Laryngitis

Inflammation of the LARYNGEAL MUCOSA, including the VOCAL CORDS. Laryngitis is characterized by irritation, edema, and reduced pliability of the mucosa leading to VOICE DISORDERS such as APHONIA and HOARSENESS.

Also Known As:

Networked: 497 relevant articles (34 outcomes, 61 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pharyngitis (Sore Throat)
2.	Gastroesophageal Reflux (GERD)
3.	Hoarseness
4.	Cough
5.	Peptic Esophagitis (Reflux Esophagitis)

Experts

1.	Vaezi, Michael F: 5 articles (09/2010 - 02/2006)
2.	Rizzo, Luiz Vicente: 4 articles (06/2017 - 10/2004)
3.	Martins, Regina Helena Garcia: 3 articles (03/2021 - 11/2012)
4.	Tavares, Elaine Lara Mendes: 3 articles (03/2021 - 11/2012)
5.	Eckley, Claudia A: 3 articles (06/2017 - 10/2004)
6.	Vaezi, M F: 3 articles (05/2013 - 06/2007)
7.	Demchenko, E V: 3 articles (01/2013 - 01/2000)
8.	Shaker, Reza: 3 articles (02/2006 - 07/2003)
9.	Hanson, D G: 3 articles (10/2000 - 03/2000)
10.	Huang, Tao: 2 articles (07/2022 - 01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Laryngitis:

