Kidney Diseases (Kidney Disease)

03/01/2013 - "Laboratories in African should commence routine reporting of eGFR for a number of reasons; 1. The sensitivity of serum creatinine (Scr) in identifying CKD is low.2. In Nigeria, a representative country; screening for Chronic Kidney Disease (CKD) is hardly considered in the routine practice of the primary and secondary care medical officers.3 Studies have shown that routine reporting of eGFR improved the documentation and identification of CKD by almost 50%.4 There is the possibility of reversing CKD if picked earlier.5. The high cost of treating CKD patients in advanced stages and the low per capital income status of the populace in Sub-Saharan Africa.6. Poor health infrastructure to manage advanced CKD patients in the continent.7. Several studies, now show lack of awareness of CKD among non-nephrologists that is related, at least in part, to difficulty in interpreting serum creatinine concentrations (the reciprocal, non-linear relationship between GFR and serum creatinine).8 Mathematical estimates of GFR [ as in eGFR] that incorporate creatinine concentration, as well as factors affecting creatinine production rates, such as size, gender, age and ethnic background, are more sensitive to changes in renal function than serum creatinine value alone.9 Recent guidelines define "action plans" for CKD according to the GFR, including referral to nephrologists at GFRs<30 mL.min(-1).(1.73 m2)."
01/01/2004 - "Regardless of the choice between an ACE or ARB, however, post hoc analysis of clinical trials [21,47] and observational data clearly indicate that patients with chronic kidney disease, even if considered mild (ie, serum creatinine greater than or equal to 1.4 mg/dL) are at significantly greater risk of cardiovascular morbidity and mortality compared with those with better kidney function. "
01/01/2015 - "Modified Cut-Off Value of the Urine Protein-To-Creatinine Ratio Is Helpful for Identifying Patients at High Risk for Chronic Kidney Disease: Validation of the Revised Japanese Guideline."
03/01/2013 - "Patients with false, relative to those with true, isolated-office RH had higher prevalence of microalbuminuria and chronic kidney disease (CKD), significantly higher albumin/creatinine ratio (p < .001), significantly higher 48-h SBP/DBP means by 9.6/5.3 mm Hg (p < .001), significantly lower sleep-time relative SBP and DBP decline (p < .001), and significantly greater prevalence of a non-dipper BP profile (96.9% vs. 38.9%; p < .001). "
01/01/2014 - "The CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) creatinine equation performed better than the MDRD (Modification of Diet in Renal Disease) Study equation in terms of greater accuracy at P30 (76.1% [95% CI, 72.7%-79.5%] vs 68.0% [95% CI, 64.3%-71.7%]; P < 0.001) and improved precision (IQR, 22.6 [95% CI, 19.9-25.3] vs 28.6 [95% CI, 25.8-31.5] mL/min/1.73 m(2); P < 0.001). "

04/01/2007 - "Iron deficiency can easily be corrected by intravenous iron administration, which is more effective than oral iron supplementation, at least in adult patients with chronic kidney disease (CKD). "
06/01/2013 - "Iron deficiency often occurs in patients with chronic kidney disease and can be effectively treated with parenteral supplementation of iron. "
10/01/2005 - "Administration of safe and effective iron therapy in patients with chronic kidney disease is a time consuming process. "
07/01/2015 - "Intravenous iron treatment was associated with improved myocardial functional parameters and cardiac dimensions in patients with anaemia and chronic kidney disease."
01/01/2014 - "To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not pregnant or lactating and do not have chronic kidney disease. "

08/01/1999 - "Risk factors of hypovitaminosis such as an inadequately varied diet; low exposure to sunlight, chronic liver and kidney disease and treatment affecting the metabolism and clearance of vitamin D are very frequent in elderly patients hospitalized in medical departments. "
03/01/2007 - "This article reviews the basic physiology of vitamin D, the survival data in patients receiving vitamin D, and the current quandary of whether vitamin D administration is beneficial in chronic kidney disease. "
06/01/2010 - "Thus, our study further shows that vitamin D analogs can increase the efficacy of AT1 receptor blockade, leading to a more effective prevention of kidney disease in type 2 diabetes."
09/01/2013 - "This review critically assesses ongoing controversies surrounding the relationship between vitamin D and racial disparities in chronic kidney disease outcomes, and how FGF23 may help to clarify the picture. "
04/01/2013 - "Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bone disorders (CKD-MBD) in children."

