Laryngeal Neoplasms (Laryngeal Cancer)

Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.

Also Known As:

Laryngeal Cancer; Cancer of the Larynx; Laryngeal Neoplasm; Larynx Cancer; Neoplasms, Laryngeal; Cancer, Laryngeal; Cancer, Larynx; Cancers, Laryngeal; Cancers, Larynx; Laryngeal Cancers; Larynx Cancers; Larynx Neoplasm; Neoplasm, Laryngeal; Neoplasm, Larynx; Neoplasms, Larynx; Cancer of Larynx; Larynx Neoplasms

Networked: 3879 relevant articles (146 outcomes, 647 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Neoplasm Metastasis (Metastasis)
4.	Lung Neoplasms (Lung Cancer)
5.	Head and Neck Neoplasms (Head and Neck Cancer)

Experts

1.	Zhou, Liang: 19 articles (02/2022 - 07/2006)
2.	Wolf, Gregory T: 18 articles (01/2022 - 04/2002)
3.	Bradford, Carol R: 16 articles (03/2022 - 04/2002)
4.	Finizia, Caterina: 16 articles (03/2022 - 07/2009)
5.	Pietruszewska, Wioletta: 15 articles (04/2022 - 01/2003)
6.	Klatka, Janusz: 15 articles (01/2022 - 03/2002)
7.	Boffetta, Paolo: 15 articles (01/2020 - 04/2003)
8.	La Vecchia, Carlo: 15 articles (01/2019 - 07/2002)
9.	Eisbruch, Avraham: 14 articles (03/2022 - 08/2002)
10.	Liu, Ming: 14 articles (01/2020 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Laryngeal Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 12/05/2017 - "Conclusion:The cisplatin resistant laryngeal cancer cells perform higherinvasion and migration biological behaviors,and the mechanisms of increased ability of invasion and migration induced by cisplatin was associated to eEMT, study on signal path related to EMT may overcome cisplatin resistance and reduce invasion and migration behaviors." 10/03/2017 - "In the present study, we constantly exposed the laryngeal cancer cell line Hep-2 with cisplatin to establish a cisplatin-resistant laryngeal cancer cell model (Hep-2/R). " 01/01/2016 - "An orthotopic murine study utilizing University of Michigan squamous cell carcinoma-12 (UMSCC-12) laryngeal cancer cells was conducted in randomized controlled fashion with three treatment arms: saline, systemic cisplatin, and peritumoral HA-cisplatin. " 11/01/2012 - "The purposes of this study were to determine whether autophagy was involved in cisplatin (CDDP) resistance and to investigate the role of the autophagy in the regulation of chemosensitivity to CDDP in laryngeal cancer Hep-2 cells. " 01/01/2023 - "The data of 150 patients with oropharynx, hypopharynx, and larynx cancer undergoing curative intensity-modulated RT and weekly cisplatin between April 2015 and December 2019 were retrospectively evaluated. "
2.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/01/2015 - "It was shown that the effective treatment of laryngeal cancer by PDT is possible under condition of the thorough selection of the patients with a definite growth type and localization of the tumour. " 08/01/2014 - "The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer. " 09/01/2007 - "PDT is an effective primary and alternative treatment modality for early oral cavity and laryngeal cancers." 05/01/1995 - "The subjects were 12 patients with laryngeal cancer who underwent PDT between February 1988 and October 1993. " 11/01/2016 - "Photodynamic therapy (PDT) has been developed as a promising treatment modality for laryngeal cancer. "
3.	Docetaxel (Taxotere)FDA Link 06/08/2023 - "Chitosomes Loaded with Docetaxel as a Promising Drug Delivery System to Laryngeal Cancer Cells: An In Vitro Cytotoxic Study." 06/08/2023 - "A higher cytotoxicity (p < 0.05) of docetaxel-loaded chitosomes towards human laryngeal cancer cells was observed compared to human stromal cells and control treatments. " 01/01/2013 - "The HEp2 and docetaxel-resistant HEp2 (HEp-Doc) cell lines were created from human laryngeal cancer. " 09/01/2007 - "A phase I-II study of bi-weekly docetaxel combined with radiation therapy for patients with cancer of the larynx/hypopharynx." 06/08/2023 - "Our in vitro results supported the potential of docetaxel-loaded chitosomes for locoregional chemotherapy delivery to laryngeal cancer cells."
