved after chelation therapy. "
05/30/2024 - "We therefore considered lead poisoning, and the patient improved after chelation therapy. "
11/30/2022 - "Chelation therapy is usually used to manage lead poisoning. "
01/01/2022 - "Consent was obtained from 42 individuals diagnosed with lead poisoning and blood and urine samples were collected before and after chelation therapy. "

02/01/1989 - "Lead poisoning was detected and chelating therapy induced a marked improvement of the clinical symptoms. "
01/01/1989 - "Lead poisoning was detected in this patient and the chelating therapy induced a marked improvement of the clinical symptoms."
06/01/2010 - "We conducted a population-based study to examine the relationship among geometric mean BLLs in children (i) born before any lead poisoning prevention activities were instituted, (ii) born when specific interim interventions were instituted and (iii) born after relocation and medical therapy were available. "
11/01/1957 - "[Therapy of lead poisoning; experimental study with piro-na]."
01/01/2021 - "We demonstrate curative therapy for lead poisoning through the use of minimally invasive arthroscopic techniques for removal of retained intra-articular lead missiles."

01/01/2022 - "Hemoperfusion is a powerful and yet simple method for lead poisoning treatment, but creation of safe and effective sorbents with excellent selectivity remains a real challenge. "
01/01/2017 - "Rabbit lead poisoning models were established to study the adsorption rate; then, a pig hemoperfusion experiment was used for further validation. "

08/01/2021 - "The patient's encephalopathy improved throughout her hospital course, and she was discharged on hospital day 8. Following five days of EDTA and three days of BAL injections, her repeat BLL was 15.3 µg/dL. SIADH has been associated with severe lead poisoning and may be more likely to occur in high risk patients such as individuals with sickle cell anemia, particularly where medications are used that may cause iatrogenic hyponatremia."
08/01/2004 - "injections, the fructose-amino acids were effective antagonists of lead poisoning under the experimental conditions. "

08/01/1999 - "Although the numbers of workers performing lead abatement projects were small, the trend for lower BLL in this group provides evidence that training, implementation of engineering controls, and proper use of personal protective equipment such as respirators is effective in controlling lead poisoning."