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Lactoylglutathione Lyase

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An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.

Also Known As:

Glutathione Lyase, Lactoyl; I, Glyoxalase; Lyase, Lactoyl Glutathione; Lyase, Lactoylglutathione; Glyoxalase I; Lactoyl Glutathione Lyase; Methylglyoxalase; S-Lactoyl-glutathione methylglyoxal-lyase (isomerizing)

Networked: 123 relevant articles (3 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Lyases: 25
    - Carbon-Sulfur Lyases
      - Lactoylglutathione Lyase: 123

Experts

1.	Kalousová, Marta: 4 articles (03/2015 - 04/2008)
2.	Jáchymová, Marie: 4 articles (03/2015 - 04/2008)
3.	Antognelli, C: 3 articles (04/2015 - 09/2002)
4.	Schalkwijk, Casper G: 3 articles (04/2014 - 01/2011)
5.	Zhang, Zhenbo: 3 articles (04/2013 - 02/2011)
6.	Zhu, Yaping: 3 articles (04/2013 - 02/2011)
7.	Feng, Youji: 3 articles (04/2013 - 02/2011)
8.	Dong, Lingling: 3 articles (04/2013 - 02/2011)
9.	Antognelli, Cinzia: 3 articles (01/2013 - 03/2006)
10.	Miyata, Toshio: 3 articles (01/2013 - 04/2009)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1995 - "Thus increased glyoxalase I is associated with the malignant phenotype and may also contribute to protection against the cytotoxicity of certain anti-cancer drugs." 02/26/2015 - "Among these six candidates, GLO1, encoding a detoxifying enzyme glyoxalase I (GLO1), exhibited the strongest tumor-forming activity. " 01/01/2014 - "Glyoxalase I in tumor cell proliferation and survival and as a potential target for anticancer therapy." 02/01/2011 - "Several recent developments suggest that the human glyoxalase I (GLO I) is a potential target for anti-tumor drug development. " 03/01/2005 - "Glyoxalase I activity has been shown to be directly related to cancer and its inhibitors have been used as anti-cancer drugs. "
2.	Reperfusion Injury 04/01/2009 - "Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats."
3.	Adenoma (Adenomas) 01/21/2011 - "A significant reduction in both Glyoxalase I and FN3K activity was detected in patients with tumors compared to patients with adenomas and the controls. " 01/21/2011 - "Erythrocyte Glyoxalase I activity in colorectal cancer was approximately 6 times lower than that detected in patients with adenoma (0.022 ± 0.01 mmol/min per milliliter vs 0.128 ± 0.19 mmol/min per milliliter of red blood cells, P = 0.003, Tukey's test). " 01/21/2011 - "To investigate Glyoxalase I and fructosamine-3-kinase (FN3K) activity in red blood cells from patients with colorectal adenomas and cancer. "
4.	Carcinoma (Carcinomatosis) 12/01/2003 - "Glyoxalase I-mediated drug resistance was found in human leukaemia and lung carcinoma cells. " 01/01/2001 - "Glyoxalase I phenotype as a potential risk factor for prostate carcinoma." 03/15/1993 - "These results suggest induction of the glyoxalase-I gene expression in colon carcinomas." 03/15/1993 - "Examination of colon carcinomas for the amplification of the glyoxalase-I gene by Southern blot analysis revealed no change in gene copy number. " 03/15/1993 - "Northern analysis of the RNA showed an approximately 12-fold increase of the 2.2-kilobase glyoxalase-I transcript in carcinoma when compared to normal colon tissue from the same patient. "
5.	Genetic Predisposition to Disease (Genetic Predisposition) 04/01/2008 - "In summary, in this study we demonstrate for the first time the association of A419C polymorphism of the glyoxalase I gene with sRAGE levels and show the genetic predisposition to vascular complications in HD patients." 04/27/2005 - "The same phenotype-dependent difference was found in red blood cells with NAB-M and CM-M animals showing intermediate expression profiles of glyoxalase-I. Additional studies will examine whether glyoxalase-I has an impact beyond that of a biomarker to predict the genetic predisposition to anxiety- and depression-like behavior." 07/01/1993 - "With the purpose to study the genetic susceptibility to paracoccidioidomycosis infection we searched for a possible association between glyoxalase I and the intradermic paracoccidioidin reaction. "

Related Drugs and Biologics

1.	hydroxyacylglutathione hydrolase
2.	Enzymes
3.	Messenger RNA (mRNA)
4.	Pyruvaldehyde (Methylglyoxal)
5.	Advanced Glycosylation End Products
6.	Metformin (Glucophage)
7.	Aldehyde Reductase (Aldose Reductase)
8.	Complement System Proteins (Complement)
9.	Pepsinogen A (Pepsinogen)
10.	Steroid 21-Hydroxylase (21 Hydroxylase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Lenses