Larva Migrans (Cutaneous Larva Migrans)

Infections caused by nematode larvae which never develop into the adult stage and migrate through various body tissues. They commonly infect the skin, eyes, and viscera in man. Ancylostoma brasiliensis causes cutaneous larva migrans. Toxocara causes visceral larva migrans.

Also Known As:

Networked: 138 relevant articles (21 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Strongyloidiasis
3.	Cutaneous Leishmaniasis
4.	Scabies (Sarcoptic Mange)
5.	Toxocariasis

Experts

1.	Akao, Nobuaki: 4 articles (11/2005 - 04/2005)
2.	Fujita, Koichiro: 3 articles (11/2005 - 04/2005)
3.	Koike, Kazuo: 3 articles (06/2005 - 03/2002)
4.	Nikaido, Tamotsu: 3 articles (06/2005 - 03/2002)
5.	Satou, Tadaaki: 3 articles (06/2005 - 03/2002)
6.	Caumes, Eric: 3 articles (06/2004 - 01/2003)
7.	Vanhaecke, C: 2 articles (05/2014 - 08/2012)
8.	Zibaei, Mohammad: 2 articles (05/2014 - 06/2010)
9.	Sadjjadi, Seyed Mahmoud: 2 articles (05/2014 - 06/2010)
10.	Feldmeier, Hermann: 2 articles (10/2013 - 12/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Larva Migrans:

