Laminectomy

A surgical procedure that entails removing all (laminectomy) or part (laminotomy) of selected vertebral lamina to relieve pressure on the SPINAL CORD and/or SPINAL NERVE ROOTS. Vertebral lamina is the thin flattened posterior wall of vertebral arch that forms the vertebral foramen through which pass the spinal cord and nerve roots.

Also Known As:

Networked: 5328 relevant articles (336 outcomes, 477 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Cuzzocrea, Salvatore: 38 articles (01/2019 - 10/2004)
2.	Epstein, Nancy E: 37 articles (01/2022 - 04/2002)
3.	Mazzon, Emanuela: 34 articles (01/2015 - 02/2005)
4.	Bramanti, Placido: 31 articles (01/2015 - 02/2005)
5.	Di Paola, Rosanna: 29 articles (01/2014 - 10/2004)
6.	Esposito, Emanuela: 27 articles (01/2014 - 07/2006)
7.	Genovese, Tiziana: 26 articles (08/2011 - 10/2004)
8.	Bydon, Ali: 23 articles (01/2020 - 01/2008)
9.	Sun, Yu: 21 articles (01/2022 - 09/2008)
10.	Shiraishi, Tateru: 18 articles (10/2022 - 03/2002)

Related Diseases

1.	Pain (Aches) 05/01/1989 - "It is clear that for the patient with acute disc displacement with leg-pain as the predominant symptom, simple laminectomy and disc excision will yield good results in most cases. " 03/01/1979 - "Laminectomy is most effective for pain secondary to direct compression of the neural elements. " 01/01/2022 - "The patient was successfully reimplanted with a Nalu micro-implantable pulse generator for SCS therapy with 75% improvement in her post-laminectomy pain complaints with no complaints of pocket pain." 05/14/2020 - "Based on these results, we diagnosed cervical spinal cord compression and underwent laminoplasty at C4-6 including dome-like laminectomy, which significantly relieved the thigh pain and enabled her to walk for 40 minutes. " 04/01/2019 - "Among MC Type I, PSF compared to laminectomy had significantly more improvement in pain VAS (P = 0.01), but the changes in modic Type II were similar between groups (P = 0.89). "
2.	Spinal Cord Diseases 10/25/2019 - "Although microendoscopic partial laminectomy for patients with degenerative cervical myelopathy (DCM) has been reported and demonstrated good results, a detailed comparison of its mid-term surgical results with those of laminoplasty (LP) has not been reported. " 01/01/2015 - "This is a commentary on the article laminoplasty versus laminectomy and fusion (LF) for multilevel cervical myelopathy: A meta-analysis of clinical and radiological outcomes by Chang-Hyun Lee et al. Here, the authors utilized seven studies to compare the efficacy of cervical expansive laminoplasty (EL) versus laminectomy and fusion (LF) to address three or more level multilevel cervical spondylotic myelopathy (CSM). " 01/01/2019 - "Decompressive laminectomy for poor grade myelopathy is effective in improving functional outcome." 09/01/2018 - "We aimed to investigate the effect of intramedullary signal intensity in MRI on the therapeutic efficacy of posterior cervical decompression laminectomy with fixation for multi-level cervical spondylotic myelopathy. " 09/01/2018 - "The effect of intramedullary signal intensity in MRI on the therapeutic efficacy of posterior cervical decompression laminectomy with internal fixation and fusion for multi-level cervical spondylotic myelopathy : a retrospective cohort study."
3.	Pathologic Constriction (Stenosis) 08/01/2005 - "Bilateral and unilateral laminotomy allowed adequate and safe decompression of lumbar stenosis, resulted in a highly significant reduction of symptoms and disability, and improved health-related quality of life. " 10/01/2007 - "In Tema, decompressive lumbar laminectomy for lumbar stenosis achieves significant clinical improvement with attendant low morbidity and mortality rates in patients who have failed conservative treatment. " 02/15/2002 - "Microendoscopic laminotomy can be used to decompress the spinal canal as effectively as an open laminotomy and may prove to be beneficial in decreasing the complications and morbidity of standard treatments for lumbar stenosis." 01/01/2022 - "Several studies have shown that both microscopic unilateral laminotomy bilateral decompression (ULBD) and unilateral biportal endoscopic (UBE) ULBD are effective for treating lumbar canal stenosis (LCS). " 09/01/2021 - "The less-invasive technique appears to be as effective for lumbar stenosis as the traditional lumbar laminectomy. "
4.	Spinal Stenosis (Stenosis, Spinal) 07/01/2010 - "CONCLUSIONS Lumbar laminectomy appears to be the most cost-effective treatment strategy for patients with symptomatic lumbar spinal stenosis." 01/01/2022 - "For example, in a randomized trial of 94 participants with symptomatic and radiographic degenerative lumbar spinal stenosis, decompressive laminectomy improved symptoms more than nonoperative therapy (difference, 7.8 points; 95% CI, 0.8-14.9; minimum clinically important difference, 10-12.8) on the Oswestry Disability Index (score range, 0-100). " 02/25/2020 - "Objective: To evaluate the safety and efficacy of the combined use of ultrasonic bone curette with the high-speed drill in posterior laminectomy and decompression procedure for severe thoracic spinal stenosis, and propose the optimal cutting position for ultrasonic bone curette during the laminectomy. " 11/01/2018 - "Lumbar spinous process-splitting laminectomy led to significant improvement with respect to patient-reported perceived recovery, functional disability and radiological evidence of effective surgical decompression in patients with lumbar spinal stenosis.." 05/01/2013 - "There is significant clinical improvement after laminectomy and dynamic stabilization with Dynesys for lumbar spinal stenosis. "
5.	Fibrosis (Cirrhosis) 11/01/2014 - "The results of our study demonstrate that PLGA/CS barrier is effective in inhibiting epidural fibrosis and peridural adhesions in post-laminectomy rabbit model." 01/01/2021 - "The rESWT application immediately after surgery is effective in preventing epidural fibrosis after laminectomy in rats." 01/01/1998 - "The study population was culled from a randomized, multicenter clinical trial designed to evaluate the efficacy of a device inhibiting postoperative epidural fibrosis after single-level, unilateral laminectomy/diskectomy for herniated lumbar disk. " 01/01/2014 - "Further investigations under the light of these findings may help to reduce epidural fibrosis formation after laminectomy." 10/01/2023 - "This study allows a comprehensive review of pharmacotherapies to prevent epidural fibrosis during laminectomy. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Hyaluronic Acid (Hyaluronan)
3.	Steroids
4.	Bupivacaine (Bupivacaine Hydrochloride)
5.	Mitomycin (Mitomycin-C)
6.	Etanercept (Enbrel)
7.	Collagen
8.	Elements
9.	Tranexamic Acid (AMCA)
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Decompression
2.	Laminoplasty
3.	Diskectomy (Discectomy)
4.	Laminectomy
5.	Therapeutics