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Laryngeal Neoplasms (Laryngeal Cancer)

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Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.

Also Known As:

Laryngeal Cancer; Cancer of the Larynx; Laryngeal Neoplasm; Larynx Cancer; Neoplasms, Laryngeal; Cancer, Laryngeal; Cancer, Larynx; Cancers, Laryngeal; Cancers, Larynx; Laryngeal Cancers; Larynx Cancers; Larynx Neoplasm; Neoplasm, Laryngeal; Neoplasm, Larynx; Neoplasms, Larynx; Cancer of Larynx; Larynx Neoplasms

Networked: 2301 relevant articles (74 outcomes, 342 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Carcinoma (Carcinomatosis)
3.	Neoplasm Metastasis (Metastasis)
4.	Lung Neoplasms (Lung Cancer)
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma)

Experts

1.	La Vecchia, Carlo: 12 articles (07/2015 - 07/2002)
2.	Boffetta, Paolo: 11 articles (07/2015 - 04/2003)
3.	Klatka, Janusz: 11 articles (10/2013 - 03/2002)
4.	Wolf, Gregory T: 10 articles (01/2014 - 04/2002)
5.	Pietruszewska, Wioletta: 10 articles (09/2012 - 01/2003)
6.	Starska, Katarzyna: 9 articles (11/2015 - 09/2005)
7.	Lewy-Trenda, Iwona: 9 articles (11/2015 - 09/2005)
8.	Levi, Fabio: 9 articles (07/2015 - 07/2002)
9.	Namysłowski, Grzegorz: 9 articles (09/2014 - 01/2003)
10.	Liu, Ming: 9 articles (09/2014 - 01/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Laryngeal Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 07/01/2002 - "PATIENDS AND METHODS: Among the 65 patients receiving concomitant intra-arterial cisplatin and radiation therapy for stage III and IV laryngeal cancer between 1993 and 1999, we identified 45 who were available for follow-up and were disease free 6 months after the completion of therapy. " 11/01/2012 - "The purposes of this study were to determine whether autophagy was involved in cisplatin (CDDP) resistance and to investigate the role of the autophagy in the regulation of chemosensitivity to CDDP in laryngeal cancer Hep-2 cells. " 07/01/2015 - "To interfere the expression of β-catenin can effectively enhance the sensitivity of laryngeal cancer cells to chemotherapeutic drugs cisplatin. " 11/01/2012 - "Inhibition of autophagy-potentiated chemosensitivity to cisplatin in laryngeal cancer Hep-2 cells." 03/01/2009 - "Forty-three patients with advanced laryngeal cancer were treated with 2 courses of intra-arterial cisplatin infusion (100 mg per body) during 40-Gy irradiation. "
2.	Fluorouracil (Carac)FDA LinkGeneric 10/01/2008 - "Cytotoxicity assay and TUNEL assay were used to assess the effect of 5Fu on laryngeal cancer cells transfected with HPV16 E6 or E7. " 10/01/2008 - "To investigate the cytotoxic effect of 5-fluorouracil (5Fu) on HPV16-associated laryngeal cancer cells. " 01/01/2002 - "Radio-, chemoradiation (with making use of cysplatin and 5-fluorouracil) therapies were employed together with a surgical method as treatment of 197 patients with T1-2N0M0 laryngeal cancer. " 10/01/2015 - "In order to treat the primary site without resection, superselective intra-arterial infusions with DCF anterogradely and 60 mg/m2 of DOC and 60 mg/m2 of CDDP via the femoral artery on day 1 were administered, followed by continuous intravenous instillation of 750 mg/m2/day of 5-FU for 5 days from day 2. The 5- year survival rate was 70.4% in laryngeal cancer, 72.8% in oropharyngeal cancer, and 68.5% in hypopharyngeal cancer. " 06/01/1988 - "[Clinical study on the effect of adjuvant immunochemotherapy using OK-432 and 5-FU in pharyngeal and laryngeal cancers]."
