A prion disease found exclusively among the Fore linguistic group natives of the highlands of NEW GUINEA. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773)
Also Known As:
Encephalopathy, Kuru; Kuru Encephalopathy
Networked: 133 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
2. Scrapie
3. Bovine Spongiform Encephalopathy (Mad Cow Disease)
4. Amyloid Plaque
5. Alzheimer Disease (Alzheimer's Disease)


1. Collinge, John: 10 articles (06/2015 - 06/2006)
2. Mead, Simon: 8 articles (06/2015 - 06/2006)
3. Whitfield, Jerome: 7 articles (06/2015 - 06/2006)
4. Alpers, Michael P: 7 articles (04/2012 - 06/2006)
5. Brandner, Sebastian: 4 articles (06/2015 - 03/2008)
6. Uphill, James: 4 articles (04/2012 - 11/2008)
7. Campbell, Tracy: 4 articles (04/2012 - 11/2008)
8. Poulter, Mark: 4 articles (04/2012 - 11/2008)
9. Hummerich, Holger: 4 articles (04/2012 - 11/2008)
10. Asante, Emmanuel A: 3 articles (06/2015 - 03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kuru:
1. Amyloid (Amyloid Fibrils)IBA
2. Acquired CJDIBA
3. AntibodiesIBA
4. Methionine (L-Methionine)FDA Link
5. Codon (Codons)IBA
6. Valine (L-Valine)FDA Link
7. ParaffinIBA
02/01/2009 - "Immunohistochemistry was performed on paraffin sections from one case of vCJD, two cases of GSS, one case of kuru and two cases of sCJD. "
03/01/2003 - "We examined paraffin-embedded brain sections of sporadic MV2 Creutzfeldt-Jakob disease (sCJD) with Kuru plaques, sporadic VV2 CJD with plaque-like PrP(sc) (the abnornal form of prion protein) deposits, variant CJD (vCJD) with florid plaques, Gerstmann-Straüssler-Scheinker (GSS) with multicentric plaques and of Alzheimer's disease (AD) with senile plaques. "
09/03/2003 - "The study aimed to evaluate the fluorescent molecular-imaging probe 2-(1-[6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile (FDDNP) for its ability to selectively and reproducibly label prion plaques in fixed, paraffin-embedded cerebellar sections from patients of confirmed Gerstmann-Sträussler-Scheinker disease, sporadic Creutzfeldt-Jacob disease (CJD) with kuru plaques, and variant CJD (vCJD). "
10/01/1988 - "We investigated paraffin-embedded brain sections from 41 patients with Creutzfeldt-Jakob disease (CJD) and from 9 with Gerstmann-Sträussler syndrome (GSS) using anti-human prion protein (PrP) antisera (anti-GSS kuru plaque cores and anti-PrP synthetic peptide) and anti-beta protein antiserum. "
12/01/1991 - "Formic acid pretreatment on formalin fixed, paraffin-embedded thin sections enhanced immunostaining of PrP in both congophilic and non-congophilic kuru plaques which were absent in sporadic CJD patients with short clinical courses. "
8. PeptidesIBA
9. Ferritins (Ferritin)IBA
10. dicyanmethane (malononitrile)IBA

Therapies and Procedures

1. Transplants (Transplant)
2. Dilatation and Curettage (D&C)