Infectious Keratoconjunctivitis

Infectious diseases of cattle, sheep, and goats, characterized by blepharospasm, lacrimation, conjunctivitis, and varying degrees of corneal opacity and ulceration. In cattle the causative agent is MORAXELLA (MORAXELLA) BOVIS; in sheep, MYCOPLASMA; RICKETTSIA; CHLAMYDIA; or ACHOLEPLASMA; in goats, RICKETTSIA.

Also Known As:

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Herpetic Keratitis
2.	Infection

Experts

1.	Frey, Joachim: 2 articles (07/2010 - 01/2003)
2.	Frey, J: 2 articles (08/2003 - 03/2001)
3.	Maboni, Grazieli: 1 article (06/2015)
4.	Tasca, Caiane: 1 article (06/2015)
5.	de Vargas, Agueda Castagna: 1 article (06/2015)
6.	Gressler, Leticia T: 1 article (06/2015)
7.	Espindola, Julia P: 1 article (06/2015)
8.	Potter, Luciana: 1 article (06/2015)
9.	Schwab, Marcelo: 1 article (06/2015)
10.	Dallorso, Maria E: 1 article (06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infectious Keratoconjunctivitis:

1.	CopperIBA 06/01/2013 - "Our previous studies in copper-deficient bovines have shown increased susceptibility to infectious keratoconjunctivitis, an ocular disease caused by Moraxella bovis. " 06/01/2013 - "Other components of local and systemic ocular defense mechanisms that could explain the increased susceptibility to infectious keratoconjunctivitis observed in copper-deficient bovines should be investigated."
2.	florfenicolIBA 02/01/2013 - "To measure florfenicol concentrations in ovine tear fluid after IM and SC administration and determine minimum inhibitory concentrations (MICs) of florfenicol against field isolates of Mycoplasma organisms potentially involved in infectious keratoconjunctivitis. " 02/01/2013 - "Florfenicol concentrations in ovine tear fluid following intramuscular and subcutaneous administration and comparison with the minimum inhibitory concentrations against mycoplasmal strains potentially involved in infectious keratoconjunctivitis." 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "
3.	SilverIBA 04/01/2006 - "An infectious keratoconjunctivitis (IKC) epizootic in bighorn sheep (Ovis canadensis) occurred in the Silver Bell Mountains, Arizona, USA, from 1 December 2003 to 31 March 2004. " 04/01/2006 - "Infectious keratoconjunctivitis in bighorn sheep, Silver Bell Mountains, Arizona, USA."
4.	Serine (L-Serine)FDA Link 01/01/2003 - "A serine-rich membrane protein named LppS from Mycoplasma conjunctivae, the aetiological agent of infectious keratoconjunctivitis (IKC) of domestic and wild Caprinae, was characterized. "
5.	Penicillins (Penicillin)FDA Link 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "
6.	Oxytetracycline (Terramycin)FDA Link 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "
7.	NeomycinFDA LinkGeneric 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "
8.	Muramidase (Lysozyme)IBA 10/01/2000 - "Lysozyme concentrations in tears may vary among species and this variability may contribute to differing susceptibilities to ocular diseases such as infectious keratoconjunctivitis."
9.	Membrane Proteins (Integral Membrane Proteins)IBA 01/01/2003 - "A serine-rich membrane protein named LppS from Mycoplasma conjunctivae, the aetiological agent of infectious keratoconjunctivitis (IKC) of domestic and wild Caprinae, was characterized. "
10.	Lipoproteins (Lipoprotein)IBA 07/01/2010 - "Lipoprotein T (LppT), a membrane-located 105-kDa lipoprotein of Mycoplasma conjunctivae, the etiological agent of infectious keratoconjunctivitis (IKC) of domestic sheep and wild Caprinae, was characterized. "

Therapies and Procedures

1.	Immunomodulation 11/01/2006 - "Feline herpetic keratitis (infectious keratoconjunctivitis), an infection of the conjunctiva and cornea that is common in cats, involves a three-pronged treatment approach: (1)antiviral therapy, (2)immunomodulatory therapy, and (3)antibacterial therapy. "