3.	Metronidazole (Metric)FDA LinkGeneric 08/01/1985 - "An analysis of the results showed a significant improvement of the cure rates for laryngeal cancer patients using metronidazole, particularly for those with advanced stages. " 04/01/1989 - "Randomized controlled clinical trial has been carried out in the Oncology Center in Warsaw and Medical Academy in Lódź to assess the effectiveness of application of Metronidazole as radiosensitizer of hypoxic cells in patients with squamous cell laryngeal cancer treated by Cobalt60 irradiation in the years 1982-1986. " 04/01/1989 - "[Comparison of the effectiveness of different methods of irradiation using metronidazole as a radiation-sensitizing agent in patients with laryngeal cancer. " 08/01/1985 - "[Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole]." 04/01/1985 - "[The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer]."
4.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 08/01/2014 - "The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer. " 09/01/2007 - "PDT is an effective primary and alternative treatment modality for early oral cavity and laryngeal cancers." 05/01/1995 - "The subjects were 12 patients with laryngeal cancer who underwent PDT between February 1988 and October 1993. " 09/01/2009 - "Photodynamic therapy (PDT) may have an emerging role in the treatment of early laryngeal cancer. " 05/01/2005 - "To investigate the photodynamic therapy (PDT) effect of a new kind of cationic porphyrin on human laryngeal cancer Hep-2 cell in vitro. "
5.	DNA (Deoxyribonucleic Acid)IBA 06/01/1985 - "The second-passage DNA showed "narrow bands" indicating the possibility that an oncogene has been identified in laryngeal cancer and that serial passage has eliminated contaminating human sequences. " 09/30/2010 - "The aim of our study was to evaluate the usefulness and efficiency of FFPE tissues from laryngeal cancer (LSCC) in HPV detection by immunohistochemistry reaction (IHC) and PCR-DNA enzyme immunoassay method (PCR/DEIA) and to compare with HPV detection from DFT. " 01/01/2000 - "The aim of this study was evaluation of DNA ploidy in the cytological samples from patients with laryngeal cancer and comparison a type of DNA ploidy with histological grading (G) and staging of neoplasmatic process. " 07/01/1976 - "Comparative microspectrophotometric study of the nuclear Feulgen DNA content in pretumorous processes and cancers (larynx, endometrium, large intestine, and stomach) has made it possible to formulate an exponential law of DNA accumulation in cell populations in proliferating and malignant tissue. " 01/01/1975 - "[Microspectrophotometric study of the DNA content in the cell nuclei of the mucosal epithelium in precancerous processes and in cell nuclei of the mucosal epithelium in precancerous processes and in cancer of the larynx]."
6.	docetaxel (Taxotere)FDA Link 09/01/2007 - "A phase I-II study of bi-weekly docetaxel combined with radiation therapy for patients with cancer of the larynx/hypopharynx." 01/01/2013 - "The HEp2 and docetaxel-resistant HEp2 (HEp-Doc) cell lines were created from human laryngeal cancer. " 09/01/2007 - "The chemoradiation therapy using bi-weekly docetaxel is an extremely effective treatment for cancer of the larynx/hypopharynx, provided that it is used for the specified stage of cancer." 01/01/2004 - "[A case of pulmonary metastases from laryngeal cancer showing a complete response to chemotherapy with docetaxel]." 06/10/2008 - "To determine whether cucurbitacin B can enhance chemosensitivity to docetaxel in laryngeal cancer, in the present study, we investigated the combined antitumor effect of cucurbitacin B with docetaxel on Hep-2, a human laryngeal cancer cell line. "
