Lathyrism

A paralytic condition of the legs caused by ingestion of lathyrogens, especially BETA-AMINOPROPIONITRILE or beta-N-oxalyl amino-L-alanine, which are found in the seeds of plants of the genus LATHYRUS.

Also Known As:

Networked: 203 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cicatrix (Scar)
2.	Pathologic Constriction (Stenosis)
3.	Motor Neuron Disease (Primary Lateral Sclerosis)
4.	Lathyrism
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1.	Lambein, Fernand: 10 articles (11/2012 - 02/2002)
2.	Ikegami, Fumio: 5 articles (05/2014 - 04/2003)
3.	Kusama-Eguchi, Kuniko: 5 articles (05/2014 - 07/2004)
4.	Ravindranath, Vijayalakshmi: 5 articles (01/2008 - 05/2002)
5.	Watanabe, Kazuko: 4 articles (05/2014 - 07/2004)
6.	Kusama, Tadashi: 4 articles (05/2014 - 07/2004)
7.	Kuo, Yu-Haey: 4 articles (03/2011 - 04/2003)
8.	Getahun, Haileyesus: 4 articles (03/2007 - 02/2002)
9.	Suda, Atsuhiro: 3 articles (05/2014 - 07/2004)
10.	Diwakar, Latha: 3 articles (07/2007 - 12/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lathyrism:

