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Language Development Disorders (Semantic-Pragmatic Disorder)

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Conditions characterized by language abilities (comprehension and expression of speech and writing) that are below the expected level for a given age, generally in the absence of an intellectual impairment. These conditions may be associated with DEAFNESS; BRAIN DISEASES; MENTAL DISORDERS; or environmental factors.

Also Known As:

Semantic-Pragmatic Disorder; Language Delay; Language Delays; Speech Delay; Auditory Processing Disorder, Central; Central Auditory Processing Disorder; Developmental Disorder, Speech or Language; Developmental Language Disorders; Language Disorders, Developmental; Speech or Language, Developmental Disorder; Delay, Speech; Delays, Speech; Development Disorder, Language; Developmental Language Disorder; Language Development Disorder; Language Disorder, Developmental; Semantic Pragmatic Disorder; Semantic-Pragmatic Disorders; Speech Delays

Networked: 230 relevant articles (3 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Seizures (Seizure)
2.	Hearing Loss (Hearing Impairment)
3.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
4.	Language Development Disorders (Semantic-Pragmatic Disorder)
5.	Dyslexia (Alexia)

Experts

1.	Bellis, Teri James: 5 articles (09/2011 - 12/2005)
2.	Salomons, Gajja S: 4 articles (06/2014 - 09/2005)
3.	Wilson, Wayne J: 4 articles (11/2013 - 01/2003)
4.	Chermak, Gail D: 3 articles (08/2014 - 12/2005)
5.	Jakobs, Cornelis: 3 articles (06/2014 - 09/2005)
6.	Jutras, Benoît: 3 articles (08/2013 - 12/2007)
7.	Ross, Jody: 3 articles (09/2011 - 04/2008)
8.	Cameron, Sharon: 3 articles (02/2009 - 04/2007)
9.	Dillon, Harvey: 3 articles (02/2009 - 04/2007)
10.	Rosenfeld, Jill A: 2 articles (12/2015 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Language Development Disorders:

