Medullary Sponge Kidney

A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
Also Known As:
Cacchi Ricci Disease; Cacchi-Ricci Syndrome; Kidney, Sponge; Precalyceal Canalicular Ectasia; Cacchi Ricci Syndrome; Canalicular Ectasia, Precalyceal; Canalicular Ectasias, Precalyceal; Disease, Cacchi Ricci; Ectasia, Precalyceal Canalicular; Ectasias, Precalyceal Canalicular; Kidneys, Sponge; Medullary Sponge Kidneys; Precalyceal Canalicular Ectasias; Ricci Disease, Cacchi; Sponge Kidney; Sponge Kidney, Medullary; Sponge Kidneys; Sponge Kidneys, Medullary; Syndrome, Cacchi-Ricci
Networked: 60 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Hydronephrosis
3. Pathologic Dilatation (Ectasia)
4. Bacteriuria
5. Renal Tubular Acidosis (Distal Renal Tubular Acidosis)


1. Gambaro, Giovanni: 5 articles (04/2015 - 12/2009)
2. Fabris, Antonia: 5 articles (04/2015 - 12/2009)
3. Lupo, Antonio: 4 articles (02/2013 - 12/2009)
4. Anglani, Franca: 3 articles (04/2015 - 07/2010)
5. Abaterusso, Cataldo: 3 articles (09/2010 - 12/2009)
6. Marchionna, Nicola: 3 articles (09/2010 - 12/2009)
7. Evan, Andrew P: 2 articles (11/2015 - 12/2010)
8. Lingeman, James E: 2 articles (11/2015 - 12/2010)
9. Coe, Fredric L: 2 articles (11/2015 - 12/2010)
10. Daudon, Michel: 2 articles (05/2015 - 12/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Medullary Sponge Kidney:
1. ThiazidesIBA
2. CalciumIBA
3. Calcium OxalateIBA
4. calcium phosphateIBA
5. Citric Acid (Citrate)FDA LinkGeneric
6. familial juvenile NephronophthisisIBA
08/01/1995 - "Among them, juvenile nephronophthisis and medullary sponge kidney, which primarily involve the tubule structures of the renal medulla, are associated with variable enlargement of the distal tubules and collecting ducts and with interstitial fibrosis and inflammation of a variable extent. "
01/01/1976 - "Its major categories are as follows: (1) dysplastic cysts arising in kidneys that have undergone abnormal morphogenesis and differentiation; (2) polycystic disease of autosomal recessive and autosomal dominant types; (3) heritable syndromes of multiple malformations with renal cysts resulting from presumed metabolic injury; (4) isolated cortical cysts of unknown pathogenesis; (5) medullary cysts of several types, including medullary sponge kidney and the progressive syndromes of medullary cystic disease, familial juvenile nephronophthisis, and renal-retinal dysplasia; (6) acquired parenchymal cysts of diverse origins; and (7) extraparenchymal cysts. "
01/01/2006 - "The conditions included are autosomal-dominant polycystic kidney disease, autosomal-recessive polycystic kidney disease, unilateral renal cystic disease (localized cystic disease), renal simple cysts, multicystic dysplastic kidney, pluricystic kidney of the multiple malformation syndromes, juvenile nephronophthisis and medullary cystic disease, medullary sponge kidney, primary glomerulocystic kidney disease, and glomerulocystic kidney associated with several systemic disorders mainly of genetic or chromosomal etiology, cystic kidney in tuberous sclerosis, and in von Hippel-Lindau syndrome, cystic nephroma, cystic variant of congenital mesoblastic nephroma, mixed epithelial stromal tumor of the kidney, renal lymphangioma, pyelocalyceal cyst, peripylic cyst and perinephric pseudocyst, acquired renal cystic disease of long-term dialysis, and cystic renal cell carcinoma and sarcoma. "
7. tranilast (N 5')IBA
8. Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
9. Potassium CitrateFDA LinkGeneric
10. Uric Acid (Urate)IBA

Therapies and Procedures

1. Nephrectomy
2. Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3. Intravenous Infusions
4. Catheters
5. Solid-State Lasers