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Labetalol (Normodyne)

A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.

Also Known As:

Normodyne; Trandate; AH-5158; Albetol; Alphapharm Brand of Labetalol Hydrochloride; Apo-Labetalol; Apotex Brand of Labetalol Hydrochloride; Celltech Brand of Labetalol Hydrochloride; Dilevalol; Faro Brand of Labetalol Hydrochloride; Glaxo Wellcome Brand of Labetalol Hydrochloride; GlaxoSmithKline Brand of Labetalol Hydrochloride; Kern Brand of Labetalol Hydrochloride; Labetalol Hydrochloride; Labetalol, (R,R)-Isomer; Labetolol; Leiras Brand of Labetalol Hydrochloride; Presolol; R,R-Labetalol; SCH-19927; Schering Brand of Labetalol Hydrochloride; Shire Brand of Labetalol Hydrochloride; Sigma Brand of Labetalol Hydrochloride; AH 5158; AH5158; Apo Labetalol; ApoLabetalol; Hydrochloride, Labetalol; R,R Labetalol; SCH 19927; SCH19927; Benzamide, 2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-

Networked: 865 relevant articles (79 outcomes, 130 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58

Experts

1.	Peacock, W Frank: 7 articles (03/2015 - 08/2009)
2.	Magee, L A: 6 articles (01/2016 - 01/2000)
3.	von Dadelszen, Peter: 5 articles (03/2015 - 10/2003)
4.	Magee, Laura A: 5 articles (03/2015 - 10/2003)
5.	Chandra, Abhinav: 4 articles (03/2015 - 01/2011)
6.	Varon, Joseph: 4 articles (07/2014 - 01/2011)
7.	Kaminski, Brian: 3 articles (07/2014 - 01/2011)
8.	Baumann, Brigitte M: 3 articles (07/2014 - 01/2011)
9.	Hiestand, Brian: 3 articles (07/2014 - 01/2011)
10.	Cannon, Chad M: 3 articles (07/2014 - 01/2011)

Related Diseases

1.	Hypertension (High Blood Pressure) 12/01/1989 - "Dilevalol appears to be a safe and effective drug that can be used intravenously successfully in the majority of patients with severe hypertension and provides an alternative to therapy with other agents. " 06/01/1982 - "1 Labetalol 100 mg was given intravenously to 27 patients with essential hypertension (12 males, 15 females; WHO I-II; age range 30-66 yr; on average, a significant reduction of blood pressure was observed within 5 min (P less than 0.001). " 01/01/1980 - "In 17 patients with essential hypertension administration of labetalol alone resulted in a significant reduction in supine systolic and diastolic blood pressure of 14% and 17%, respectively. " 01/01/1977 - "It is suggested that the efficacy of oral labetalol merits further investigation in the rapid control of severe hypertension." 05/01/1992 - "It is concluded that dilevalol is effective in the treatment of hypertension and that DPG is a sensitive noninvasive method to measure vasodilatation."
2.	Hypotension (Low Blood Pressure) 01/01/1989 - "In order to study the influence of labetalol on the peroperative oxygenation during deliberate hypotension, 50 patients undergoing middle ear microsurgery were randomly divided in two groups of 25 patients; one group receiving labetalol to induce hypotension, the other group receiving placebo in a double blind manner. " 07/01/2012 - "Hypotension is more common after maternal labetalol exposure, regardless of the dosage and route of administration. " 07/01/2012 - "In a multivariate regression model, labetalol exposure, the need for intubation and PDA appeared independently associated with hypotension (P<0.001). " 07/01/2012 - "Hypotension occurred significantly more in conjunction with labetalol exposure (16, (29.1%) vs. 4 (7.4%); p=0.003), irrespective of the route of administration. " 07/01/2006 - "We present a case of profound hypotension, refractory to inotropic and vasopressor therapy following an iv infusion of labetalol. "
3.	Angina Pectoris 01/15/1983 - "In comparison with placebo, labetalol significantly reduced the frequency and severity of attacks of angina pectoris, without further improvement in control of blood pressure at rest, during isotonic exercise or on performance of the cold pressor test. " 01/01/1985 - "The efficacy of labetalol, an alpha and beta receptor antagonist, was evaluated in 12 normotensive patients with stable angina pectoris in a single blind dose ranging study. " 09/01/1988 - "There are very few studies investigating the effects of labetalol in normotensive patients with angina pectoris. " 03/01/1985 - "[Trial of labetalol in effort angina pectoris]." 01/01/1993 - "Labetalol was the first combined-action beta-blocking drug to be described and was shown to be capable of increasing exercise tolerance in patients with angina pectoris. "
4.	Tachycardia (Tachyarrhythmias) 01/01/1983 - "These results were confirmed by a clinical study where in a series of 110 CAD patients 21 were treated during the surgical procedure with incremental doses of Labetalol to control high systolic blood pressure and tachycardia. " 09/01/1998 - "Labetalol therapy resulted in a decrease in maternal pulse and blood pressure, and resolution of fetal tachycardia. " 06/01/1990 - "Oral dilevalol 200 mg reduces an exercise tachycardia by about 25% and 400 mg does not increase the effect. " 09/01/1988 - "During exercise, tachycardia was blunted (-12% after intravenous, -7% after oral labetalol, both p less than 0.05) as was the increase in mean aortic pressure (-12% and -13% intravenous and oral labetalol respectively, both p less than 0.05), left ventricular end-diastolic pressure [-7% and -1%, respectively, both p = not significant (NS)] was unchanged. " 06/01/1987 - "Labetalol produced a prompt but smooth reduction in BP without any reflex tachycardia or other adverse effects. "
5.	Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced) 01/01/1989 - "Labetalol appears to be an effective agent in the management of mild to moderate pregnancy-induced hypertension. " 12/01/1992 - "To determine the need for, and efficacy of, treatment with labetalol in women with mild-to-moderate pregnancy induced hypertension (PIH). " 12/01/1992 - "Anti-hypertensive intervention therapy in pregnancy induced hypertension has been examined using a placebo controlled randomised double-blind trial of labetalol in pregnancy. " 12/01/1992 - "A randomised placebo controlled trial of labetalol in the treatment of mild to moderate pregnancy induced hypertension." 01/01/1989 - "The fetal outcome in a randomized double-blind controlled trial of labetalol versus placebo in pregnancy-induced hypertension."

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Related Therapies and Procedures

1.	Anesthesia
2.	Injections
3.	Cesarean Section (Caesarean Section)
4.	Intravenous Infusions
5.	Intravenous Injections