01/01/2011 - "Renovascular protective effects of erythropoietin in patients with chronic kidney disease."
08/01/2007 - "Early erythropoietin therapy is associated with improved growth in children with chronic kidney disease."
01/01/2012 - "Several studies have shown an association between erythropoietin-stimulating agent (ESA) responsiveness and mortality in chronic kidney disease (CKD) patients. "
07/01/2011 - "In this trial, normalization of Hb level in T2DM patients with chronic kidney disease was safe but did not significantly slow renal function decline and increased treatment cost due to erythropoietin use."
08/01/2007 - "Recent studies have shown a renoprotective effect of erythropoietin (EPO) during ischemic kidney disease. "

12/01/2014 - "The introduction of erythropoiesis-stimulating agents (ESAs) markedly improved the lives of many anaemic patients with chronic kidney disease (CKD). "
12/01/2015 - "Erythropoiesis-stimulating agents (ESAs) are all effective for renal anaemia in patients with chronic kidney disease (CKD). "
05/01/2013 - "Erythropoiesis-stimulating agents (ESAs) are the mainstay of treatment in anemic chronic kidney disease (CKD) patients. "
01/01/2007 - "Erythropoiesis-stimulating agents (ESAs) are effective in the management of the anaemia of chronic kidney disease but add substantially to the treatment costs. "
09/01/2008 - "Erythropoiesis-stimulating agents (ESAs) have transformed the management of anaemia in patients with chronic kidney disease (CKD), reducing transfusion requirements and leading to improved quality of life. "

06/01/2007 - "Monotherapy with angiotensin-converting enzyme inhibitors has been shown to be beneficial in suppressing the progression of experimentally induced kidney diseases. "
08/19/2003 - "11 randomized, controlled trials comparing the efficacy of antihypertensive regimens with or without ACE inhibitors for patients with predominantly nondiabetic kidney disease. "
01/01/2010 - "ACE inhibitors can also be helpful in slowing the progression of kidney disease, especially in diabetics. "
11/01/2002 - "ACE inhibitors and protection against kidney disease progression in patients with type 2 diabetes: what's the evidence."
04/01/2010 - "Key clinical trials supporting the use of ACE inhibitors and ARBs in chronic kidney disease are discussed. "

01/01/2013 - "Cinacalcet in patients with chronic kidney disease: a cumulative meta-analysis of randomized controlled trials."
07/01/2015 - "[The use of Cinacalcet in chronic kidney disease: a case report]."
01/01/2015 - "Cinacalcet, a calcimimetic drug, has been shown to be efficacious in adult chronic kidney disease (CKD) patients; however, it was not fully studied in pediatric CKD patients. "
01/01/2015 - "Cinacalcet in pediatric and adolescent chronic kidney disease: a single-center experience."
04/01/2013 - "In addition, the subjects in the d-cinacalcet group had a greater proportion to achieve Kidney Disease Outcomes Quality Initiative (KDOQI)-recommended biochemical targets than the subjects in the VitD group (Ca: 48% vs. 24%; P: 78% vs. 32%; Ca × P: 85% vs. 37%; iPTH: 15% vs. 0%). "

10/01/2011 - "Positive outcomes of high hemoglobin target in patients with chronic kidney disease not on dialysis: a randomized controlled study."
02/01/2010 - "Maintaining high hemoglobin levels improved the left ventricular mass index and quality of life scores in pre-dialysis Japanese chronic kidney disease patients."
01/01/2015 - "administered once monthly corrects and maintains stable hemoglobin levels in chronic kidney disease patients not on dialysis: the observational study MICENAS II."
07/01/2013 - "The aim of this study was to determine what effect these pivotal studies had on hemoglobin levels and survival Data were extracted from Australia's Renal Anaemia Database for patients with chronic kidney disease between October 2000 and December 2009. "
07/01/2013 - "The CHOIR and CREATE studies led to changes in hemoglobin targets around the world for patients with chronic kidney disease. "

09/01/2010 - "The use of reliable biomarkers is becoming increasingly important for the improved management of patients with acute and chronic kidney diseases. "
12/01/2009 - "Beyond phosphate binding: the effect of binder therapy on novel biomarkers may have clinical implications for the management of chronic kidney disease patients."
11/01/2009 - "These biomarkers can influence the assessment of efficacy of new drugs for kidney diseases as well as the risk management for new drugs. "
01/01/2013 - "Therefore, it is critical that functional tests be developed and used in combination with biomarkers, thus allowing improved care in AKI and chronic kidney disease patient populations. "
11/01/2015 - "Surrogate endpoints in clinical trials of chronic kidney disease progression: moving from single to multiple risk marker response scores."

