Lactones

09/01/2008 - "Prepared NPs described here were considered potentially useful in both stabilizing and delivering 9-NC and enhancing the efficacy of this drug for cancer treatment for which high drug retention in the body, protection from the drug-active lactone form, and gradual drug release appeared to be related."
01/01/2000 - "The potential merits of the formulation were demonstrated by its profoundly improved lactone stability in vivo, favorable pharmacokinetic and biodistribution characteristics in rats, and enhanced preclinical efficacy in tumor-bearing athymic mice."
08/05/2019 - "Hence, this lactone could be considered a molecule worthy of study as an anti-tumor agent with therapeutic potential."
10/15/2016 - "In this study, we developed polymeric nanoparticles (NPs) that not only deliver IRT to tumor sites, but also overcome its drawbacks by preserving active lactone conformation, prolonging the plasma circulation time, and by providing sustained release. "
09/01/2014 - "Therefore, our data indicate new directions for the further studies of the pathways engaged in the anticancer action exerted by α-methylene-δ-lactones in cancer cells. "

10/12/2015 - "After 2005, outbreaks reported at the eastern shore as well as for new infections in other areas of high infection frequency were considered to possibly be related to reduced efficacy of macrocyclic lactones. "
01/01/2016 - "Effective prevention of the disease is mainly by the use of the macrocyclic lactone class of drugs as heartworm preventives, and no other class of drugs is effective for preventing infection. "
04/01/2014 - "A β-lactone-based antivirulence drug ameliorates Staphylococcus aureus skin infections in mice."
12/01/2016 - "This study assayed the biological properties of a synthetic GM-3 lactone mimetic, 1, aimed at blocking HIV-1 infection without inducing the adverse events expected by an altered metabolism of GLSs in vivo. "
01/01/2023 - "The development of parasites resistant to macrocyclic lactones (ML) has created a significant challenge to the control of the infection. "

01/01/2013 - "We have used heterologous expression to explore the lactone sensitivity of AgOr48, an odorant-sensitive OR from the principal malaria vector mosquito, Anopheles gambiae. "
02/01/2021 - "These lactones have been applied successfully on malaria therapy for decades. "
02/01/2004 - "Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum."
03/01/2002 - "Since this plant is used against malaria and other diseases in the Guatemalan folk medicine, the main sesquiterpene lactones were tested for their activities against Plasmodium falciparum in vitro."
11/01/2019 - "The plant has been used in Ayurveda and traditionally used to treat malaria and cancer, and possesses several sesquiterpene lactones. "

03/01/2018 - "Dietary intake of glucono-δ-lactone attenuates skin inflammation and contributes to maintaining skin condition."
01/01/2013 - "Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-κB signaling. "
12/01/2020 - "This bioactive steroidal lactone possesses multiple functions such as anti-oxidation, anti-inflammation, and immunomodulation. "
01/01/2020 - "This review focuses on sesquiterpene lactones, a class of natural compounds, that represents a future promise in the treatment of inflammation. "
10/01/2004 - "In this study, the anti-inflammatory and anti-hyperalgesic effects of these isolated lactones from these two plant sources were evaluated in the rat carrageenan inflammation model. "

05/01/2022 - "The sesquiterpene lactones including five major constituents may be the main anti-asthma active constituent of X. sibiricum. "
05/01/2022 - "We explore whether sesquiterpene lactones from X. sibiricum (SL-XS) is the main active constitute for its anti-asthma activity. "
05/01/2022 - "Sesquiterpene lactones from Xanthium sibiricum Patrin alleviate asthma by modulating the Th1/Th2 balance in a murine model."
04/01/2023 - "Our previous studies found that sesquiterpene lactones, the main bioactive constituents of X. sibiricum, relieved airway inflammation in an asthma mouse model. "
03/01/2018 - "In addition, a murine ovalbumin-induced allergic asthma model was used to test the in vivo efficacy of sesquiterpene lactones. "