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Ketotifen (Ketotifene)

A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.

Also Known As:

Ketotifene; Zaditen; 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one; Ketotifen Fumarate; Ketotiphen; Ketotiphene; Fumarate, Ketotifen; 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-

Networked: 589 relevant articles (102 outcomes, 115 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hung, Chih-Hsing: 5 articles (01/2013 - 06/2005)
2.	Jong, Yuh-Jyh: 4 articles (01/2013 - 01/2007)
3.	Hua, Yi-Ming: 4 articles (12/2007 - 06/2005)
4.	Abelson, Mark B: 4 articles (12/2004 - 07/2002)
5.	Shams, Naveed B K: 4 articles (12/2003 - 07/2002)
6.	Hildebrand, Kevin A: 3 articles (04/2012 - 03/2008)
7.	Hart, David A: 3 articles (04/2012 - 03/2008)
8.	Boeckxstaens, Guy E: 3 articles (09/2010 - 08/2004)
9.	Yang, Kuender D: 3 articles (12/2007 - 06/2005)
10.	Hung, Chen-Road: 3 articles (01/2005 - 01/2004)

Related Diseases

1.	Asthma (Bronchial Asthma) 08/01/1997 - "Compared with the placebo, the ketotifen-treated group exhibited significant improvement of asthma symptoms (P < 0.05) and bronchial responsiveness (P < 0.05). " 03/01/1982 - "Children receiving ketotifen were more likely to reduce concomitant medications and had significant improvement over time in asthma scores and mean flows at 75%, 50%, and 25% of vital capacity. " 01/01/1995 - "In conclusion, Zaditen SRO (4 mg once daily) was found to be equally safe and more effective in the prophylactic treatment of mild and moderate bronchial asthma than Zaditen Standard Form (1 mg twice daily)." 01/01/1995 - "Zaditen SRO permits once-daily dosing with superior efficacy in the prophylaxis of asthma." 03/01/2001 - "Ketotifen fumarate is effective in low doses in the treatment of bronchial asthma particularly of allergic origin. "
2.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 12/01/2004 - "These results indicate that ketotifen fumarate 0.025% ophthalmic solution is an effective and safe treatment option for children with allergic conjunctivitis." 05/01/2003 - "To assess the efficacy of ketotifen 0.025% ophthalmic solution in the prevention of symptoms of allergic conjunctivitis, using the conjunctival allergen challenge model. " 08/01/2003 - "To study the effectiveness of ketotifen ophthalmic solution (0.25 mg/ml) in seasonal allergic conjunctivitis (SAC) and the impact on the patient's quality of life. " 01/06/2003 - "The effect of ketotifen on inflammatory markers in allergic conjunctivitis: an open, uncontrolled study." 07/01/2009 - "[Comparison of olopatadin and ketotifen in the treatment of allergic conjunctivitis]."
3.	Pruritus (Itching) 09/01/2013 - "This study showed that oral ketotifen and topical antibiotic therapy can be helpful in the management of pruritus in PN patients." 12/01/2003 - "For both studies, ocular itching and vascular injection were significantly reduced (P <.003) at all time points after instillation of ketotifen, with a maximum reduction at 7 minutes postchallenge. " 05/01/2003 - "At visits 3, 4, and 5, mean itching scores were significantly better for ketotifen-treated eyes at all postchallenge time points, compared with placebo (P<.001). " 03/01/2003 - "Ketotifen significantly lowered itching at 5 and 10 minutes (p < 0.001) and redness at 5, 10, and 15 minutes (p < 0.05). " 12/01/1991 - "We further examined the effects of ketotifen, a putative mast cell stabilizer, on severe uremic pruritus. "
4.	Rhinitis 07/01/1981 - "The atopic patients who had symptoms of rhinitis showed significant improvement on ketotifen over the treatment period. " 01/01/1989 - "Double-blind experiment (at random) comparative of the efficacy of ketotifen and Clemastina, for the treatment of periodic allergic Rhinitis. " 05/01/2015 - "This study was designed to compare the effects of ketotifen drops and oral ketotifen pills on symptoms and quality of life in allergic rhinitis patients. " 01/01/1991 - "The histological and histochemical effects of ketotifen in allergic rhinitis." 04/01/1990 - "We report the data of an allergic rhinitis population to evaluate the eventual modifications in sleep pattern brought upon by ketotifen."
5.	Anaphylaxis (Anaphylactic Shock) 08/01/1997 - "Ketotifen is shown to be successful in inducing remission in two patients with malignant idiopathic anaphylaxis and in three additional patients with corticosteroid-dependent idiopathic anaphylaxis. " 08/01/1997 - "Ketotifen has been reported to help induce remission in some patients with idiopathic anaphylaxis and has steroid sparing effects in other patients with idiopathic anaphylaxis. " 09/01/1991 - "Efficacy of ketotifen in corticosteroid-dependent idiopathic anaphylaxis." 05/01/2009 - "We herein report an interesting case of wheat-dependent, exercise-induced anaphylaxis with successful prevention by ketotifen." 05/01/2009 - "Wheat-dependent, Exercise-induced Anaphylaxis: A Successful Case of Prevention with Ketotifen."

Related Drugs and Biologics

1.	Cromolyn Sodium (Cromoglicic Acid)
2.	Ketotifen (Ketotifene)
3.	olopatadine (Patanol)
4.	Ophthalmic Solutions (Eye Drops)
5.	Histamine (Histamine Dihydrochloride)
6.	epinastine
7.	Chlorpheniramine (Chlorphenamine)
8.	Immunoglobulin E (IgE)
9.	Antigens
10.	montelukast (Singulair)

Related Therapies and Procedures

1.	Topical Administration
2.	Oral Administration
3.	Immunotherapy
4.	Aftercare (After-Treatment)
5.	Chemoprevention