4.	SurvivinIBA 08/01/2010 - "To study the effect of silencing survivin on the growth of Hep-2 human laryngeal cancer cells in vitro and in vivo. " 07/01/2022 - "Furthermore, suppression of Notch1 expression effectively downregulated Notch1 signaling activity and the expression of the MDR and survivin genes in laryngeal cancer cells under hypoxic conditions (P < 0.05). " 01/01/2022 - "In vitro, Ad-ING4-OSM significantly inhibited the growth, enhanced apoptosis, altered cell cycle with G1 and G2/M phase arrest, and upregulated the expression of P21, P27, P53 and downregulated survivin in laryngeal cancer Hep-2 cells. " 08/01/2015 - "Human laryngeal cancer Hep-2 epithelial cells were selected, survivin gene was overexpressed, and cell proliferation was detected by MTT. " 08/01/2015 - "To investigate the mechanism of survivin, p53 and Ki-67 on Hep-2 human laryngeal cancer endothelial cell proliferation and invasion. "
5.	Fluorouracil (Carac)FDA LinkGeneric 05/01/2021 - "The purpose of this study was to investigate the effect of miR-183 on the sensitivity of laryngeal cancer cells to 5-fluorouracil (5-Fu) and its mechanism, so as to provide certain references for the clinical prevention of drug resistance in laryngeal cancer cells. " 10/01/2008 - "Cytotoxicity assay and TUNEL assay were used to assess the effect of 5Fu on laryngeal cancer cells transfected with HPV16 E6 or E7. " 10/01/2008 - "To investigate the cytotoxic effect of 5-fluorouracil (5Fu) on HPV16-associated laryngeal cancer cells. " 01/01/2002 - "Radio-, chemoradiation (with making use of cysplatin and 5-fluorouracil) therapies were employed together with a surgical method as treatment of 197 patients with T1-2N0M0 laryngeal cancer. " 05/01/2021 - "The overexpression of miR-183 can inhibit the drug resistance of the human primary laryngeal cancer cells to 5-Fu, promote cancer cell apoptosis and inhibit their invasive and migratory abilities at the same time, whose mechanism may be associated with the targeted regulation of the TBX3/PTEN signaling pathway by miR-183."
6.	Metronidazole (Metric)FDA LinkGeneric 08/01/1985 - "An analysis of the results showed a significant improvement of the cure rates for laryngeal cancer patients using metronidazole, particularly for those with advanced stages. " 04/01/1989 - "Randomized controlled clinical trial has been carried out in the Oncology Center in Warsaw and Medical Academy in Lódź to assess the effectiveness of application of Metronidazole as radiosensitizer of hypoxic cells in patients with squamous cell laryngeal cancer treated by Cobalt60 irradiation in the years 1982-1986. " 04/01/1989 - "[Comparison of the effectiveness of different methods of irradiation using metronidazole as a radiation-sensitizing agent in patients with laryngeal cancer. " 03/01/1986 - "[Direct and immediate results of the radiation and combined treatment of laryngeal cancer with local use of metronidazole]." 08/01/1985 - "[Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole]."
