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Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)

Subscribe to New Research on Ketoglutarate Dehydrogenase Complex

Also Known As:

Oxoglutarate Dehydrogenase; alpha-Ketoglutarate Dehydrogenase; alpha-Ketoglutarate Dehydrogenase Complex; 2-Keto-4-Hydroxyglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase; 2-Oxoglutarate Dehydrogenase Complex; 2 Keto 4 Hydroxyglutarate Dehydrogenase; 2 Oxoglutarate Dehydrogenase; 2 Oxoglutarate Dehydrogenase Complex; Complex, 2-Oxoglutarate Dehydrogenase; Complex, Ketoglutarate Dehydrogenase; Complex, alpha-Ketoglutarate Dehydrogenase; Dehydrogenase Complex, 2-Oxoglutarate; Dehydrogenase Complex, Ketoglutarate; Dehydrogenase Complex, alpha-Ketoglutarate; Dehydrogenase, 2-Keto-4-Hydroxyglutarate; Dehydrogenase, 2-Oxoglutarate; Dehydrogenase, Oxoglutarate; Dehydrogenase, alpha-Ketoglutarate; alpha Ketoglutarate Dehydrogenase; alpha Ketoglutarate Dehydrogenase Complex; 2-Oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating)

Networked: 142 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Gibson, Gary E: 12 articles (12/2011 - 03/2002)
2.	Xu, Hui: 7 articles (11/2009 - 03/2002)
3.	Gibson, G E: 6 articles (03/2011 - 01/2000)
4.	Shi, Qingli: 5 articles (12/2011 - 03/2005)
5.	Blass, J P: 4 articles (03/2011 - 02/2000)
6.	Butterworth, Roger F: 4 articles (03/2009 - 05/2002)
7.	Starkov, Anatoly A: 3 articles (07/2013 - 03/2004)
8.	Beal, M Flint: 3 articles (01/2010 - 03/2004)
9.	Blass, John P: 3 articles (01/2010 - 01/2004)
10.	Calingasan, N Y: 3 articles (06/2008 - 01/2000)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 12/01/2011 - "The activity of the α-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme complex that mediates the oxidative decarboxylation of α-ketoglutarate in the TCA cycle, is reduced in Alzheimer's disease. " 01/01/2010 - "Many experiments in tissues from humans support the notion that oxidative modification of the alpha-ketoglutarate dehydrogenase complex (KGDHC) compromises neuronal energy metabolism and enhances ROS production in Alzheimer's Disease (AD). " 11/15/2004 - "Abundant biochemical evidence links deficient activity of mitochondrial alpha-ketoglutarate dehydrogenase with neuropathologically confirmed Alzheimer's disease (AD). " 09/01/2000 - "Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme, are diminished in brains from patients with Alzheimer's disease (AD). " 01/01/1999 - "The mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is deficient in Alzheimer's disease (AD). "
2.	Parkinson Disease (Parkinson's Disease) 02/01/1994 - "We report an immunohistochemical study of the mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) in the substantia nigra in Parkinson's disease. " 02/01/1994 - "An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease." 01/01/1998 - "Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease." 05/30/1995 - "Defects in complex I and alpha-ketoglutarate dehydrogenase (alpha-KGDH) occur in the substantia nigra in Parkinson's disease (PD). " 02/01/2002 - "An association between both Alzheimer disease and Parkinson s disease and the 2-oxoglutarate dehydrogenase gene has been reported. "
3.	Hypokinesia (Bradykinesia) 01/01/1990 - "The activity of alpha-ketoglutarate dehydrogenase and succinic dehydrogenase in readaptation after 15-day hypokinesia was within normal limits, whereas following 30-day hypokinesia it was enhanced on days 11-15. " 09/01/1989 - "Activity of alpha-ketoglutarate dehydrogenase (KGDH) and succinate dehydrogenase (SDH) decreased immediately after hypokinesia and remained lowered till day 18. " 01/01/1983 - "On hypokinesia days 30 and 45 the activity of succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) decreased, that of cytoplasmatic malate dehydrogenases (MDH) slightly increased, and that of NADP ICDH declined. " 11/01/1982 - "The study of 165 rats exposed to 60-day hypokinesia demonstrated a decrease in the quantity of mitochondrial protein and a decline in the activity of mitochondrial forms of NADP-isocitrate dehydrogenase (NADP-ICDH) and NAD-malate dehydrogenase (NAD-MDH), as well as NAD-ICDH, succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH). "
4.	Anoxia (Hypoxia) 10/01/2010 - "Interestingly, in MCF-7 cells, 24h hypoxia decreased OxPhos flux (4-6-fold), and 2-oxoglutarate dehydrogenase and glutaminase activities (3-fold), with no changes in respiratory complexes I and IV activities. " 10/01/2005 - "Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumption." 10/01/2005 - "It was the aim of this study to evaluate the effect of hypoxia (20-30 microM) on the calcium-dependent activation of 2-oxoglutarate dehydrogenase (or 2-ketoglutarate dehydrogenase; OGDH) and mitochondrial nitric-oxide synthase (mtNOS). "
5.	Korsakoff Syndrome (Wernicke-Korsakoff Syndrome) 10/01/1993 - "Results of this study demonstrate significant reductions of TPP-dependent enzymes [pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase (alpha KGDH), and transketolase] in autopsied cerebellar vermis samples from alcoholic patients with the clinical and neuropathologically confirmed diagnosis of Wernicke-Korsakoff Syndrome (WKS). "

Related Drugs and Biologics

1.	Enzymes
2.	Oxidoreductases
3.	Succinate Dehydrogenase (Fumarate Reductase)
4.	Malate Dehydrogenase (Dehydrogenase, Malate)
5.	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)
6.	Transketolase
7.	NADP (NADPH)
8.	dihydrolipoamide succinyltransferase
9.	NAD (NADH)
10.	Calcium

Related Therapies and Procedures

1.	Ligation