1.	CollagenIBA 12/01/2011 - "In the present study a rat animal model of lathyrism was employed to decipher whether anatomically confined alterations in collagen cross-links are sufficient to influence the mechanical properties of whole bone. " 01/01/1983 - "This histologic study of the periodontium of male white rats with chronic lathyrism demonstrates the appearance, progression, and persistence of certain pathologic changes caused by disordered collagen synthesis and maturation. " 09/01/1975 - "Several classic studies suggest that experimental lathyrism is not only based on an extracellular distrubance of collagen fibre maturation but on a disturbed cellular energy metabolism. " 09/01/1973 - "[Histological study of insoluble collagen of the epiphyseal cartilage in lathyrism]." 06/01/1965 - "EXTRACTABLE COLLAGEN IN THE NORMAL AND ANEURYSMAL AORTA: STUDIES IN LATHYRISM."
2.	oxalyldiaminopropionic acidIBA 03/01/2011 - "Exploitable genetic variability for β-ODAP has been observed for development of low ODAP varieties, which along with improved agronomic and detoxification practices can help reduce the risk of lathyrism. " 07/15/2015 - "Grass pea (Lathyrus sativus L.) cultivation is limited because of the presence in seeds and tissues of the nonprotein amino acid β-N-oxalyl-L-α,β-diaminopropionic acid (β-ODAP), a neurotoxin that can cause lathyrism in humans. " 05/01/2015 - "Heavy consumption of these species can lead to lathyrism, caused by the non-protein amino acid β-N-oxalyl-l-α,β-diaminopropionic acid (β-ODAP). " 07/01/2014 - "The cases of neurolathyrism declined in all the studied villages due to reduced β-ODAP exposure through Lathyrus sativus consumption, however, the grass pea was cultivated and consumed in Gondia district of Maharashtra State." 07/01/2014 - "Neurolathyrism is a non progressive motor neuron disorder engendered by the prolonged over-consumption of Lathyrus sativus (grass pea) seeds which contain a neurotoxic amino acid, β-N oxalyl- L-α, β-diaminopropionic acid (β-ODAP). "
3.	Penicillamine (Cuprimine)FDA Link 07/01/1992 - "Penicillamine-induced intradermal vesicles: an example of human lathyrism." 01/01/1981 - "Peripheral nerve regeneration in primates during D-penicillamine-induced lathyrism." 07/01/1969 - "3. Possible roles of the lysosomal collagenolytic enzyme system in experimental lathyrism in rats given penicillamine, and in erosion of cartilage in rheumatoid arthritis, are considered. " 11/01/1987 - "Since the principles of induced lathyrism have not been applied to the treatment of laryngotracheal stenosis, a pilot study using a canine model was conducted to test the efficacy of penicillamine and N-acetyl-L-cysteine in reduction of the rate of reformation of SGS. " 01/01/1981 - "We have attempted to alter collagen metabolism in young squirrel monkeys by inducing lathyrism with D-penicillamine to weaken scar tissue. "
4.	Caseins (Casein)FDA Link 01/01/1960 - "[Protection by alimentary casein against osseous lesions of lathyrism in the male rat. " 03/01/1954 - "Partial protection against odoratism (sweet pea lathyrism) by diets high in gelatin or casein."
5.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/01/1985 - "Protective role of vitamin C against neurolathyrism in guinea pigs." 03/01/2004 - "Ascorbic acid administration significantly improved dermal collagen structure and serum cytokine levels in experimental lathyrism." 03/01/2004 - "We investigated the effects of ascorbic acid on collagen structure and serum cytokine levels in experimentally induced lathyrism. " 03/01/2004 - "The role of ascorbic acid on collagen structure and levels of serum interleukin-6 and tumour necrosis factor-alpha in experimental lathyrism."
6.	GelatinIBA 03/01/1954 - "Partial protection against odoratism (sweet pea lathyrism) by diets high in gelatin or casein."
7.	ColchicineFDA LinkGeneric 05/01/1981 - "This data supports the hypothesis that lathyrism and colchicine therapy exert a measurable beneficial effect on surface scar in human beings." 05/01/1981 - "Therefore, treatment of patients with abnormal deposits of surface scar by excising the scar, inducing lathyrism, and administering colchicine should tend to correct abnormal balance between collagen synthesis and collagenolysis and result in a small scar with improved physical properties. " 05/01/1981 - "A hypothetical basis for control of surface scar in human beings is: lathyrism produces poorly cross-linked collagen in healing wounds; poorly corss-linked collagen is more susceptible to digestion by tissue collagenase than is normally cross-linked collagen; and colchicine stimulates tissue collagenase activity. " 05/01/1981 - "Ten patients with massive keloids, resistant to conventional therapy by excision, grafting, and/or intralesional injection of steroids, have been treated by excising the keloid, grafting the defect, inducing lathyrism with Beta aminopropionitrile fumurate or penicillamine and administering colchicine. "
8.	Arsanilic Acid (Atoxyl)IBA 06/01/1972 - "Protection against the neurolathyrism produced by arsanilic acid in the rat."
9.	Acetylcysteine (Siran)FDA LinkGeneric 11/01/1987 - "Since the principles of induced lathyrism have not been applied to the treatment of laryngotracheal stenosis, a pilot study using a canine model was conducted to test the efficacy of penicillamine and N-acetyl-L-cysteine in reduction of the rate of reformation of SGS. "
10.	AminopropionitrileIBA 07/01/1964 - "LATHYRISM OF MICE; BONY CHANGES INDUCED BY BETA-AMINOPROPIONITRILE FEEDING AND AUTORADIOGRAPHIC STUDY OF BONES USING S35." 09/03/1988 - "The cause of the increased egg weight in hens with lathyrism was investigated by feeding laying birds with diets containing beta-aminopropionitrile, the toxic principle of certain legume seeds in the genus Lathyrus. " 11/01/1983 - "Some species of lathyrus, notably Lathyrus odoratus, are unable to induce human lathyrism but contain a compound, beta-aminopropionitrile (BAPN), that induces pathological changes in bone ("osteolathyrism") and blood vessels ("angiolathyrism") of experimental animals without damaging the nervous system. " 10/01/1957 - "Experimental lathyrism in mice fed diets containing sweet peas or beta-aminopropionitrile." 03/01/2015 - "A mouse model of lathyrism using subcutaneous injection of up to 500 mg/kg β-aminopropionitrile (BAPN) was developed and characterized (60 animals across 4 dosage groups). "

Therapies and Procedures

1.	Subcutaneous Injections 03/01/2004 - "Experimental lathyrism was induced with daily subcutaneous injections of beta-APN in the test groups for 40 days. " 03/01/2015 - "A mouse model of lathyrism using subcutaneous injection of up to 500 mg/kg β-aminopropionitrile (BAPN) was developed and characterized (60 animals across 4 dosage groups). "
2.	Intralesional Injections 05/01/1981 - "Ten patients with massive keloids, resistant to conventional therapy by excision, grafting, and/or intralesional injection of steroids, have been treated by excising the keloid, grafting the defect, inducing lathyrism with Beta aminopropionitrile fumurate or penicillamine and administering colchicine. "
3.	Vegetarian Diet (Vegetarianism) 08/01/1985 - "These disorders occur in geographic isolates in several developing countries and are associated with malnutrition, cyanide intoxication from cassava consumption, tropical malabsorption (TM), vegetarian diets, and lathyrism. "
4.	Hypophysectomy 09/01/1957 - "Effect of hypophysectomy ans substitution therapy with STH upon experimental bone lathyrism."
5.	Anesthesia 03/01/1989 - "[Lathyrism and anesthesia: apropos of a case]."