1.	Albendazole (Albenza)FDA Link 06/01/2012 - "One week of therapy with 400 mg/day oral albendazole is very effective (cure rate: 100%) in patients with cutaneous larva migrans characterized by multiple and/or extensive lesions. " 07/01/1999 - "On the basis of this study, albendazole is effective in cutaneous larva migrans characterized by extensive and/or multiple lesions. " 09/01/1997 - "Albendazole is effective in the treatment of cutaneous larva migrans characterized by multiple and/or diffuse lesions. " 10/01/2008 - "[Case of Toxocara canis larva migrans cured by additional treatment with albendazole]." 06/01/2004 - "Efficacy of albendazole ointment on cutaneous larva migrans in 2 young children."
2.	Ivermectin (Mectizan)FDA Link 08/01/2000 - "The purpose of this prospective study was to update epidemiological data on cutaneous larva migrans (CLM) and to assess the therapeutic efficacy of ivermectin. " 05/01/2014 - "The efficacy of single dose ivermectin in the treatment of hookworm related cutaneous larva migrans varies depending on the clinical presentation." 07/01/1992 - "Efficacy of ivermectin in the therapy of cutaneous larva migrans." 05/01/2014 - "Treatment of hookworm-related cutaneous larva migrans (HrCLM) with a single dose of oral ivermectin has not been adequately evaluated to date. " 12/01/2013 - "Hookworm-related cutaneous larva migrans in patients living in an endemic community in Brazil: immunological patterns before and after ivermectin treatmen."
3.	Thiabendazole (Mintezol)FDA Link 10/01/1999 - "We found topical thiabendazole to be fast and effective in treating this case of cutaneous larva migrans of six months' duration." 07/01/1971 - "[Larva migrans: therapeutic trials with thiabendazole]." 11/01/2001 - "Treatment of widespread cutaneous larva migrans with thiabendazole." 09/01/2000 - "Efficacy and tolerability of thiabendazole in a lipophil vehicle for cutaneous Larva migrans." 12/15/1980 - "Because systemic thiabendazole therapy is frequently associated with toxic side effects, topical application seems to be the treatment of choice for creeping eruption caused by nematodes."
4.	AntigensIBA 10/01/2011 - "Based on these results, the BpRAG1 antigen has a high degree of sensitivity and specificity and should be very useful and reliable in the diagnosis and seroepidemiology of Baylisascaris larva migrans by ELISA." 10/01/2011 - "procyonis antigen, BpRAG1, was reported for use in the development of improved serological assays for the diagnosis of Baylisascaris larva migrans. " 05/01/2014 - "Current results clearly highlight the usefulness of excretory-secretory antigens derived from larvae of Toxocara cati for the fine diagnosis ocular larva migrans caused by Toxocara larvae. " 10/01/2011 - "Recombinant antigen-based enzyme-linked immunosorbent assay for diagnosis of Baylisascaris procyonis larva migrans." 06/01/2010 - "The results indicate that the new antigen detection system provides a useful method for the diagnosis of visceral and ocular larva migrans caused by T. "
5.	NitrogenIBA 11/01/1973 - "[Treatment of creeping disease (larva migrans) with liquid nitrogen]." 05/01/2013 - "Use of liquid nitrogen along with oral anti-helminths is very effective in treating cutaneous larva migrans than Albendazole alone." 05/01/2013 - "To determine the efficacy of combination treatment of Albendazole along with liquid nitrogen in cutaneous larva migrans. " 05/01/2013 - "Use of liquid nitrogen and albendazole in successfully treating cutaneous larva migrans."
6.	Vinyl Chloride (Chloroethylene)IBA 05/01/1951 - "[Case of larva migrans rapidly cured with chloroethylene]."
7.	Promethazine (Promet)FDA LinkGeneric 01/01/1959 - "A new treatment for cutaneous larva migrans; employing oral promethazine."
8.	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 08/01/2009 - "In vitro and in vivo experiments were used to determine whether albendazole-PEG 6000 solid dispersions would be effective in the treatment of Toxocara canis larva migrans. " 08/01/2009 - "High efficacy of albendazole-PEG 6000 in the treatment of Toxocara canis larva migrans infection."
9.	benzimidazoleIBA 01/01/1990 - "We describe the increasing use of a new benzimidazole derivative, albendazole, which is very effective in the treatment of cutaneous larva migrans. "
10.	AntibodiesIBA 12/01/1983 - "canis larvae and in ES, which cross-react with human ABO blood group antibodies must be borne in mind when larvae or their products are used for the serodiagnosis of human toxocaral larva migrans." 04/15/1981 - "Antibodies against larva migrans universalis were identified with the Ouchterlony technique as well as with the microprecipitation test for living toxocara larva twice within a period of 3 years. " 03/01/1980 - "[Titers of antibodies for visceral for larva migrans in hospitalized patients]." 09/01/2004 - "Ocular toxocariasis named also ocular larva migrans is caused by larvae of the roundworm Toxocara spp. The purpose of this study was to find out the seroprevalence of Toxocara antibodies in patients suspected of ocular toxocariasis. " 11/01/2005 - "To confirm the clinical symptoms of visceral larva migrans (VML) and ocular larva migrans (OLM) caused by Toxocara, we administered a questionnaire survey, serological liver function tests, and an ophthalmoscopic examination in 34 subjects having high anti-Toxocara antibodies. "

Therapies and Procedures

1.	Cryotherapy (Therapy, Cold) 03/01/2002 - "Various therapeutic modalities, including cryotherapy, topical and systemic chemotherapy, can be used in the treatment of cutaneous larva migrans. " 09/01/1997 - "Various therapeutic modalities have been used to treat cutaneous larva migrans, including physical treatments (cryotherapy), topical drugs (tiabendazole), and systemic drugs (tiabendazole, albendazole, and ivermectin). "
2.	Microspheres (Microsphere) 08/01/2010 - "In vivo evaluation of albendazole microspheres for the treatment of Toxocara canis larva migrans."
3.	Intradermal Injections 07/01/1955 - "[Larva migrans treated with intradermal injections of chloroquine and emetine]."
4.	Drug Therapy (Chemotherapy) 03/01/2002 - "Various therapeutic modalities, including cryotherapy, topical and systemic chemotherapy, can be used in the treatment of cutaneous larva migrans. "
5.	Cryosurgery 03/01/2002 - "It was demonstrated, that cryosurgery is a fast and effective method in the therapy of cutaneous larva migrans infestation."