Kininogens (Kininogen)

Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.

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Networked: 364 relevant articles (2 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Colman, Robert W: 7 articles (02/2010 - 07/2002)
2.	Isordia-Salas, Irma: 6 articles (06/2007 - 07/2002)
3.	Kozik, Andrzej: 5 articles (01/2013 - 05/2005)
4.	Pixley, Robin A: 5 articles (07/2006 - 07/2002)
5.	Bhoola, Kanti D: 4 articles (12/2014 - 04/2004)
6.	Scharfstein, Julio: 4 articles (09/2009 - 01/2006)
7.	Sainz, Irma M: 4 articles (06/2007 - 01/2005)
8.	Figueroa, Carlos D: 3 articles (12/2014 - 07/2003)
9.	Wang, Mengjun: 3 articles (01/2013 - 06/2009)
10.	Di Bisceglie, Adrian M: 3 articles (01/2013 - 06/2009)

Related Diseases

1.	Myocardial Infarction 07/22/1978 - "Immunoreactive kininogen in acute myocardial infarction determined by single radial immunodiffusion using monospecific anti-kininogen serum." 04/01/1973 - "[Activity of the kininogen-kinin system in acute macrofocal myocardial infarct and its complications]." 01/01/1973 - "Plasma kininogen in patients with myocardial infarction." 07/17/1972 - "[Plasma kininogen in patients with myocardial infarct]." 01/01/1972 - "[Kininogen levels in patients with myocardial infarct]."
2.	Pancreatitis 05/01/2003 - "3 Total kininogen levels were very low in the pancreas of controls, but increased 75-fold during acute pancreatitis. " 01/01/1989 - "Both HMW and LMW kininogen decreased in acute pancreatitis. " 01/01/1986 - "In severe pancreatitis consumption of kininogen in the peritoneal cavity was demonstrated together with a final lowering of the plasma protease inhibitors. " 12/01/1978 - "The highest values for kallikrein, kininogen and kininase activity were found in patients in whom acute pancreatitis was accompanied by hemodynamic changes." 12/01/1978 - "Three chief components of the kallikrein-kinin system (kallikrein, kininogen, kininase) were studied in the blood of 42 patients with acute pancreatitis. "
3.	Hyperlipidemias (Hyperlipidemia) 01/01/1984 - "The degree of hyperlipidemia, hyperthyrosinemia, hyperserotoninemia and enhanced release of bradykinin from kininogen in patients with chronic recurrent pancreatitis was found to be decreased upon the attainment of a clinical remission. "
4.	Inflammation 01/01/1999 - "In this study, we evaluated the involvement of T-kininogen and macrophage migration inhibitory factor (MIF) in endotoxin-induced systemic inflammation. " 02/01/1976 - "Sequential studies showed that the fall in kininogen was very rapid, occurring within 1-2 hours of ingestion of drug, and was parallelled by reduction in the clinical indices of inflammation. " 05/01/2003 - "In addition, T-kininogen may be required to stimulate localized inflammation to aid tissue repair. " 12/01/2002 - "Chronic intestinal inflammation and angiogenesis in genetically susceptible rats is modulated by kininogen deficiency." 07/01/2002 - "Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats."
5.	Pain (Aches) 09/01/2003 - "Roles for the kallikrein-kinin system in inflammatory exudation and pain: lessons from studies on kininogen-deficient rats." 09/01/1992 - "Psychophysical studies were conducted in a patient with complete kininogen deficiency to determine whether the absence of bradykinin was associated with abnormalities in pain sensibility. " 03/01/2000 - "Our results suggest that pain on injection of propofol may be related to release of local kininogens and that nonsteroidal anti-inflammatory drugs may have a role in reducing that pain." 09/01/1992 - "Role of kinins in pain and hyperalgesia: psychophysical studies in a patient with kininogen deficiency." 01/01/1966 - "[Bradykinin (kininogen-kinin system) in the pathogenesis of myocardial pain and shock]."

Related Drugs and Biologics

1.	Bradykinin
2.	Tissue Kallikreins (Tissue Kallikrein)
3.	Kallikreins (Kallikrein)
4.	Kinins
5.	Carrageenan
6.	Plasma Kallikrein
7.	Factor XII (Hageman Factor)
8.	Prekallikrein
9.	Proteins (Proteins, Gene)
10.	alpha-Macroglobulins (alpha 2 Macroglobulin)

Related Therapies and Procedures

1.	Cholecystectomy
2.	Nephrectomy
3.	Intravenous Injections
4.	Thrombolytic Therapy
5.	Tourniquets