Laurence-Moon Syndrome (Syndrome, Laurence-Moon)

An autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)

Also Known As:

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl)
2.	Leber Congenital Amaurosis
3.	Usher Syndromes (Usher Syndrome)
4.	Retinitis Pigmentosa (Pigmentary Retinopathy)
5.	Retinal Degeneration

Experts

1.	Ahmed, Zubair M: 1 article (02/2015)
2.	Anderson, Yvonne: 1 article (02/2015)
3.	Arno, Gavin: 1 article (02/2015)
4.	Dattani, Mehul T: 1 article (02/2015)
5.	Dieterich, Klaus: 1 article (02/2015)
6.	Dollfus, Helene: 1 article (02/2015)
7.	Fink, John K: 1 article (02/2015)
8.	Grabowski, Gregory A: 1 article (02/2015)
9.	Gregory, Louise C: 1 article (02/2015)
10.	Hegde, Rashmi S: 1 article (02/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Laurence-Moon Syndrome:

1.	Gonadal HormonesIBA 03/01/1987 - "The apparent hypogonadism in patients with the Laurence-Moon syndrome has been variably attributed to unresponsiveness of target organs to gonadal hormones, primary end-organ failure, hypothalamic dysfunction, or pituitary failure. "
2.	Vitamin A (Retinol)FDA LinkGeneric 05/01/1985 - "Vitamin A nutrition in the Laurence-Moon-Biedl syndrome. "
3.	Retinaldehyde (Retinal)IBA 09/01/2007 - "The retinal ciliopathies include retinitis pigmentosa, macular degeneration, cone-dystrophy, cone-rod dystrophy, Leber congenital amaurosis, as well as retinal degenerations associated with Usher syndrome, primary ciliary dyskinesia, Senior-Loken syndrome, Joubert syndrome, Bardet-Biedl syndrome, Laurence-Moon syndrome, McKusick-Kaufman syndrome, and Biemond syndrome. "
4.	Glucose (Dextrose)FDA LinkGeneric 12/10/1976 - "[3 cases of Laurence-Moon-Biedl syndrome, with special reference to glucose tolerance]."
5.	Pentetic Acid (DTPA)FDA LinkGeneric 05/01/1997 - "We report a 7-year-old child with Laurence-Moon-Biedl syndrome, an autosomal recessive syndrome, with impaired renal function detected by means of technetium-99m diethylenetriamine-pentaacetic acid (Tc-99m DTPA), technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) scintigraphy, and ultrasonography. "
6.	Succimer (Dimercaptosuccinic Acid)FDA Link 05/01/1997 - "We report a 7-year-old child with Laurence-Moon-Biedl syndrome, an autosomal recessive syndrome, with impaired renal function detected by means of technetium-99m diethylenetriamine-pentaacetic acid (Tc-99m DTPA), technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) scintigraphy, and ultrasonography. "
7.	neurotoxic esteraseIBA 02/01/2015 - "Eight mutations in six families with Oliver-McFarlane or Laurence-Moon syndrome were identified in the PNPLA6 gene, which encodes neuropathy target esterase (NTE). "

Therapies and Procedures

1.	Kidney Transplantation 04/01/1994 - "Two cases of renal transplantation in pediatric patients with Laurence-Moon-Biedl syndrome are reported. " 04/01/1994 - "Pediatric renal transplantation in Laurence-Moon-Biedl syndrome." 01/01/1991 - "Renal transplantation in the Bardet-Biedl syndrome, a form of Laurence-Moon-Biedl syndrome."
2.	Therapeutics 09/01/2003 - "This genetic association between Laurence-Moon-Biedl syndrome and psoriasis can contribute to the understanding of the factors involved in the initiation of psoriasis and factors that modulate its severity and resistance to therapy."