1.	pamidronate (APD)FDA LinkGeneric 12/01/2012 - "This study investigated whether there are differences in the Speech-Evoked Auditory Brainstem Response among children with Typical Development (TD), (Central) Auditory Processing Disorder (C)APD, and Language Impairment (LI). " 08/01/2010 - "The purpose of this study was to determine the middle latency response (MLR) characteristics (latency and amplitude) in children with (central) auditory processing disorder [(C)APD], categorized as such by their performance on the central auditory test battery, and the effects of these characteristics after auditory training. " 10/01/2014 - "The area of (central) auditory processing disorder [(C)APD] is highly controversial. " 01/01/2014 - "In recent years, there has been a growing interest in Central Auditory Processing Disorder (C)APD. " 01/01/2014 - "Here we focus specifically on how MEG inverse imaging, by providing anatomically based interpretation of neural activity, may allow us to test which aspects of cortical processing play a role in (central) auditory processing disorder [(C)APD]. "
2.	amsonic acid (DAS)IBA 04/01/1997 - "Summed across the three studies, 52% of 48 eligible samples from 53 children with suspected DAS had inappropriate stress, compared to 10% of 71 eligible samples from 73 age-matched children with speech delay of unknown origin. " 04/01/1997 - "Study I compares speech and prosody-voice profiles of a group of 14 children with suspected DAS to profiles of 73 children with speech delay (SD). " 05/01/2015 - "The sensitivity of mild/moderate language delay on the Bayley-III for predicting impairment on DAS-II indices ranged from 40% to 46.7% and specificity ranged from 81.1% to 85.7%. " 12/01/1999 - "The lexical metrical patterns of children with SD-DAS were compared to those of a group of children with speech delay (SD) to verify the applicability of metrical constructs to children with disorders while at the same time seeking lexical stress characteristics that might be useful for differential diagnosis. " 04/01/1997 - "Two prior studies in this series (Shriberg, Aram, & Kwiatkowski, 1997a, 1997b) address the premise that children with developmental apraxia of speech (DAS) can be differentiated from children with speech delay (SD) on the basis of one or more reliable differences in their speech. "
3.	Carbon MonoxideIBA 11/01/2007 - "Half of the children with language delay had problems on Bus Story Test Information and on the Narrative Memory subtest independently of co-occurrence of neuropsychiatric disorder. " 05/01/2007 - "Young children who are in early intervention programmes for speech/language delays may have significant co-ordination difficulties that will become more evident at kindergarten age when motor deficits begin to impact self-care and academic tasks. " 07/01/2004 - "Results suggest that co-occurrence of attention-behavioural, motor-perceptual, and language delays occurring in school-aged children could already be detected at the age of 4 years. " 01/01/2000 - "There is a challenge to the view that disorders in the semantic and pragmatic domains necessarily co-occur, as suggested by the diagnostic category semantic-pragmatic disorder." 12/01/1982 - "Two types of interactions are examined: The co-occurrence of speech and language delay and the effects of phonological reduction on the realization of phonetically complex morphophonemes. "
4.	Temazepam (Nocturne)FDA LinkGeneric 11/01/1989 - "Results of CT/MRI studies suggest that in the brains of dyslexics there is an increased incidence of symmetry in the region of the planum temporale and parietooccipital cortex that may be associated with language delay and handedness. " 09/01/1998 - "Using high-resolution magnetic resonance morphometry, we studied 21 right-handed children with developmental language disorder of the phonologic-syntactic type, and found normal left-right asymmetry of the planum temporale and planum parietale when compared with 21 matched controls. " 12/01/1997 - "Brain morphology studies of individuals with developmental language disorders report reversed asymmetry or symmetry of the planum, although the bulk of this research has been completed on adults with dyslexia. "
5.	Triple X syndromeIBA 11/01/2014 - "The most strongly affected brain regions are consistent with phenotypic characteristics such as language delay, poor executive function and heightened anxiety previously described in population-based studies of Trisomy X and also found in our sample." 01/01/2010 - "Children with trisomy X have higher rates of motor and speech delays, with an increased risk of cognitive deficits and learning disabilities in the school-age years. " 06/01/2012 - "Triple X syndrome is a sex chromosomal aneuploidy condition characterized by tall stature, microcephaly, hypertelorism, congenital abnormalities, and motor and language delays. "
6.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 06/01/2015 - "Although language development as reported by the mothers was found to be poorer than expected in the rTMS-treated group, the delay was found to be similar to the language delay observed in offspring of untreated mothers, as reported in previous studies of prenatal depression treated with selective serotonin reuptake inhibitors."
7.	Methylphenidate (Ritalin)FDA LinkGeneric 08/01/2000 - "A double-blind, placebo-controlled study was used to investigate the effects of methylphenidate (Ritalin) on tests of auditory processing in children diagnosed with both Attention Deficit Hyperactivity Disorder (ADHD) and Central Auditory Processing Disorder (CAPD). "
8.	Levodopa (L Dopa)FDA LinkGeneric 01/01/2012 - "She had language delay, severe hypotonia and abnormal eye movements and responded dramatically to a trial of levodopa (4 mg/kg per day). "
9.	Glucose (Dextrose)FDA LinkGeneric 06/30/2007 - "To investigate the general characteristics of glucose metabolism distribution and the functional deficit in the brain of children with developmental language delay (DLD), we compared functional neuroradiological studies such as positron emission tomography (PET) of a patient group of DLD children and a control group of attention- deficit hyperactivity disorder (ADHD) children. "
10.	ruberythric acid (AlP)IBA 02/01/2010 - "The study group (Group 1) was consisted of 12 ALP children (8 males and 4 females), aged 5-10 years, and associated with receptive and expressive language delay. "

