Dendritic Keratitis

A form of herpetic keratitis characterized by the formation of small vesicles which break down and coalesce to form recurring dendritic ulcers, characteristically irregular, linear, branching, and ending in knoblike extremities. (Dictionary of Visual Science, 3d ed)

Also Known As:

Networked: 78 relevant articles (11 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Herpes Simplex
2.	Keratitis
3.	Herpetic Keratitis
4.	Acanthamoeba Keratitis
5.	Ulcer

Experts

1.	Inoue, Yoshitsugu: 2 articles (04/2013 - 01/2007)
2.	Hayashi, Kozaburo: 2 articles (02/2011 - 03/2004)
3.	Haruki, Tomoko: 1 article (04/2013)
4.	Yakura, Keiko: 1 article (04/2013)
5.	Yamamoto, Yukimi: 1 article (04/2013)
6.	Miyazaki, Dai: 1 article (04/2013)
7.	Suzuki, Hiroshi: 1 article (04/2013)
8.	Kandori, Michiko: 1 article (04/2013)
9.	Sasaki, Shin-ichi: 1 article (04/2013)
10.	Ursea, Roxana: 1 article (02/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dendritic Keratitis:

1.	Acyclovir (Aciclovir)FDA LinkGeneric 01/01/2007 - "A typical form of dendritic keratitis was caused by an acyclovir-resistant HSV with frameshift mutation in a 7Gs homopolymer region." 01/01/2007 - "A 70-year-old man with dendritic keratitis caused by an acyclovir-resistant HSV strain was examined. " 01/01/2007 - "Dendritic keratitis caused by an acyclovir-resistant herpes simplex virus with frameshift mutation." 04/01/1999 - "No patient in the acyclovir group had a recurrence of dendritic keratitis in the first year compared with 5 (21%) of the patients who did not receive acyclovir (P = .03). " 08/01/1996 - "We treated two patients with dendritic keratitis that did not respond to acyclovir (ACV) ointment therapy. "
2.	InterferonsIBA 07/17/1978 - "We conclude that interferon works basically as a prophylactic agent and needs the support of further antiviral measures to be effective against dendritic keratitis." 01/01/1987 - "Thus it seems possible to save about 90% of interferon commonly used in the combination therapy of dendritic keratitis by applying a mixture of different suitable interferons instead of interferon monospecies." 06/01/1985 - "Treatment of dendritic keratitis with a combination of a modern antiviral drug and high-titer interferon will reduce the average time the corneal epithelium takes to heal from the present 6 days to 3 days. " 06/01/1985 - "Significant progress in the treatment of dendritic keratitis is to be expected as soon as high-titer interferon preparations become commercially available. " 01/01/1977 - "[Human-interferon therapy in dendritic keratitis]."
3.	Trifluridine (Viroptic)FDA LinkGeneric 10/01/1985 - "Association of trifluorothymidine and débridement in herpetic dendritic keratitis." 10/01/1978 - "In a randomized double-blind study trifluorothymidine was tested for its ability to prevent dendritic keratitis at a dose of 5 drops daily in patients with steroid-treated herpetic keratouveitis. " 01/01/1985 - "23 patients with proven herpetic dendritic keratitis have been treated with combined blunt spatula debridement and trifluorothymidine. " 01/01/1985 - "Combined treatment of herpetic dendritic keratitis with blunt spatula debridement and trifluorothymidine." 05/01/1985 - "Our results suggest that débridement alone is suboptimal therapy for herpes simplex dendritic keratitis and that débridement combined with trifluridine appears to offer no advantage over trifluridine alone."
4.	Interferon-alpha (Interferon Alfa)FDA Link 11/18/1976 - "Successful treatment of dendritic keratitis with human leukocyte interferon. " 07/17/1978 - "In a controlled clinical study, 42 patients with dendritic keratitis were treated either with thermocautery plus human leukocyte interferon (HLI) or with minimal wiping debridement plus HLI. " 04/01/1984 - "Previous studies showed that the combination of trifluridine with human leukocyte interferon in the treatment of dendritic keratitis is effective, and that the best results were obtained with the highest titer then available (30 X 10(6) IU/mL). " 01/01/1987 - "High-titer gamma interferon did not significantly differ from high-titer alpha interferon in the combination therapy of dendritic keratitis. " 12/01/1983 - "Combination therapy for dendritic keratitis with acyclovir and alpha-interferon."
5.	Ophthalmic Solutions (Eye Drops)IBA 01/01/1983 - "In one patient recurrence of dendritic keratitis, 5 weeks after scraping, was treated by topical bromovinyldeoxyuridine eye drops. " 01/01/1987 - "Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. " 01/01/1984 - "In herpetic dendritic keratitis eye drops of fibroblast interferon may be useful as such or in combination with debridement. " 01/01/1987 - "The combination of high-titer human interferon eye drops with a basic therapy of topical antiviral agents has considerably improved therapeutic results in dendritic keratitis." 01/01/1991 - "Eighteen patients with typical Herpes simplex virus dendritic keratitis confirmed by viral isolation were treated with corneal collagen shields presoaked with trifluorothymidine for 15 minutes and trifluorothymidine eye drops 5 times daily. "
6.	Idoxuridine (Stoxil)FDA LinkGeneric 01/01/2000 - "For dendritic keratitis, idoxuridine was better than placebo at 7 days (combined odds ratio [OR], 3.59; 95% confidence interval [CI], 1.92-6.70), and at 14 days (OR, 4.17; 95% CI, 1.33-13.04), but pooling was limited by lack of homogeneity and low study quality. " 07/20/1982 - "In a double-blind study of acyclovir and idoxuridine in 60 patients with dendritic keratitis, acyclovir was shown to be superior and produced no serious side effects. " 12/01/1965 - "[Observations during the treatment of dendritic keratitis with 5-iodouracil 2-desoxyriboside (IUDR)]." 01/01/1990 - "Combined use of MDC and soft contact highly hydrophilic lenses preimpregnated with poludan, an interferon inductor solution, has helped reduce almost twofold the mean period of treatment of 80 patients with dendritic keratitis as compared to idoxuridine monotherapy. "
7.	Ganciclovir (Cytovene)FDA LinkGeneric 02/01/1996 - "Review of the relative efficacy of topical ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis showed that both treatment modalities were equally effective in their ability to heal the viral induced corneal ulceration. " 02/01/1996 - "This study was designed to assess the relative efficacy of topical ganciclovir 0.15% gel and acyclovir 3% ointment in the treatment of herpes simplex dendritic keratitis. " 02/01/1996 - "Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study."
8.	DNA (Deoxyribonucleic Acid)IBA 04/01/2013 - "Topical instillation of ASP2151 improved the herpetic dendritic keratitis score significantly and reduced the titre of HSV DNA in the tears in a dose-responsive way. " 02/01/2011 - ": In tear films collected from 3 of 9 patients with dendritic keratitis, HHV-6 DNA was positive twice, together with herpes simplex virus (HSV) or varicella zoster virus DNA most often, during the acute phase of the disease. "
9.	Antiviral Agents (Antivirals)IBA 08/01/1982 - "Fourty-three eyes with active dendritic keratitis, nearly one third of which had failed to respond to other antiviral agents, were treated with acyclovir with or without preceding debridement. " 01/01/1987 - "The combination of high-titer human interferon eye drops with a basic therapy of topical antiviral agents has considerably improved therapeutic results in dendritic keratitis."
10.	AntibodiesIBA 07/01/1986 - "To test the possibility of blockage of staining by the presumed development of circulating endogenous anti-HSV I antibodies, the corneas of eight consecutive patients who presented to the Albany Medical Center Hospital with known recurrent dendritic keratitis also were scraped and stained, using a similar procedure. " 01/01/1980 - "Herpes simplex antibodies in the form of pepsin-split gamma globulin are effective in cases of dendritic keratitis. "