7.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 06/01/2002 - "In conclusion, the technical efficacy of 18F-FDG PET in the detection of recurrent laryngeal cancer is high. " 06/01/2002 - "The study is based upon 80 patients, suspected of having recurrent laryngeal cancer, who underwent an 18F-FDG PET study on a coincidence camera and a laryngoscopic biopsy under general anaesthesia. " 06/01/2002 - "In this scenario implementation of 18F-FDG PET scintigraphy in the detection of recurrent laryngeal cancer has additional costs of 64 euro per patient. " 06/01/2002 - "The potential value of 18F-FDG PET in the detection of local relapses of laryngeal cancer after radiotherapy by use of a coincidence camera was prospectively assessed, and a cost-effectiveness analysis was performed retrospectively. " 11/01/1998 - "Fluorine-18-fluorodeoxyglucose (F-18 FDG) PET was used to evaluate early-stage larynx cancer before and after radiotherapy. "
8.	Interleukin-2 (IL2)IBA 01/01/2006 - "The aim of the study was to evaluate the serum level concentration of IL-2 in the laryngeal cancer patients before any medical treatment and its denotation after the surgical procedure. " 01/01/2006 - "The serum concentration of IL-2 in the laryngeal cancer patients treated by surgery is lower than in the healthy control group. " 01/01/2006 - "The serum concentrations of IL-2 in the laryngeal cancer patients were lower than in the control group before the surgical treatment. " 01/01/2006 - "The mean value of IL-2 concentration in laryngeal cancer patients treated by surgery was 23.4 pg/ml before treatment, increased to 37.8 pg/ml in the 1 day and to 54.3 pg/ml 30 days after the therapy. " 01/01/2006 - "[Interleukin 2 concentration changes in the laryngeal cancer patients during the surgical treatment]."
9.	PlatinumIBA 04/20/2009 - "Our objectives were to study the sensitivity of laryngeal cancer to platinum-based chemotherapy alone and to highlight the efficacy of CLS in this setting. " 11/01/1991 - "In this study we analyse our preliminary results after treating 28 patients with locally advanced laryngeal cancer with platinum based induction chemotherapy followed by radiation therapy or surgery. " 05/01/1999 - "In the past 20 years, strategies based on the use of platinum-based induction chemotherapy regimens have been developed in an attempt to preserve the larynx, increase local control, and improve survival in patients with advanced laryngeal cancer. " 11/01/1991 - "Laryngeal preservation in cases of advanced laryngeal cancer treated with platinum based induction chemotherapy before local treatment." 11/01/1991 - "We conclude that although more extensive studies with large groups of patients and longer follow-up is needed to reach definite conclusions, it seems that platinum based induction chemotherapy can be used successfully in locally advanced laryngeal cancer followed by radiotherapy. "
10.	OxygenIBA 04/01/1988 - "Proceeding from an analysis of immediate and short-term results of combined therapy of laryngeal cancer (stage III) patients, the authors compared the efficacy of preoperative irradiation with relation to an oxygen regimen and the level of total focal doses in 3 groups of patients: 23.1 Gy under HBO conditions (the study group), 33 Gy (the 1st control group) and 33 Gy (the 2nd control group) in the air. " 09/01/1985 - "[Preoperative irradiation of laryngeal cancer patients under different oxygen regimens]." 01/01/1984 - "[Morphological changes in laryngeal cancer after preoperative radiation treatment under different oxygen regimens]." 07/01/1987 - "[Functional status of the lymphocytes and adrenal cortex in preoperative radiotherapy of patients with laryngeal cancer exposed to different oxygen conditions]." 07/01/1987 - "The authors presented the results of study of lymphocytic and adrenal cortical function in preoperative radiotherapy of 38 laryngeal cancer patients in different oxygen regimens: in the air and under the conditions of hyperbaric oxygenation (HBO). "

