Lead Poisoning (Poisoning, Lead)

02/01/1996 - "To determine whether succimer (meso-2,3-dimercaptosuccinic acid) would be effective in reducing blood lead concentration in dogs with naturally acquired lead poisoning and whether treated dogs would develop clinically important adverse effects. "
08/01/1994 - "Renal clearance of total DMSA was greater in healthy adults (77.0 +/- 13.2 ml/min per square meter) than in either adults (24.7 +/- 3.3 ml/min per square meter) or children with lead poisoning (16.6 ml/min per square meter); renal clearance of the metabolites of DMSA was also greater in healthy adults (64.6 +/- 10.1 ml/min per square meter) than in either adults (35.4 +/- 8.4 ml/min per square meter) or children with lead poisoning (19.5 ml/min per square meter). "
01/01/1992 - "We conclude that a 5-day oral course of DMSA is effective in the treatment of children with severe lead poisoning. "
06/01/2001 - "Although succimer (Chemet, meso-2,3-dimercaptosuccinic acid, DMSA) is considered to be a safe and effective chelating agent for the treatment of lead poisoning in humans, there is concern that it may increase the gastrointestinal (GI) absorption and retention of Pb from exposures suffered concurrent with treatment. "
06/01/1998 - "The aim of this study was to evaluate the efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) treatment in workers with increased lead absorption and no overt symptoms of lead poisoning. "

11/01/2014 - "They were diagnosed with lead poisoning later and were treated successfully with lead chelator (CaNa2 EDTA). "
11/01/1977 - "Diagnosis of lead poisoning was confirmed on the basis of blood lead concentrations ranging from 146 microgram/100 ml to 378 microgram/100 ml. These 4 cranes were treated successfully with calcium disodium edetate intramuscularly. "
09/01/1996 - "Treatment with EDTA lead mobilization is effective for acute lead poisoning while avoidance of further lead exposure prevents recurrence of lead intoxication. "
04/01/1992 - "Published recommendations (1985) for the management of childhood lead poisoning suggest the use of ethylenediaminetetraacetic acid (EDTA) provocation testing and chelation as the mainstay of treatment for blood lead levels between 25 and 55 micrograms/dL. "
11/01/1961 - "[The efficacy of Ca-EDTA treatment for the prevention of lead poisoning]."

01/01/2004 - "A randomized trial of calcium supplementation for childhood lead poisoning."
12/01/1990 - "[Experimental study of the protective role of calcium in lead poisoning]."
05/01/1968 - "Studies with calcium ethylenediaminetetraacetate in calves; toxicity and use in bovine lead poisoning."
01/01/2015 - "Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload."
06/01/1992 - "Twenty-seven wild geese (Anser albifrons) suffering from lead poisoning caused by ingestion of lead shot were treated with disodium calcium ethylenediaminetetraacetate. "

09/01/2009 - "The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning."
05/01/2012 - "The aim of this study was to investigate therapeutic effects of garlic and compare it with d-penicillamine in patients with chronic lead poisoning. "
12/01/2014 - "A spectroscopic investigation of the complexes formed between the Pb(II) ion and D-penicillamine (H2Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with CPb(II) ≈ 10 and 100 mM, varying the H2Pen/Pb(II) molar ratio (2.0, 3.0, 4.0, 10.0). "
05/01/2012 - "Comparison of therapeutic effects of garlic and d-Penicillamine in patients with chronic occupational lead poisoning."
01/01/2000 - "Adverse effects of reduced-dose d-penicillamine in children with mild-to-moderate lead poisoning."

07/01/2007 - "Lead poisoning was diagnosed in three cattle along with increased mercury levels in the liver and kidney tissues of two of these animals. "
02/15/1974 - "[Mercury and lead poisonings in the light of the 16th to 18th century literature]."
01/01/1954 - "[Olfactometry in mercury and lead poisonings]."
03/01/1986 - "Selected clusters are here reviewed in relation to suspected sources of heavy metal (mercury, lead) poisoning as background for the analysis of the 1983-1985 "outbreak" of 30-40 cases of multiple sclerosis in Key West, Florida. "
05/15/1979 - "[Renal failure caused by mercury and lead poisoning in the calf (author's transl)]."

11/15/2000 - "Can antioxidants be beneficial in the treatment of lead poisoning?"
11/15/2000 - "To explain the importance of using antioxidants in treating lead poisoning the following topics are addressed: (i) Oxidative damage caused by lead poisoning; (ii) conventional treatment of lead poisoning and its side effects; and (iii) possible protective effects of antioxidants in lead toxicity."
04/01/2012 - "Prior in vivo studies showed marked differences between various chelator antioxidants in their ability to decrease both blood Pb(II) levels and oxidative stress resulting from lead poisoning. "
01/01/2014 - "This suggests that some antioxidants may play a role in the treatment of lead poisoning. "
04/01/2012 - "Using antioxidants is an important means of treating lead poisoning. "

