Kynurenine

03/01/1994 - "In the present study, L-kynurenine and QUIN concentrations in both cerebrospinal fluid (CSF) and serum were reduced in patients with intractable complex partial seizures (CPS) in both the postictal period (15-75 min after a seizure) and the interictal period (absence of seizure for > 24 h) as compared with neurologically normal control subjects. "
03/01/1998 - "Blockade of GAMAB-receptors and weakening of dopaminergic activity are important in the mechanisms of kynurenine convulsions, and blockage of GABAA-receptors unrelated to it is important in the mechanisms of corasole convulsions. "
09/01/1995 - "These results suggest that the presence of seizures in WS is associated with altered kynurenine metabolism. "
03/01/1994 - "Kynurenine pathway metabolites in cerebrospinal fluid and serum in complex partial seizures."
02/01/1994 - "The possibility that seizures may be related to increased or decreased production of certain kynurenine metabolites is discussed."

09/01/2009 - "Our study demonstrated that kynurenine metabolites and increased oxidative status are independently and significantly associated with endothelial dysfunction in ESRD patients."
03/01/2002 - "The aim of the present study was to examine the time-course of changes in the peripheral kynurenine products degradation during experimental chronic renal failure in rats. "
09/01/2009 - "TM and vWF were positively associated with kynurenine pathway metabolites: KYN, 3-HKYN, QA (all p<0.001), and with SOX markers: Cu/Zn SOD (both p<0.0001) and MDA levels (p<0.05, and p<0.0001; respectively) in the whole ESRD group. "
06/01/2003 - "We conclude that chronic renal failure is associated with the accumulation of L-kynurenine metabolites, which may be involved in the pathogenesis of certain uremic syndromes."
01/01/2003 - "It has been suggested that kynurenine pathway may be an important pathological factor during the chronic renal failure (CRF) development. "

01/01/1983 - "Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy."
12/01/2013 - "The kynurenine pathway as a potential drug target for the treatment of epilepsy."
05/01/2011 - "Kynurenine (kyn)/trp serum ratio, as an indicator of IDO activity was analyzed in 271 carefully classified epilepsy patients, and 309 healthy adults. "
01/01/2011 - "The KYNA ratios are defined as the ratio of neuroprotective KYNA versus neurotoxic 3-OH-KYN and KYNA versus neurotoxic kynurenine: these ratios were lower in epilepsy patients than in controls, and they both moderately increased after VNS. "
12/01/1997 - "Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures."

11/21/2007 - "This study represents the first comprehensive characterization of the kynurenine pathway in neurons and the first description of the involvement of the kynurenine pathway as a mechanism for controlling both tumor cell neurotoxicity and persistence."
01/01/2015 - "An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells."
11/01/2013 - "Nevertheless, kynurenine levels pre- and post-treatment significantly predicted changes in depression, suggesting that heightened KP activation may contribute to depressive symptoms in patients treated for cancer. "
10/01/2013 - "These aggressive prostate tumors were further subdivided by abundance profiles of metabolites including NAD+ and kynurenine. "
12/15/2012 - "Tdo2 or Ido1 enzymatic activity has been implicated in a number of actions of the kynurenine pathway, including immune evasion by tumors. "

06/01/2015 - "Nonetheless, some evidence suggests an intriguing role for some kynurenines, and an exploratory study on the serum kynurenine level might be helpful to better understand possible alterations of the kynurenine pathway in patients suffering from migraine. "
06/01/2015 - "Despite the large number of studies conducted on migraine etio-pathology, the kynurenine pathway has been only recently linked to this disease. "
06/01/2011 - "Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives."
06/01/2015 - "Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important."
02/01/2012 - "This work summarizes our current results regarding the role of the kynurenine system in trigeminal activation and other events occurring during migraine headache."