1.	AcidsIBA 03/06/2000 - "Clinical experience and prospective treatment and outcome studies have demonstrated objective evidence of the efficacy of treating patients with chronic laryngitis symptoms with nocturnal antireflux precautions and acid-suppressing medications. " 03/01/2012 - "The aim of this study was to compare the clinical characteristics and response to acid suppression between patients of chronic laryngitis with and without troublesome reflux symptoms. " 06/01/2007 - "Even a recent well-designed large randomized controlled study in laryngitis demonstrated no difference in resolution of symptoms with acid suppression. " 10/01/2005 - "This first preliminary study may suggest that HGMP in the cervical esophagus could play a role in the pathogenesis of LPR, at least in a minor group of patients with posterior laryngitis, depending on its capability to produce acid in situ, although isolated proximal reflux could not be demonstrated. " 07/01/1959 - "[Quantitative histochemical study on the desoxyribonucleic acid of the laryngeal epithelium in chronic aspecific laryngitis]."
2.	SteroidsIBA 04/12/2008 - "Three days earlier she had been diagnosed as having acute laryngitis which was treated with steroids. " 06/01/2002 - "Steroid inhaler laryngitis is a form of chemical laryngopharyngitis induced by topical steroid administration. " 04/01/2014 - "Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation. " 03/01/2002 - "General medical conditions such as gastro-oesophageal reflux and the use of medication such as inhaled steroids are well-recognized causes of laryngitis, but the occupational causes are less well documented. " 12/01/2001 - "(1) Apart from acute laryngitis in children, the use of steroids in acute ENT infections is not supported by clinical data. "
3.	Proton Pump InhibitorsIBA 12/01/2010 - "Fifty-six laryngitis patients were divided into a reflux laryngitis group and a chronic laryngitis group based on the reflux symptom index (RSI), reflux finding score (RFS), and proton pump inhibitor treatment for two weeks. " 04/01/2010 - "This has led us to question if some patients with allergic laryngitis are being misdiagnosed with LPR and thereby being over-treated with proton pump inhibitors (PPIs)." 10/01/2004 - "Treatment with a proton pump inhibitor can be considered as a first-line diagnostic and therapeutic method in patients with idiopathic chronic laryngitis. " 01/01/2002 - "A considerable percentage of patients with reflux laryngitis do not respond to conventional treatment with proton pump inhibitors or prokinetics. " 12/01/2001 - "Proton-pump inhibitors are often recommended in the treatment of laryngitis secondary to gastric reflux. "
4.	Budesonide (Pulmicort)FDA LinkGeneric 01/01/2005 - "The results indicate that nebulised budesonide can be used as a safe and effective alternative treatment in children with moderate to severe subglottic laryngitis." 01/01/2021 - "Efficacy of inhaled budesonide on serum inflammatory factors and quality of life among children with acute infectious laryngitis." 01/01/2021 - "Our study sought to investigate the effect of inhaled budesonide on among children with acute infectious laryngitis. " 09/01/2022 - "A total of 86 patients with acute laryngitis who met the inclusion criteria were randomly assigned according to the random number table method into a Kai Hou Jian treatment group or a budesonide control group. " 12/01/2014 - "[The treatment of acute laryngitis with budesonide]."
5.	GlucocorticoidsIBA 12/22/2001 - "Emergency administration of systemic and inhaled glucocorticoids in the hospital setting is the basic treatment for glotto-subglottic laryngitis. " 03/01/1973 - "[Use of glucocorticoids in acute subchordal laryngitis in children]." 01/07/2018 - "Objective: To evaluate the efficacy of systemic glucocorticoid (steroid) combined with high dose inhaled steroid in the treatment of children with acute laryngitis. " 01/01/2005 - "The aim of this study was to observe efficacy of the treatment of the subglottic laryngitis with glucocorticoids, especially budesonide in nebulization. " 01/07/2018 - "Conclusion: Compared with single systemic glucocorticoid, systemic glucocorticoids combined with inhaled steroid possessed similar efficacy in treating acute laryngitis and relieving laryngeal obstruction of children. "
6.	Omeprazole (Prilosec)FDA LinkGeneric 12/01/2001 - "The objective of this study was to determine the efficacy of omeprazole in treating proven reflux laryngitis. " 05/01/2004 - "Predictors of outcome in an open label, therapeutic trial of high-dose omeprazole in laryngitis." 12/01/1997 - "Empiric trial of high-dose omeprazole in patients with posterior laryngitis: a prospective study." 01/01/2003 - "One hundred out-patients with posterior laryngitis and more than one atypical symptom of LPR, aged 14-68 years were treated with omeprazole for 4 weeks (clinical group). " 01/01/2003 - "Diagnostic test with omeprazole in patients with posterior laryngitis."
7.	Anti-Bacterial Agents (Antibiotics)IBA 03/28/2013 - "Antibiotics appear to have no benefit in treating acute laryngitis. " 03/28/2013 - "Antibiotics for acute laryngitis in adults." 04/18/2007 - "Antibiotics appear to have no benefit in treating acute laryngitis. " 04/18/2007 - "Antibiotics for acute laryngitis in adults." 07/01/2005 - "Antibiotics for acute laryngitis in adults."
8.	ectoineIBA 09/01/2016 - "Taken together, while the tolerability was consistent in both treatment groups, the ectoine-based spray showed superior efficacy in treating acute pharyngitis and/or laryngitis. " 09/01/2016 - "The aim of this observational trial was to evaluate the efficacy and tolerability of a mouth and throat spray containing ectoine in the treatment of acute pharyngitis and/or laryngitis. " 09/01/2016 - "Efficacy and tolerability of an ectoine mouth and throat spray compared with those of saline lozenges in the treatment of acute pharyngitis and/or laryngitis: a prospective, controlled, observational clinical trial." 01/01/2019 - "Pertinent studies published without temporal limitation were selected searching on MEDLINE the following terms: "ectoine" and "nasal spray," "oral spray," "upper respiratory tract infections," "rhinosinusitis," "rhinitis," "rhinoconjunctivitis," "pharyngitis," and "laryngitis." At the end of our selection process, six relevant publications were included: two studies about the effect of ectoine on AR, one study about ARS, one study about rhinitis sicca anterior, and two studies about acute pharyngitis and/or laryngitis. "
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2023 - "Cryptococcal laryngitis in an immunocompetent asthmatic patient using inhaled corticosteroids." 12/01/1993 - "[Corticosteroids and laryngitis?]." 10/14/1990 - "[Subglottic laryngitis treated with corticosteroid inhalation]." 10/31/1965 - "[When to resort to corticoids in acute laryngitis in children]." 05/01/1964 - "[CLINICOSTATISTICAL CONTRIBUTION TO ACUTE STENOSING LARYNGITIS IN INFANTS DURING CORTICOSTEROID TREATMENT]."
10.	Dexamethasone (Maxidex)FDA LinkGeneric 05/01/2001 - "CONCLUSIONS: We did not observe increased efficacy for the treatment of postintubation laryngitis when nebulized L-epinephrine was used simultaneously with intravenous dexamethasone. " 01/01/2021 - "A total of 92 children with acute infectious laryngitis were randomly allocated to either the study (46 cases, treated with inhaled budesonide) and control group (46 cases, treated with dexamethasone). " 12/01/2001 - "(2) A single dose of steroids (oral or intramuscular dexamethasone, 0.6 mg/kg) has only moderate efficacy in children with acute laryngitis, but it can hasten symptom relief. " 05/01/2001 - "OBJECTIVE: To assess the efficacy and safety of the use of nebulized L-epinephrine associated with dexamethasone in postintubation laryngitis. " 02/01/2001 - "Nebulization of solutions associating gomenol, dexamethasone and framycetin is very widespread in otorhinolaryngology (particularly for the treatment of actue laryngitis and post-traumatic laryngitis and rhinitis and for the tracheotomy care). "