7.	VaccinesIBA 01/01/2021 - "63.4% of men and 75.4% of women stated that they did not know whether the vaccine was effective against penile, anal and laryngeal cancer. " 07/01/2019 - "Combination of Vaccine Strain Measles Virus and Nimotuzumab in the Treatment of Laryngeal Cancer." 09/01/2009 - "Construction of human full-length survivin gene-modified DCs vaccine and observe the biological characteristics and the role of laryngeal cancer treatment. " 09/01/2009 - "[Human survivin modified DCs vaccine inhibits laryngeal cancer in vivo and in vitro]." 01/01/2015 - "The study focussed on the quadrivalent vaccine which protects against HPV type 6, 11, 16 and 18, and the vaccine's protection against genital warts, cervical intraepithelial neoplasia, cervical cancer, anogenital cancer (anal, penile, vaginal and vulvar cancer) and head and neck cancer (oral cavity, oropharyngeal, hypopharyngeal and laryngeal cancer) were included in the analyses. "
8.	Biomarkers (Surrogate Marker)IBA 11/09/2022 - "From the perspective of lipidomics, this study not only revealed the regulatory changes in the lipid metabolism network, but also provided a new possibility for screening biomarkers in laryngeal cancer." 07/01/2022 - "The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. " 08/01/2021 - "In summary, our study developed a ferroptosis-related model that could be an effective biomarker to predict the prognosis of laryngeal cancer." 10/01/2020 - "The purpose of the present study was to explore the molecular mechanism of the development of laryngeal cancer and to determine the biomarker for the diagnosis and treatment of laryngeal cancer. " 02/01/2020 - "Objective:To study the effect of miR-340-5p on the proliferation of laryngeal cancer Hep2 cells and explore its intrinsic molecular mechanism, so as to screen potential biomarkers and targets for the diagnosis and treatment of laryngeal cancer. "
9.	DNA (Deoxyribonucleic Acid)IBA 06/01/1985 - "The second-passage DNA showed "narrow bands" indicating the possibility that an oncogene has been identified in laryngeal cancer and that serial passage has eliminated contaminating human sequences. " 01/01/2019 - "The review was realized utilizing available studies on the subject of genetic polymorphisms analysis of deoxyribonucleic acid (DNA) samples using polymerase chain reaction (PCR) assays and laryngeal cancer published in the PubMed database. " 01/01/2000 - "The aim of this study was evaluation of DNA ploidy in the cytological samples from patients with laryngeal cancer and comparison a type of DNA ploidy with histological grading (G) and staging of neoplasmatic process. " 01/01/1996 - "Loss of Heterozygosity (LOH) on chromosome 9p21 (D9S319) from fifty-four laryngeal cancer patients has been examined by using the PCR technique of DNA microsatellite markers in this study. " 07/01/1976 - "Comparative microspectrophotometric study of the nuclear Feulgen DNA content in pretumorous processes and cancers (larynx, endometrium, large intestine, and stomach) has made it possible to formulate an exponential law of DNA accumulation in cell populations in proliferating and malignant tissue. "
10.	Small Interfering RNA (siRNA)IBA 08/19/2022 - "Small interfering RNA (siRNA) was used to inhibit Notch1 expression in laryngeal cancer cells. " 01/01/2019 - "GLUT-1 siRNA Enhances Radiosensitization Of Laryngeal Cancer Stem Cells Via Enhanced DNA Damage, Cell Cycle Redistribution, And Promotion Of Apoptosis In Vitro And In Vivo." 01/01/2016 - "The shRNA eukaryotic expression plasmid targeting Livin was successfully constructed, which could significantly inhibit the expression of Livin in laryngeal cancer Hep-2 cells. " 02/20/2015 - "Inhibition of STAT3 activity with a chemical inhibitor or siRNA-mediated depletion of Mcl-1 sensitized radioresistant cells to irradiation, suggesting that the ERp57-STAT3-Mcl-1 axis regulates radioresistance of laryngeal cancer cells. " 01/01/2015 - "To investigate the potential mechanism of EphA7 in human laryngeal cancer, we employed EphA7 siRNA to knockdown EphA7 expression in LSCC cell line Hep-2 and AMC-HN-8. "