03/01/2015 - "J Am Soc Nephrol 2009;20:629-37; Schwartz et al. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. "
08/01/2012 - "Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C."
10/01/2014 - "The final study population included 37 patients with SCI. The Chronic Kidney Disease Epidemiology Collaboration cystatin C equation provided significantly less bias, greater precision, and superior accuracy when used in the PK model. "
03/01/2014 - "Chronic kidney disease defined by cystatin C predicts mobility disability and changes in gait speed: the Framingham Offspring Study."
01/01/2014 - "In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease. "

11/01/2015 - "Living donor kidney transplantation (LDKT) is the best treatment option in the late stage of chronic kidney disease. "
09/04/2015 - "Live-donor kidney transplantation (LDKT) is the best treatment for eligible people with late-stage kidney disease. "
04/01/2015 - "Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. "
05/01/2014 - "Kidney transplantation is the best treatment option in chronic kidney disease patients. "
01/01/2014 - "Renal transplantation is surely the best treatment for Chronic Kidney Disease (CKD) patients in both developed and developing countries. "

01/01/2010 - "Renal transplant is the best option of treatment of chronic kidney disease and the shortage of cadaveric donors has caused the rapid increase of living donor programs. "
01/01/2014 - "Renin-angiotensin system (RAS) inhibition has proven to be helpful in reducing cardiovascular and kidney disease progression in the general population; whether kidney transplant patients would derive similar benefits is unknown. "
01/01/2015 - "In chronic kidney disease patients with this entity, there have been good outcomes associated with renal transplant and subsequent immunosuppression. "
08/01/2009 - "The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on the management of chronic kidney disease-mineral and bone disorder (CKD-MBD) is intended to assist the practitioner caring for adults and children with CKD stages 3-5, on chronic dialysis therapy, or with a kidney transplant. "
01/01/2012 - "Similarities between chronic graft injury and chronic kidney disease (CKD) suggest that the same therapeutic antiproteinuric tools should be effective in kidney-transplanted patients. "

01/01/2011 - "Many observational studies have consistently shown that high-flux hemodialysis (hf-HD) has positive effects on the survival and morbidity of chronic kidney disease stage 5 dialysis (CKD5D) patients when compared with low-flux hemodialysis, but the primary analysis of the prospective randomized Hemodialysis Outcomes (HEMO) study showed that the use of hf-HD was not associated with a significant reduction of the relative risk of mortality. "
07/01/2012 - "Moreover, the serum-free concentration of PCS, which is associated with its efficacy of hemodialysis, appears to be a good predictor of survival in chronic kidney disease (CKD). "
01/01/2012 - "Our results suggest that frequent nocturnal hemodialysis is not associated with an improvement in sexual activity in all patients but might have an effect on the burden of kidney disease on sex life in women and patients less than 60 years of age. "
04/01/2009 - "In-center nocturnal hemodialysis: another option in the management of chronic kidney disease."
07/01/2007 - "The emergence of these hemodialysis regimens has shown promise in attenuating some of the complications associated with chronic kidney disease. "

01/01/2015 - "When T1DM patients develops advanced chronic kidney disease, simultaneous pancreas-kidney (SPK) transplantation becomes the best option. "
01/01/2014 - "Improved renal function in liver transplant recipients treated for hepatitis C virus with a sustained virological response and mild chronic kidney disease."
11/01/2015 - "Medical management of chronic kidney disease in the renal transplant recipient."
07/01/2010 - "A discrete choice experiment was utilized to understand and quantify the preferences of 351 Canadian patients and healthcare providers in relation to ethically challenging aspects of the management of chronic kidney disease (CKD): procurement and allocation of organs for transplantation, end-of-life care discussions and decision making and the identities of those providing primary care. "
03/01/2015 - "The expectations and attitudes of patients with chronic kidney disease toward living kidney donor transplantation: a thematic synthesis of qualitative studies."

09/01/2006 - "Radical nephrectomy is a significant risk factor for the development of chronic kidney disease and might no longer be regarded as the gold standard treatment for small, renal cortical tumours."
12/01/2015 - "Recent studies demonstrate that PN confers better survival, oncologic equivalence and lower risk of severe chronic kidney disease compared to radical nephrectomy becoming then the gold-standard surgical technique, even if increasingly challenged by laparoscopic and/or robot-assisted partial nephrectomy which in the hands of experts seems to achieve comparable outcome results albeit with slightly higher complication rate. "
04/01/2010 - "Partial nephrectomy (PN) provides similar oncological control as radical nephrectomy (RN) and is superior to RN with respect to preserving renal function and preventing chronic kidney disease. "
03/01/2010 - "Accurate renal function determination before and after nephrectomy is essential for proper prevention and management of chronic kidney disease due to nephron loss and ischemic injury. "
07/01/2015 - "The study presents a matched-pair analysis of robot-assisted laparoscopic partial nephrectomy (RALPN) versus radiofrequency ablation (RFA) to compare the perioperative incidence of complications and chronic kidney disease (CKD). "