Therapies and Procedures

1.	Therapeutics 07/29/2023 - "The use of culture-directed therapy for chronic bacterial laryngitis was helpful in the determination of appropriate treatment in these cases. " 04/05/2013 - "This study suggests that the combined therapy successfully modulated the inflammatory response and collagenization in experimental model of NSGI-induced neurogenic laryngitis." 08/01/2000 - "Patients with a completely normal pH study who are on no medications should be referred back to the ENT physician for further evaluation, as other risk factors for chronic laryngitis such as voice overuse may benefit from concomitant voice therapy. " 06/01/2000 - "This study does not support the decision to treat with anti-secretory therapy, based only on the presence of posterior laryngitis." 08/01/1999 - "The aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. "
2.	Nebulizers and Vaporizers (Inhaler) 01/01/2006 - "As shown by the results of treatment of 48 patients with catarrhal laryngitis, 19 patients with laryngeal angina and 27 patients with phlegmonous laryngitis, nebulizer therapy is highly effective in different forms of laryngeal diseases including purulent process with stenosis." 06/01/2002 - "Steroid inhaler laryngitis is a form of chemical laryngopharyngitis induced by topical steroid administration. " 06/01/2002 - "Patients with steroid inhaler laryngitis were found to have laryngeal findings ranging from mucosal edema, erythema, and thickening to leukoplakia, granulation, and candidiasis. " 01/01/2007 - "Fluticasone ICS were a cause of steroid inhaler laryngitis, and the best treatment was their avoidance or cessation. " 01/01/2006 - "The addition of nebulizer therapy with antiedematous, steroid and mucolytic drugs to antibacterial therapy in patients with different forms of acute laryngitis was assessed. "
3.	Aftercare (After-Treatment) 06/01/2000 - "Posterior laryngitis was not associated with the response to treatment, although there was a trend towards an association between improvement in laryngitis (after treatment) and improvement in symptoms (p = 0.08). " 09/01/2022 - "The change of symptoms scores of acute laryngitis and laryngoscopy scores before and after treatment were performed to value the effect of Kai Hou Jian and the safety was assessed by the patient's discomfort and the incidence and self-reported adverse events during treatment. " 02/01/2022 - "The laryngitis healed immediately after treatment discontinuation, and no recurrence occurred even after resuming intermittent inhalation." 01/01/1879 - "Tracheotomy in Membranous Laryngitis: the indications for its adoption, and some special points as regards its after-treatment." 05/01/2018 - "After treatment, 24.4% of nodules or polyps had decreased in size, 11.1% of patients with chronic laryngitis and postoperative patients had reduced edema, and the mucosal wave of vocal folds had different degrees of recovery in postoperative patients. "
4.	Pain Management 10/01/2018 - "The decoctions of the seeds are used as a remedy for pharyngitis, laryngitis, constipation, cough, menorrhagia, and pain management. "
5.	Respiratory Therapy (Therapy, Respiratory) 01/01/2021 - "A comprehensive treatment scheme for chronic catarrhal laryngitis using inhalation therapy and drugs that improve trophic processes in the laryngeal mucosa, which allows to increase the effectiveness of treatment and achieve stable remission of the disease, is suggested. "