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Ketoprofen (Orudis)

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.

Also Known As:

Orudis; 19,583 RP; 2-(3-Benzoylphenyl)propionic Acid; Alrheumat; Alrheumum; Profenid; RP-19583; RP 19583; RP, 19,583; RP19583; Benzoylhydratropic Acid; Benzeneacetic acid, 3-benzoyl-alpha-methyl-

Networked: 806 relevant articles (122 outcomes, 207 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Carboxylic Acids: 83
  - Carbocyclic Acids
    - Phenylpropionates
      - Ketoprofen: 806
        dexketoprofen trometamol: 52
        ketoprofen lysine: 21
        piketoprofen: 4
        ketoprofen topical gel: 3
        ketoprofen glucuronide: 1
        2-amino-3-(4-(2-(3-benzoylphenyl)propionyloxy)phenyl)propionic acid
        OMS 103HP

Experts

1.	Kokki, Hannu: 12 articles (10/2010 - 01/2002)
2.	Rother, Matthias: 8 articles (01/2016 - 09/2007)
3.	Kokki, H: 7 articles (08/2015 - 01/2000)
4.	Tokura, Yoshiki: 5 articles (08/2012 - 02/2006)
5.	Seidel, Egbert J: 4 articles (01/2016 - 09/2007)
6.	Duffield, Todd F: 4 articles (05/2014 - 03/2010)
7.	Kneer, Werner: 4 articles (04/2014 - 09/2007)
8.	Atarashi, Kenji: 4 articles (08/2012 - 02/2006)
9.	Yamauchi, Hitoshi: 4 articles (03/2010 - 02/2005)
10.	Popov, I: 4 articles (01/2009 - 01/2005)

Related Diseases

1.	Pain (Aches) 11/01/2011 - "Combination of ketoprofen and trimeperiden showed best results in pain management. " 10/06/1984 - "The double-blind method made it possible to confirm that ketoprofen administered alone relieved pain in 97% of the patients (with complete sedation in 45%) and acted within 5 minutes. " 08/01/2015 - "Ketoprofen has high analgesic efficacy against inflammatory and nociceptive pain. " 07/01/2001 - "The maximum pain suppression with 100 mg topical 2.5% ketoprofen gel was by 51% (significant with P<0.03), while 50 mg topical ketoprofen produced a non-significant reduction of 29%. " 11/01/1993 - "Pain at rest was significantly relieved in the ketoprofen group, whereas in the placebo group the difference was not significant. "
2.	Postoperative Pain 11/01/1993 - "Ketoprofen at both dose levels was shown to be effective, long-lasting, and well tolerated, and it should be considered as a viable option for the management of moderate to severe postoperative pain." 07/01/1996 - "A bolus of ketoprofen following continuous infusion of ketoprofen, coupled with a PCA-system, was an effective and safe approach for the relief of postoperative pain." 08/01/1991 - "The results of this study confirm the efficacy of ketoprofen for the prophylaxis of postoperative pain in abdominal surgery." 02/01/2000 - "The efficacy of buffered ketoprofen in postoperative pain after third molar surgery." 05/01/1999 - "We conclude that ketoprofen improved postoperative pain in children. "
3.	Rheumatoid Arthritis 10/01/2010 - "Efficacy and safety of ketoprofen patch in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study." 07/01/1986 - "Acute and chronic pharmacokinetic studies of slow release ketoprofen (Oruvail) in rheumatoid arthritis." 01/01/1979 - "Clinical studies with ketoprofen in rheumatoid arthritis." 01/01/1976 - "A study was made of the plasma and synovial-fluid levels of ketoprofen after single oral doses of 50 mg and 100 mg given to patients with rheumatoid arthritis. " 01/01/1976 - "The study indicates that ketoprofen may prove to be a valuable drug in the treatment of rheumatoid arthritis."
4.	Osteoarthritis 01/01/2013 - "To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. " 01/01/2013 - "A 12-week randomized study of topical therapy with three dosages of ketoprofen in Transfersome® gel (IDEA-033) compared with the ketoprofen-free vehicle (TDT 064), in patients with osteoarthritis of the knee." 06/01/1993 - "Ketoprofen controlled release (CR) in the treatment of osteoarthrosis; a double blind, randomized multicentre study of single morning versus evening dose. " 04/01/1988 - "A prospective endoscopic study of the effect of Orudis and Oruvail on the upper gastrointestinal tract, in patients with osteoarthritis." 07/01/1984 - "Eighty patients with osteoarthritis of various localization completed a double-blind, parallel-group trial of 2 weeks' duration comparing the efficacy and tolerance of ketoprofen slow-release capsules (150 mg) given either as a morning or a midday or an evening dose with that of ketoprofen conventional capsules (50 mg) 3X daily. "
5.	Migraine Disorders (Migraine) 06/11/2002 - "Efficacy of oral ketoprofen in acute migraine: a double-blind randomized clinical trial." 06/11/2002 - "The authors report a double-blind, placebo-controlled, randomized cross-over trial of a dual-release formulation of oral ketoprofen in the acute treatment of migraine attacks. " 06/11/2002 - "Oral ketoprofen (75 mg or 150 mg) in a dual-release formulation is an effective and well-tolerated drug in the acute treatment of migraine attacks." 01/01/1997 - "Our findings suggest that ketoprofen produced statistically significant benefit in the treatment of acute migraine." 07/01/2002 - "This study was designed to evaluate the efficacy of topical ketoprofen for the prevention of migraine, tension-type, and posttraumatic headache. "

Related Drugs and Biologics

1.	Ibuprofen (Motrin)
2.	Diclofenac (SR 38)
3.	Acetaminophen (Paracetamol)
4.	Naproxen (Naprosyn)
5.	Indomethacin (Indometacin)
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
7.	Ketoprofen (Orudis)
8.	Morphine (MS Contin)
9.	Aspirin (Acetylsalicylic Acid)
10.	Ketorolac

Related Therapies and Procedures

1.	Analgesia
2.	Tonsillectomy
3.	Cesarean Section (Caesarean Section)
4.	Adenoidectomy
5.	Injections