Therapies and Procedures

1.	Lenses 01/01/1990 - "Combined use of MDC and soft contact highly hydrophilic lenses preimpregnated with poludan, an interferon inductor solution, has helped reduce almost twofold the mean period of treatment of 80 patients with dendritic keratitis as compared to idoxuridine monotherapy. "
2.	Debridement 07/17/1978 - "In a controlled clinical study, 42 patients with dendritic keratitis were treated either with thermocautery plus human leukocyte interferon (HLI) or with minimal wiping debridement plus HLI. " 01/01/1985 - "23 patients with proven herpetic dendritic keratitis have been treated with combined blunt spatula debridement and trifluorothymidine. " 01/01/1985 - "Combined treatment of herpetic dendritic keratitis with blunt spatula debridement and trifluorothymidine." 03/01/1981 - "We treated 25 patients with dendritic keratitis with debridement and 3% acyclovir ointment and another 25 with acyclovir alone. " 07/17/1978 - "Role of debridement and interferon in the treatment of dendritic keratitis."
3.	Cryotherapy (Therapy, Cold) 04/01/1988 - "[Studies of the mechanism of the effects of cryotherapy of experimental dendritic keratitis]." 05/03/1969 - "Cryotherapy for dendritic keratitis." 01/01/1968 - "Cryotherapy of dendritic keratitis." 01/01/1970 - "[Comparative studies on the effect of cryotherapy and iodization in combination with unspecific and virostatic after-treatment in dendritic keratitis]."
4.	Transplants (Transplant) 03/01/2004 - "The third patient developed dendritic keratitis in the graft. " 04/01/1999 - "Postoperative systemic acyclovir therapy after penetrating keratoplasty for HSV keratitis is associated with a reduced rate of recurrent HSV dendritic keratitis and possible graft failure at 1 year of follow-up."
5.	Corneal Transplantation (Keratoplasty) 09/15/1991 - "Herpes simplex dendritic keratitis after keratoplasty." 04/15/1991 - "We treated three patients with herpes simplex dendritic keratitis that occurred between three and 11 months after keratoplasty. " 04/15/1991 - "Herpes simplex dendritic keratitis after keratoplasty."