03/01/1989 - "This paper demonstrates the efficacy of screening for lead poisoning by determining FEP for a rapid, accurate identification of children at risk and in need of treatment. "
09/01/1989 - "Therefore, the degree of lead poisoning can't be classified by the values of FEP, ZPP among plumbism."
06/01/1983 - "Since the early 1970s, measurement of free erythrocyte protoporphyrin (FEP) (by microextraction or by hematofluorometer) has been widely used to screen for lead poisoning and to evaluate microcytic red blood cell (RBC) disorders in children. "
07/01/1981 - "Under the lead exposure levels of these painters (PbB 5-50 microgram/dl, PbU 10-200 microgram/l), FEP alone, among the four biochemical tests for lead poisoning, showed a different behaviour between the male and female painters. "
07/01/1981 - "Females painters of ceramic works were examined for parameters of biochemical lead poisoning such as erythrocyte ALAD, free erythrocyte protoporphyrin (FEP), ALA and coproporphyrin (CP) in the urine as well as parameters of lead absorption such as lead concentration in the blood and urine (PbB and PbU). "

06/01/2012 - "Modulation of cellular thiols for protection against reactive oxygen species (ROS) has been used as a therapeutic strategy against lead poisoning. "
09/01/2003 - "Recent studies have shown that lead causes oxidative stress by inducing the generation of reactive oxygen species (ROS) and reducing the antioxidant defense system of cells, which suggests that antioxidants may play an important role in the treatment of lead poisoning. "
09/01/1993 - "5-Aminolevulinic acid (ALA), a heme precursor accumulated in lead poisoning and acute intermittent porphyria, is known to undergo metal-catalyzed aerobic oxidation to yield reactive oxygen species. "
08/01/1991 - "1. The enolamine form of 5-aminolaevulinic acid (ALA), a haem precursor that accumulates in lead poisoning and in acute intermittent porphyria (AIP), undergoes fast autoxidation at slightly alkaline pH with concomitant generation of reactive oxygen species. "
01/01/2002 - "5-Aminolevulinic acid (ALA) is a heme precursor that accumulates in some porphyric disorders and in lead poisoning which can undergo metal-catalyzed oxidation producing reactive oxygen species and the keto-aldehyde, 4,5-dioxovaleric acid (DOVA). "

12/01/1986 - "A comparative study on the effect of oral and subcutaneous (sc) or intravenous (iv) administration of S-adenosyl-L-methionine (SAM) in lead poisoning was carried out. "
09/01/1956 - "[Inclusion of methionine into actomyosin and into muscle tissue in chronic lead poisoning]."
09/01/1989 - "The influence of methionine supplementation on the efficacy of common antidotes to lead poisoning, calcium disodium ethylenediaminetetraacetate (CaNa2EDTA) and D-penicillamine (DPA), was investigated in rats. "

01/01/2005 - "Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning."
04/01/1984 - "Karyorrhexis or marked dyserythropoiesis in the peripheral smear, not heretofore described in arsenic or lead poisoning, may indeed be a unique hematologic clue. "
11/01/1994 - "We report the case of an Asian woman who was exposed to toxic levels of lead, arsenic and mercury through the use of Indian ethnic remedies, and who suffered symptomatic lead poisoning. "

03/01/1997 - "In summary, LXRF estimates of Pb in tibial cortical bone have yielded highly relevant clinical data relating to the efficacy of chelation therapy with CaNa2EDTA in lead poisoned children; diagnostic approach(es) to childhood lead poisoning; and evaluations of exposure in children, teenagers, and adults in lead-exposed and non-lead-exposed suburban communities. "
01/01/1988 - "Two children with lead poisoning had delayed conduction in the peripheral pathways only and in these there was good correlation between the degree of delay and the ulnar nerve conduction velocity; both improved after chelation therapy. "
09/01/1991 - "Although both patients improved with several months of intramuscular chelation therapy, the efficacy of such therapy in chronic lead poisoning is controversial. "
01/01/2015 - "Standard chelation therapy in different groups and up-to-date less toxic new medications for the treatment of lead poisoning are finally discussed. "
04/01/2012 - "Our goal was to determine the cause of the childhood lead poisoning outbreak, investigate risk factors for child mortality, and identify children < 5 years of age in need of emergency chelation therapy for lead poisoning. "

08/01/1999 - "Although the numbers of workers performing lead abatement projects were small, the trend for lower BLL in this group provides evidence that training, implementation of engineering controls, and proper use of personal protective equipment such as respirators is effective in controlling lead poisoning."

11/01/2006 - "A window replacement policy will yield multiple benefits of lead poisoning prevention, increased home energy efficiency, decreased power plant emissions, improved housing affordability, and other previously unrecognized benefits. "

01/01/1993 - "Diagnosis and treatment of chronic lead poisoning in CAPD patients."
01/01/1993 - "These results suggest that ALAD assay followed by the EDTA mobilization test is as effective in CAPD patients as in NRF subjects to diagnose and to treat chronic abstruse lead poisoning."
01/01/1993 - "In order to screen for abstruse lead poisoning in continuous ambulatory peritoneal dialysis (CAPD) patients, delta-aminolevulinic acid dehydratase (ALAD) levels were measured in 18 CAPD patients, 156 patients treated with hemodialysis (HD), and 420 control patients with normal renal function (NRF). "

09/01/1966 - "[Study in chemotherapy of experimental lead poisoning. "
09/01/1966 - "[Study on the chemotherapy of experimental lead poisoning. "
11/01/1999 - "meso-2,3-Dimercaptosuccinic acid is a suitable chelating agent for routine pharmacotherapy of lead poisoning in children. "
05/01/1977 - "Dense metaphyses simulating the appearance of lead poisoning developed in 20 of 58 patients during chemotherapy."
03/03/2006 - "Health-care providers who are unfamiliar with chelating agents and are considering this treatment for lead poisoning should consult an expert in the chemotherapy of lead poisoning. "