HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Medullary Sponge Kidney

A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
Also Known As:
Cacchi Ricci Disease; Cacchi-Ricci Syndrome; Kidney, Sponge; Precalyceal Canalicular Ectasia; Cacchi Ricci Syndrome; Canalicular Ectasia, Precalyceal; Canalicular Ectasias, Precalyceal; Disease, Cacchi Ricci; Ectasia, Precalyceal Canalicular; Ectasias, Precalyceal Canalicular; Kidneys, Sponge; Medullary Sponge Kidneys; Precalyceal Canalicular Ectasias; Ricci Disease, Cacchi; Sponge Kidney; Sponge Kidney, Medullary; Sponge Kidneys; Sponge Kidneys, Medullary; Syndrome, Cacchi-Ricci
Networked: 81 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Kidney Calculi (Kidney Stone)
2. Infections
3. Pathologic Dilatation (Ectasia)
4. Hydronephrosis
5. Bacteriuria

Experts

1. Gambaro, Giovanni: 11 articles (01/2021 - 12/2009)
2. Fabris, Antonia: 9 articles (11/2019 - 12/2009)
3. Lupo, Antonio: 7 articles (01/2019 - 12/2009)
4. Zaza, Gianluigi: 6 articles (06/2022 - 01/2017)
5. Bruschi, Maurizio: 5 articles (06/2022 - 01/2017)
6. Candiano, Giovanni: 5 articles (06/2022 - 01/2017)
7. Granata, Simona: 5 articles (06/2022 - 01/2017)
8. Petretto, Andrea: 5 articles (06/2022 - 01/2017)
9. Ghiggeri, Gian Marco: 4 articles (06/2022 - 01/2017)
10. Anglani, Franca: 3 articles (04/2015 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Medullary Sponge Kidney:
1. Anti-Bacterial Agents (Antibiotics)IBA
2. ThiazidesIBA
3. Potassium CitrateFDA LinkGeneric
4. CalciumIBA
5. Calcium OxalateIBA
12/01/2010 - "This report shows exemplary cases of primary hyperparathyroidism, type I distal renal tubular acidosis, medullary sponge kidney, and common calcium oxalate stone formation. "
11/01/2011 - "The etiology of metabolic stone disease was calcium oxalate (40%), cystinuria (33%), type 1 renal tubular acidosis (14%), calcium oxalate/urate (7%) and medullary sponge kidney (7%). "
11/01/2015 - "We studied patients undergoing percutaneous nephrolithotomy who had calcium phosphate or calcium oxalate stones and did not have hyperparathyroidism, distal renal tubular acidosis or medullary sponge kidney disease. "
12/01/2016 - "The groups studied and reviewed here are kidney stone formers who have a history of idiopathic calcium oxalate stone formation, cystinuria, brushite stones, gastric bypass, ileostomy, small bowel resection, primary hyperparathyroidism, distal renal tubular acidosis (dRTA), primary hyperoxaluria, idiopathic calcium phosphate stone formation, medullary sponge kidney (MSK), uric acid stones, and struvite stones. "
07/01/1996 - "Subtle underlying defects are detected not infrequently in these patients; for example, medullary sponge kidneys, abnormally structured macromolecular inhibitors of calcium oxalate crystallization (nephrocalcin and Tamm-Horsfall protein), incomplete distal renal tubular acidosis, deficient activation of pyridoxine, defective intestinal absorption of citrate, excessive production of interleukin-1 by monocytes, subtle primary hyperparathyroidism, heterozygosity for cystinuria, and, discovered more recently, abnormal chloride channels along the nephron. "
6. calcium phosphateIBA
7. Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
8. AcidsIBA
9. Citric Acid (Citrate)FDA LinkGeneric
10. Uric Acid (Urate)IBA

Therapies and Procedures

1. Nephrectomy
2. Percutaneous Nephrolithotomy
3. Therapeutics
4. Lithotripsy (Extracorporeal Shockwave Lithotripsy)
5. Intravenous Infusions