Therapies and Procedures

1.	Radiotherapy 02/20/2015 - "Overall, our data suggest that ERp57-STAT3 regulation functions in radioresistance of laryngeal cancer, and targeting the ERp57-STAT3 pathway might be important for enhancing the efficacy of radiotherapy in human laryngeal cancer. " 01/01/2019 - "Radiotherapy does not show good efficacy against laryngeal cancer due to radioresistance. " 01/01/2015 - "Early laryngeal cancer can be successfully treated with surgery or radiation therapy. " 02/01/2002 - "For early-stage laryngeal cancer, both surgery and radiotherapy are effective treatment modalities, offering a high rate of local control and cure for this select group of patients. " 02/01/2001 - "Radiotherapy and surgery for early laryngeal cancer achieve comparably good results in patient survival, and the choice of treatment between them is being influenced increasingly by the expected voice quality and quality of life (QoL). "
2.	Laryngectomy 12/01/2005 - "In the national VA Larynx Cancer Trial, successful organ preservation was associated with an overall improvement in quality of life but not in subjective speech compared with long-term laryngectomy survivors. " 01/01/2016 - "Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension. " 08/01/2011 - "Supracricoid laryngectomy is effective for managing laryngeal cancer. " 07/01/1985 - "It has been well established that supraglottic laryngectomy is an effective treatment of laryngeal cancer arising above the vocal cords with cure rates equaling total laryngectomy. " 07/01/2021 - "The findings from 1109 laryngeal cancer survivors and 154 spouses of total laryngectomy patients helped to identify the barriers and coping mechanism toward psychosocial adjustments. "
3.	Therapeutics 10/01/2013 - "The routine estimation of TV prior to therapy may be essential in order to select the best treatment option for patients with T2 laryngeal cancer." 01/01/2013 - "Thermochemoradiation therapy of locally advanced cancer of the larynx provides a fairly good results comparable with those of the combined treatment." 09/01/1988 - "Control of the hormonal status of laryngeal cancer patients was recommended during therapy with the use of radiomodifying agents to determine the effect of various radiomodifiers on the endocrine system, for the assessment of therapeutic efficacy and, probably, the prediction of the course of the disease." 10/01/2023 - "The principal goal of treatment of laryngeal cancer is to eliminate a tumour while preserving laryngeal function with radio(chemo)therapy being the mainstay of treatment. " 11/01/2020 - "Efficacy of Voice Therapy in Improving Vocal Function in Adults Irradiated for Laryngeal Cancers: A Pilot Study."
4.	Drug Therapy (Chemotherapy) 05/01/2021 - "Drug resistance is one of the main factors limiting the efficacy of chemotherapy in patients with laryngeal cancer; thus, it is important to investigate the drug resistance of laryngeal cancer. " 01/01/1990 - "Preliminary findings indicate that radiation plus chemotherapy is as effective as radiation plus surgery for advanced laryngeal cancer." 04/20/2009 - "Chemotherapy alone in selected patients with T2-4, N0-1 laryngeal cancer can provide durable disease remission at 5 years. " 04/20/2009 - "Durable long-term remission with chemotherapy alone for stage II to IV laryngeal cancer." 03/01/2022 - "Imaging response assessment for predicting outcomes after bioselection chemotherapy in larynx cancer: A secondary analysis of two prospective trials."
5.	Chemoradiotherapy 02/01/2014 - "The University of Michigan has investigated the use of induction selection (IS) with chemoradiotherapy (CRT) for patients who respond to CRT and found this approach effective in the management of advanced laryngeal cancer. " 11/01/2014 - "We analyzed the efficacy of treatments that included alternating chemoradiotherapy in laryngeal cancer patients. " 02/01/2017 - "Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study." 09/01/2008 - "The purpose of this study was to report T4 laryngeal cancer patient outcome, including those with LVT4 disease, treated with chemoradiotherapy. " 09/01/2008 - "Randomized trials established chemoradiotherapy as standard treatment for advanced laryngeal cancer. "