Therapies and Procedures

1.	Cochlear Implants (Cochlear Implant) 05/01/2013 - "A growing number of studies on deaf children with cochlear implant (CI) document a significant improvement in receptive and expressive language skills after implantation, even if they show language delay when compared with normal-hearing peers. " 01/01/2015 - "This study investigated if a period of auditory sensory deprivation followed by degraded auditory input and related language delays affects visual concept formation skills in long-term prelingually deaf cochlear implant (CI) users. " 04/01/2013 - "The children who received their cochlear implant between 13 and 24 months demonstrated a significant language delay at 3 years postimplant. "
2.	Middle Ear Ventilation (Tympanostomy) 12/01/1999 - "Many children had speech and language delay, but parents thought this improved after grommet insertion. " 01/01/1992 - "Referral for insertion of tympanostomy tubes is most appropriate for patients with documented language delay and/or significant medical complications." 05/01/2004 - "The subcommittee also made recommendations that (4) hearing testing be conducted when OME persists for 3 months or longer, or at any time that language delay, learning problems, or a significant hearing loss is suspected in a child with OME; (5) children with persistent OME who are not at risk should be reexamined at 3- to 6-month intervals until the effusion is no longer present, significant hearing loss is identified, or structural abnormalities of the eardrum or middle ear are suspected; and (6) when a child becomes a surgical candidate, tympanostomy tube insertion is the preferred initial procedure. " 05/01/2004 - "The subcommittee also made recommendations that 4) hearing testing be conducted when OME persists for 3 months or longer or at any time that language delay, learning problems, or a significant hearing loss is suspected in a child with OME, 5) children with persistent OME who are not at risk should be reexamined at 3- to 6-month intervals until the effusion is no longer present, significant hearing loss is identified, or structural abnormalities of the eardrum or middle ear are suspected, and 6) when a child becomes a surgical candidate (tympanostomy tube insertion is the preferred initial procedure). "
3.	Hemispherectomy 07/01/1998 - "Continuous unilateral epileptiform discharge and language delay: effect of functional hemispherectomy on language acquisition." 07/01/1998 - "To assess the efficacy of functional hemispherectomy in promoting language acquisition in a child with severe language delay and continuous left hemispheric epileptiform discharge in the absence of clinical seizures. "
4.	Continuous Ambulatory Peritoneal Dialysis (CAPD) 03/01/2015 - "The aim of this study is to compare central auditory processing disorder (CAPD) profile between children born prematurely and at term. " 09/01/2008 - "To study MMN in patients with Central Auditory Processing Disorder - CAPD. " 06/01/1997 - "The purpose of this study was to determine if there were differences between children identified in a clinical setting as having Central Auditory Processing Disorder (CAPD), an age-matched peer group, and young adults when tested using a vocal reaction time (VRT) format. " 07/01/2015 - "Although central auditory processing disorder (CAPD) test battery performance has been examined in adults with neurologic lesions of the central auditory nervous system (CANS), similar data on children being referred for CAPD evaluations are sparse. " 06/01/2015 - "The purpose of this article is to review the literature that pertains to ongoing concerns regarding the central auditory processing construct among school-aged children and to assess whether the degree of uncertainty surrounding central auditory processing disorder (CAPD) warrants a change in current protocols. "
5.	Language Therapy (Language Training) 07/01/2003 - "The study reports data on 69 children under the age of 3.5 years who were referred for speech and language therapy because of early speech and language delay. " 01/01/2003 - "The review considered randomised controlled trials of speech and language therapy interventions for children or adolescents with primary speech and language delay/disorder. " 11/01/2002 - "The paper presents a research study investigating the effectiveness and acceptability of community speech and language therapy provision for preschool children with early speech/language delays. " 04/01/2001 - "The model suggests that most of the children in the study will reach a level of over 90% sentence recognition in the auditory-visual condition when their language becomes equivalent to that of a normally hearing 7-year-old, but they will enter secondary school at age 12 with an average language delay of about 4 or 5 years unless they receive concentrated and effective language training." 09/01/2014 - "Expressive language delay was detected at 12 months and treated with speech and/or language therapy. "