Therapies and Procedures

1.	Radiotherapy 10/01/2010 - "Several clinical trials examining treatment strategies for advanced laryngeal cancer have demonstrated that concurrent chemoradiotherapy is the most effective treatment for improving the patient response to radiotherapy and laryngeal preservation. " 02/20/2015 - "Overall, our data suggest that ERp57-STAT3 regulation functions in radioresistance of laryngeal cancer, and targeting the ERp57-STAT3 pathway might be important for enhancing the efficacy of radiotherapy in human laryngeal cancer. " 02/01/2002 - "For early-stage laryngeal cancer, both surgery and radiotherapy are effective treatment modalities, offering a high rate of local control and cure for this select group of patients. " 02/01/2001 - "Radiotherapy and surgery for early laryngeal cancer achieve comparably good results in patient survival, and the choice of treatment between them is being influenced increasingly by the expected voice quality and quality of life (QoL). " 05/15/1983 - "The results showing a significant improvement in lymph node control with postoperative radiotherapy, this adjuvant therapy is used systematically in this center in patients being operated on for hypopharyngeal and laryngeal cancer with incomplete histologically defined resection and/or with lymph nodes histologically involved."
2.	Laryngectomy 03/01/2008 - "Radiation therapy (RT) is one of the gold standard treatments for early laryngeal cancer, and total laryngectomy is still the most applied surgical procedure after failure. " 12/01/2005 - "In the national VA Larynx Cancer Trial, successful organ preservation was associated with an overall improvement in quality of life but not in subjective speech compared with long-term laryngectomy survivors. " 08/01/2011 - "Supracricoid laryngectomy is effective for managing laryngeal cancer. " 07/01/1985 - "It has been well established that supraglottic laryngectomy is an effective treatment of laryngeal cancer arising above the vocal cords with cure rates equaling total laryngectomy. " 12/01/2006 - "In 1991, a randomized study was published and demonstrated that use of nonsurgical therapy (chemoradiation) provided similar survival to total laryngectomy (the gold standard) for patients with advanced-stage laryngeal cancer. "
3.	Drug Therapy (Chemotherapy) 06/13/1991 - "These preliminary results suggest a new role for chemotherapy in patients with advanced laryngeal cancer and indicate that a treatment strategy involving induction chemotherapy and definitive radiation therapy can be effective in preserving the larynx in a high percentage of patients, without compromising overall survival." 07/01/1998 - "Combined induction chemotherapy and external beam radiation therapy is an effective treatment for selected patients with advanced-stage laryngeal cancer. " 01/01/1990 - "Preliminary findings indicate that radiation plus chemotherapy is as effective as radiation plus surgery for advanced laryngeal cancer." 02/01/2006 - "We conducted a phase II organ preservation trial for patients with stage III and IV larynx cancer to determine whether late salvage surgery rates could be decreased and survival improved by selecting patients for organ preservation based on response to a single cycle of induction chemotherapy. " 04/20/2009 - "Chemotherapy alone in selected patients with T2-4, N0-1 laryngeal cancer can provide durable disease remission at 5 years. "
4.	Neck Dissection (Radical Neck Dissection) 09/01/2005 - "Efficacy of modified radical neck dissection in treatment of laryngeal cancer with node positive neck. " 01/01/1996 - "Efficacy of prophylactic elective neck dissection in the treatment of cancer of the larynx." 01/01/2014 - "The aim of this study was to evaluate the effectiveness of selective neck dissection (SND) in patients with laryngeal cancer and clinically positive cervical nodes. " 01/01/2014 - "The study population consisted of 432 consecutive patients with oral cavity or locally advanced/nonfunctional laryngeal cancer who underwent preoperative CT imaging before initial surgical resection and neck dissection. " 08/01/2012 - "This study aimed to determine whether level I and IIB neck dissection was necessary in patients with laryngeal cancer and clinically detectable or nondetectable neck nodes. "
5.	Lasers (Laser) 05/01/2011 - "Transoral laser microsurgery is a safe and effective initial treatment for early laryngeal cancer, and has high rates of laryngeal preservation and disease-free survival." 05/01/2006 - "We performed laser Doppler fluxmetry on 20 patients with laryngeal cancer and compared the values obtained through this method with manual counting of microvessel density from biopsies, the accepted gold standard. " 05/01/2014 - "The purpose of this study was to assess the feasibility of transoral laser microsurgery (TLM) in treatment of pT3 laryngeal cancer. " 01/01/2014 - "Conclusion This study shows the benefit of the laser endoscopic microsurgery for the preservation of laryngeal functions and the local histologic control, essentially for early stage laryngeal cancers. " 09/01/2013 - "The main objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of T4a laryngeal cancer and to report the oncological and functional outcomes. "